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Murcko scaffold

Spiro(cyclopropane-1,3'-indolin)-2'-one scaffold

169 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
12
Chemicals
169
With full pages
6
Scaffold SMILES

O=C1Nc2ccccc2C12CC2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Spiro(cyclopropane-1,3'-indolin)-2'-one page
Murcko scaffold O=C1Nc2ccccc2C12CC2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 169 chemicals

2'-Oxo-1',2'-dihydrospiro[cyclopropane-1,3'-indole]-2,2,3,3-tetracarbonitrile chemical structure, C14H5N5O, CAS 890092-31-6
2'-Oxo-1',2'-dihydrospiro[cyclopropane-1,3'-indole]-2,2,3,3-tetracarbonitrile
CAS 890092-31-6C14H5N5O
Ethyl 2'-oxospiro[cyclopropane-1,3'-indoline]-2-carboxylate chemical structure, C13H13NO3, CAS 67503-06-4
Ethyl 2'-oxospiro[cyclopropane-1,3'-indoline]-2-carboxylate
CAS 67503-06-4C13H13NO3
Racemic-(1R,2S)-ethyl 2-oxospiro[cyclopropane-1,3-indoline]-2-carboxylate chemical structure, C13H13NO3, CAS 1341038-75-2
Racemic-(1R,2S)-ethyl 2-oxospiro[cyclopropane-1,3-indoline]-2-carboxylate
CAS 1341038-75-2C13H13NO3
2'-Oxo-1',2'-dihydrospiro(cyclopropane-1,3'-indole)-3-carboxylic acid chemical structure, C11H9NO3, CAS 67503-08-6
2'-Oxo-1',2'-dihydrospiro(cyclopropane-1,3'-indole)-3-carboxylic acid
CAS 67503-08-6C11H9NO3
Spiro(cyclopropane-1,3'-indolin)-2'-one chemical structure, C10H9NO, CAS 13861-75-1
Spiro(cyclopropane-1,3'-indolin)-2'-one
CAS 13861-75-1C10H9NO
1'-Methylspiro[cyclopropane-1,3'-indolin]-2'-one chemical structure, C11H11NO, CAS 14276-11-0
1'-Methylspiro[cyclopropane-1,3'-indolin]-2'-one
CAS 14276-11-0C11H11NO
4'-Fluorospiro[cyclopropane-1,3'-indolin]-2'-one chemical structure, C10H8FNO, CAS 913720-11-3
4'-Fluorospiro[cyclopropane-1,3'-indolin]-2'-one
CAS 913720-11-3C10H8FNO
5'-Bromo-4'-fluorospiro[cyclopropane-1,3'-indolin]-2'-one chemical structure, C10H7BrFNO, CAS 913720-17-9
5'-Bromo-4'-fluorospiro[cyclopropane-1,3'-indolin]-2'-one
CAS 913720-17-9C10H7BrFNO
(1'R,3S)-2-Oxospiro[1H-indole-3,2'-cyclopropane]-1'-carbonitrile chemical structure, C11H8N2O, CAS 895576-37-1
(1'R,3S)-2-Oxospiro[1H-indole-3,2'-cyclopropane]-1'-carbonitrile
CAS 895576-37-1C11H8N2O
1'-(3-Chloropropyl)spiro[cyclopropane-1,3'-indolin]-2'-one chemical structure, C13H14ClNO, CAS 1352949-92-8
1'-(3-Chloropropyl)spiro[cyclopropane-1,3'-indolin]-2'-one
CAS 1352949-92-8C13H14ClNO
5'-Fluorospiro[cyclopropane-1,3'-indolin]-2'-one chemical structure, C10H8FNO, CAS 769965-95-9
5'-Fluorospiro[cyclopropane-1,3'-indolin]-2'-one
CAS 769965-95-9C10H8FNO
7'-Fluorospiro[cyclopropane-1,3'-indolin]-2'-one chemical structure, C10H8FNO, CAS 872141-30-5
7'-Fluorospiro[cyclopropane-1,3'-indolin]-2'-one
CAS 872141-30-5C10H8FNO
5'-Bromo-7'-fluorospiro[cyclopropane-1,3'-indolin]-2'-one chemical structure, C10H7BrFNO, CAS 872141-31-6
5'-Bromo-7'-fluorospiro[cyclopropane-1,3'-indolin]-2'-one
CAS 872141-31-6C10H7BrFNO
5'-Amino-1'-methylspiro[cyclopropane-1,3'-indolin]-2'-one chemical structure, C11H12N2O, CAS 1399657-25-0
5'-Amino-1'-methylspiro[cyclopropane-1,3'-indolin]-2'-one
CAS 1399657-25-0C11H12N2O
4'-(Aminomethyl)spiro[cyclopropane-1,3'-indolin]-2'-one chemical structure, C11H12N2O, CAS 1383682-18-5
4'-(Aminomethyl)spiro[cyclopropane-1,3'-indolin]-2'-one
CAS 1383682-18-5C11H12N2O
4'-Methoxyspiro[cyclopropane-1,3'-indolin]-2'-one chemical structure, C11H11NO2, CAS 424792-50-7
4'-Methoxyspiro[cyclopropane-1,3'-indolin]-2'-one
CAS 424792-50-7C11H11NO2
5'-Bromospiro[cyclopropane-1,3'-indolin]-2'-one chemical structure, C10H8BrNO, CAS 875071-97-9
5'-Bromospiro[cyclopropane-1,3'-indolin]-2'-one
CAS 875071-97-9C10H8BrNO
7-Bromo-4-fluorospiro[1H-indole-3,1'-cyclopropane]-2-one chemical structure, C10H7BrFNO, CAS 1360938-60-8
7-Bromo-4-fluorospiro[1H-indole-3,1'-cyclopropane]-2-one
CAS 1360938-60-8C10H7BrFNO
6'-Methylspiro[cyclopropane-1,3'-indolin]-2'-one chemical structure, C11H11NO, CAS 83419-47-0
6'-Methylspiro[cyclopropane-1,3'-indolin]-2'-one
CAS 83419-47-0C11H11NO
6'-(Trifluoromethyl)-spiro[cyclopropane-1,3'-[3H]indole]-2'(1'H)-one chemical structure, C11H8F3NO, CAS 83419-48-1
6'-(Trifluoromethyl)-spiro[cyclopropane-1,3'-[3H]indole]-2'(1'H)-one
CAS 83419-48-1C11H8F3NO
Spiro[cyclopropane-1,3'-[3H]indole]-2-carboxylic acid,1',2'-dihydro-2'-oxo-, (1R,2R)-rel- chemical structure, C11H9NO3, CAS 926667-78-9
Spiro[cyclopropane-1,3'-[3H]indole]-2-carboxylic acid,1',2'-dihydro-2'-oxo-, (1R,2R)-rel-
CAS 926667-78-9C11H9NO3
5'-Methoxyspiro[cyclopropane-1,3'-indolin]-2'-one chemical structure, C11H11NO2, CAS 1360946-96-8
5'-Methoxyspiro[cyclopropane-1,3'-indolin]-2'-one
CAS 1360946-96-8C11H11NO2
6'-Bromo-1',2'-dihydrospiro[cyclopropane-1,3'-indole]-2'-one chemical structure, C10H8BrNO, CAS 1378865-57-6
6'-Bromo-1',2'-dihydrospiro[cyclopropane-1,3'-indole]-2'-one
CAS 1378865-57-6C10H8BrNO
1'-Methyl-2'-oxospiro[cyclopropane-1,3'-indoline]-5'-carbonitrile chemical structure, C12H10N2O, CAS 1426228-10-5
1'-Methyl-2'-oxospiro[cyclopropane-1,3'-indoline]-5'-carbonitrile
CAS 1426228-10-5C12H10N2O