Murcko scaffold
Ring system with 3 rings and 23 atoms
58 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 23
- Chemicals
- 58
- With full pages
- 0
Scaffold SMILES
O=C(Nc1ccccc1)C1CCCN1S(=O)(=O)c1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 58 chemicals
(S)-N-(p-Tolyl)-1-tosylpyrrolidine-2-carboxamide
CAS 73096-28-3C19H22N2O3S
(2S)-1-(4-Chlorophenyl)sulfonyl-N-(2-methoxyphenyl)pyrrolidine-2-carboxamide
CAS 1212441-89-8C18H19ClN2O4S
(2S)-1-(4-Chlorophenyl)sulfonyl-N-phenylpyrrolidine-2-carboxamide
CAS 1212461-31-8C17H17ClN2O3S
(2S)-N-(2-Chlorophenyl)-1-(4-methylphenyl)sulfonylpyrrolidine-2-carboxamide
CAS 956158-65-9C18H19ClN2O3S
(2S)-1-(4-Chlorophenyl)sulfonyl-N-(4-methylphenyl)pyrrolidine-2-carboxamide
CAS 1212432-09-1C18H19ClN2O3S
(2S)-1-(4-Chlorophenyl)sulfonyl-N-(3-methylphenyl)pyrrolidine-2-carboxamide
CAS 1212485-82-9C18H19ClN2O3S
![1-[(4-Bromophenyl)sulfonyl]-N-(4-chlorophenyl)-2-pyrrolidinecarboxamide chemical structure, C17H16BrClN2O3S, CAS 317377-68-7](/s/VUWLAAFWMJSVRV-UHFFFAOYSA-N.svg)
1-[(4-Bromophenyl)sulfonyl]-N-(4-chlorophenyl)-2-pyrrolidinecarboxamide
CAS 317377-68-7C17H16BrClN2O3S
![1-[(4-Bromophenyl)sulfonyl]-N-[3-(trifluoromethyl)phenyl]-2-pyrrolidinecarboxamide chemical structure, C18H16BrF3N2O3S, CAS 317377-70-1](/s/POIPDYAUAAGQIR-UHFFFAOYSA-N.svg)
1-[(4-Bromophenyl)sulfonyl]-N-[3-(trifluoromethyl)phenyl]-2-pyrrolidinecarboxamide
CAS 317377-70-1C18H16BrF3N2O3S
![1-[(4-Bromophenyl)sulfonyl]-N-phenyl-2-pyrrolidinecarboxamide chemical structure, C17H17BrN2O3S, CAS 317377-72-3](/s/WNFPRCJAKLDWNJ-UHFFFAOYSA-N.svg)
1-[(4-Bromophenyl)sulfonyl]-N-phenyl-2-pyrrolidinecarboxamide
CAS 317377-72-3C17H17BrN2O3S
![1-[(4-Bromophenyl)sulfonyl]-N-(4-fluorophenyl)-2-pyrrolidinecarboxamide chemical structure, C17H16BrFN2O3S, CAS 317377-74-5](/s/XMPALYWLOAFUQG-UHFFFAOYSA-N.svg)
1-[(4-Bromophenyl)sulfonyl]-N-(4-fluorophenyl)-2-pyrrolidinecarboxamide
CAS 317377-74-5C17H16BrFN2O3S
1-(4-Bromobenzenesulfonyl)-N-(3,4-difluorophenyl)pyrrolidine-2-carboxamide
CAS 317377-76-7C17H15BrF2N2O3S
N-(4-Chlorophenyl)-1-(4-chlorophenyl)sulfonylpyrrolidine-2-carboxamide
CAS 317377-78-9C17H16Cl2N2O3S
1-(4-Chlorophenyl)sulfonyl-N-phenylpyrrolidine-2-carboxamide
CAS 317377-80-3C17H17ClN2O3S
![1-(4-Chlorophenyl)sulfonyl-N-[3-(trifluoromethyl)phenyl]pyrrolidine-2-carboxamide chemical structure, C18H16ClF3N2O3S, CAS 317377-82-5](/s/YVTSYSRRPZKUPN-UHFFFAOYSA-N.svg)
1-(4-Chlorophenyl)sulfonyl-N-[3-(trifluoromethyl)phenyl]pyrrolidine-2-carboxamide
CAS 317377-82-5C18H16ClF3N2O3S
![1-(4-Fluorobenzenesulfonyl)-N-[4-(trifluoromethoxy)phenyl]pyrrolidine-2-carboxamide chemical structure, C18H16F4N2O4S, CAS 317377-84-7](/s/FDFUDPAWFUAXDH-UHFFFAOYSA-N.svg)
1-(4-Fluorobenzenesulfonyl)-N-[4-(trifluoromethoxy)phenyl]pyrrolidine-2-carboxamide
CAS 317377-84-7C18H16F4N2O4S
![1-(4-Fluorophenyl)sulfonyl-N-[3-(trifluoromethyl)phenyl]pyrrolidine-2-carboxamide chemical structure, C18H16F4N2O3S, CAS 317377-86-9](/s/DXDQVRALCNHCIV-UHFFFAOYSA-N.svg)
1-(4-Fluorophenyl)sulfonyl-N-[3-(trifluoromethyl)phenyl]pyrrolidine-2-carboxamide
CAS 317377-86-9C18H16F4N2O3S
![N-(3,4-Difluorophenyl)-1-[(4-fluorophenyl)sulfonyl]-2-pyrrolidinecarboxamide chemical structure, C17H15F3N2O3S, CAS 317377-88-1](/s/LLOJNLQUVQDNHC-UHFFFAOYSA-N.svg)
N-(3,4-Difluorophenyl)-1-[(4-fluorophenyl)sulfonyl]-2-pyrrolidinecarboxamide
CAS 317377-88-1C17H15F3N2O3S
![N-(4-Chlorophenyl)-1-[(4-fluorophenyl)sulfonyl]-2-pyrrolidinecarboxamide chemical structure, C17H16ClFN2O3S, CAS 317377-90-5](/s/AEPZYGAXVVIMGB-UHFFFAOYSA-N.svg)
N-(4-Chlorophenyl)-1-[(4-fluorophenyl)sulfonyl]-2-pyrrolidinecarboxamide
CAS 317377-90-5C17H16ClFN2O3S
![1-[(2-Chlorophenyl)sulfonyl]-N-[3-(trifluoromethyl)phenyl]-2-pyrrolidinecarboxamide chemical structure, C18H16ClF3N2O3S, CAS 317377-92-7](/s/HHKCJTFEUQXATN-UHFFFAOYSA-N.svg)
1-[(2-Chlorophenyl)sulfonyl]-N-[3-(trifluoromethyl)phenyl]-2-pyrrolidinecarboxamide
CAS 317377-92-7C18H16ClF3N2O3S
![1-[(4-Bromophenyl)sulfonyl]-N-(3-chlorophenyl)-2-pyrrolidinecarboxamide chemical structure, C17H16BrClN2O3S, CAS 1007931-99-8](/s/CINZBXUZNSLZQR-UHFFFAOYSA-N.svg)
1-[(4-Bromophenyl)sulfonyl]-N-(3-chlorophenyl)-2-pyrrolidinecarboxamide
CAS 1007931-99-8C17H16BrClN2O3S
1-(4-Methylphenyl)sulfonyl-N-(4-nitrophenyl)pyrrolidine-2-carboxamide
CAS 1188362-76-6C18H19N3O5S
1-(4-Chlorophenyl)sulfonyl-N-(3,5-dimethylphenyl)pyrrolidine-2-carboxamide
CAS 473708-85-9C19H21ClN2O3S
N-(4-Methoxyphenyl)-1-tosylpyrrolidine-2-carboxamide
CAS 1095953-42-6C19H22N2O4S
![Methyl 4-({1-[(4-methoxyphenyl)sulfonyl]prolyl}amino)benzoate chemical structure, C20H22N2O6S, CAS 1008039-66-4](/s/UHDPCTXQXPNTOC-UHFFFAOYSA-N.svg)
Methyl 4-({1-[(4-methoxyphenyl)sulfonyl]prolyl}amino)benzoate
CAS 1008039-66-4C20H22N2O6S
- N-(4-Hydroxyphenyl)-1-(4-methylphenyl)sulfonylpyrrolidine-2-carboxamide1008186-34-2C18H20N2O4S
- 1-[(4-Fluorophenyl)sulfonyl]-N-(4-hydroxyphenyl)prolinamide1008935-72-5C17H17FN2O4S
- N-(4-Hydroxyphenyl)-1-[(4-methoxyphenyl)sulfonyl]prolinamide1008935-73-6C18H20N2O5S
- 1-(4-Chlorophenyl)sulfonyl-N-(2-propan-2-ylphenyl)pyrrolidine-2-carboxamide473708-69-9C20H23ClN2O3S
- N-(4-Chlorophenyl)-1-{[3-(trifluoromethyl)phenyl]sulfonyl}-2-pyrrolidinecarboxamide317822-03-0C18H16ClF3N2O3S
- N-(2,6-Diethylphenyl)-1-{[3-(trifluoromethyl)phenyl]sulfonyl}-2-pyrrolidinecarboxamide317822-04-1C22H25F3N2O3S
- N-[4-(Trifluoromethoxy)phenyl]-1-{[3-(trifluoromethyl)phenyl]sulfonyl}-2-pyrrolidinecarboxamide317822-00-7C19H16F6N2O4S
- Methyl 4-(1-tosylpyrrolidine-2-carboxamido)benzoate1008012-65-4C20H22N2O5S
- N-(3,5-Dichlorophenyl)-1-{[3-(trifluoromethyl)phenyl]sulfonyl}-2-pyrrolidinecarboxamide317822-01-8C18H15Cl2F3N2O3S
- N-(5-Chloro-2-methoxyphenyl)-1-(4-chlorophenyl)sulfonylpyrrolidine-2-carboxamide473709-28-3C18H18Cl2N2O4S
- N-[4-(Acetylamino)phenyl]-1-{[3-(trifluoromethyl)phenyl]sulfonyl}-2-pyrrolidinecarboxamide317822-02-9C20H20F3N3O4S
- Methyl 3-[[1-(4-chlorophenyl)sulfonylpyrrolidine-2-carbonyl]amino]benzoate6998-40-9C19H19ClN2O5S
- 1-Tosyl-N-(3-(trifluoromethyl)phenyl)pyrrolidine-2-carboxamide1008995-15-0C19H19F3N2O3S
- N-(2,4-Dichlorophenyl)-1-[(4-methylphenyl)sulfonyl]prolinamide1025714-82-2C18H18Cl2N2O3S
- N-(3,4-Dichlorophenyl)-1-[(4-fluorophenyl)sulfonyl]prolinamide1047981-25-8C17H15Cl2FN2O3S
- N-(2,5-Dichlorophenyl)-1-[(4-methoxyphenyl)sulfonyl]prolinamide1025720-45-9C18H18Cl2N2O4S
- N-(4-Chlorophenyl)-1-[(4-ethoxyphenyl)sulfonyl]prolinamide1033850-79-1C19H21ClN2O4S
- N-(2,4-Dichlorophenyl)-1-[(4-methoxyphenyl)sulfonyl]prolinamide1046759-58-3C18H18Cl2N2O4S
- N-(2-Carbamoylphenyl)-1-[(4-chlorophenyl)sulfonyl]prolinamide1007922-44-2C18H18ClN3O4S
- N-(3,4-Dichlorophenyl)-1-[(4-methoxyphenyl)sulfonyl]prolinamide1043429-96-4C18H18Cl2N2O4S
- N-(2,5-Dichlorophenyl)-1-[(4-methylphenyl)sulfonyl]-2-pyrrolidinecarboxamide1025392-96-4C18H18Cl2N2O3S
- N-(2,5-Dichlorophenyl)-1-[(4-fluorophenyl)sulfonyl]prolinamide1025393-00-3C17H15Cl2FN2O3S
- 1-[(4-Methoxyphenyl)sulfonyl]-N-[3-(trifluoromethyl)phenyl]prolinamide1025393-07-0C19H19F3N2O4S
- Methyl 4-({1-[(4-ethoxyphenyl)sulfonyl]prolyl}amino)benzoate1025393-10-5C21H24N2O6S
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold S=c1[nH]nc(CCc2ccccc2)n1Cc1ccccc1](/scaffold/LFXOIUDSACXIBV-UHFFFAOYSA-N/structure.svg)
![Scaffold O=C(c1ccccc1)c1cn[nH]c1OS(=O)(=O)c1ccccc1](/scaffold/QRASLEZQDVFMKO-UHFFFAOYSA-N/structure.svg)
