Murcko scaffold
Ring system with 4 rings and 19 atoms
17 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 19
- Chemicals
- 17
- With full pages
- 3
Scaffold SMILES
c1ccn(-c2ccsc2-c2cc3ncccn3n2)c1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 17 of 17 chemicals
![5,7-Dimethyl-2-[3-(1H-pyrrol-1-yl)-2-thienyl]pyrazolo[1,5-a]pyrimidine chemical structure, C16H14N4S, CAS 477888-82-7](/s/FLNVTPWQXXHJIQ-UHFFFAOYSA-N.svg)
5,7-Dimethyl-2-[3-(1H-pyrrol-1-yl)-2-thienyl]pyrazolo[1,5-a]pyrimidine
CAS 477888-82-7C16H14N4S
![2-[3-(2,5-Dimethyl-1H-pyrrol-1-yl)-2-thienyl]-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C17H17N5O2S2, CAS 439109-03-2](/s/JSNAMJLXLSSSGE-UHFFFAOYSA-N.svg)
2-[3-(2,5-Dimethyl-1H-pyrrol-1-yl)-2-thienyl]-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS 439109-03-2C17H17N5O2S2
![2-[3-(2,5-Dimethyl-1H-pyrrol-1-yl)-2-thienyl]-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidine chemical structure, C18H12F6N4S, CAS 692287-82-4](/s/GECIRPATOTUJFO-UHFFFAOYSA-N.svg)
2-[3-(2,5-Dimethyl-1H-pyrrol-1-yl)-2-thienyl]-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 692287-82-4C18H12F6N4S
![6-Chloro-2-[3-(2,5-dimethyl-1H-pyrrol-1-yl)-2-thienyl]-5,7-dimethylpyrazolo[1,5-a]pyrimidine chemical structure, C18H17ClN4S, CAS 439110-96-0](/s/OFMHNVHUVSFZHM-UHFFFAOYSA-N.svg)
6-Chloro-2-[3-(2,5-dimethyl-1H-pyrrol-1-yl)-2-thienyl]-5,7-dimethylpyrazolo[1,5-a]pyrimidine
CAS 439110-96-0C18H17ClN4S
![2-[3-(2,5-Dimethyl-1H-pyrrol-1-yl)-2-thienyl]-5,7-dimethyl-6-propylpyrazolo[1,5-a]pyrimidine chemical structure, C21H24N4S, CAS 692287-85-7](/s/RFVJDZCWFATVAI-UHFFFAOYSA-N.svg)
2-[3-(2,5-Dimethyl-1H-pyrrol-1-yl)-2-thienyl]-5,7-dimethyl-6-propylpyrazolo[1,5-a]pyrimidine
CAS 692287-85-7C21H24N4S
![2-[3-(2,5-Dimethyl-1H-pyrrol-1-yl)-2-thienyl]-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carbonitrile chemical structure, C18H12F3N5S, CAS 478078-03-4](/s/ZAANIQOAHYGIIK-UHFFFAOYSA-N.svg)
2-[3-(2,5-Dimethyl-1H-pyrrol-1-yl)-2-thienyl]-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carbonitrile
CAS 478078-03-4C18H12F3N5S
![2-[3-(2,5-Dimethyl-1H-pyrrol-1-yl)-2-thienyl]-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine chemical structure, C17H13F3N4S, CAS 692738-09-3](/s/IFOXNKOWLQWEQK-UHFFFAOYSA-N.svg)
2-[3-(2,5-Dimethyl-1H-pyrrol-1-yl)-2-thienyl]-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 692738-09-3C17H13F3N4S
![Methyl 7-amino-2-[3-(2,5-dimethyl-1H-pyrrol-1-yl)-2-thienyl]pyrazolo[1,5-a]pyrimidine-6-carboxylate chemical structure, C18H17N5O2S, CAS 691872-98-7](/s/GRJZTCOXIMEYKC-UHFFFAOYSA-N.svg)
Methyl 7-amino-2-[3-(2,5-dimethyl-1H-pyrrol-1-yl)-2-thienyl]pyrazolo[1,5-a]pyrimidine-6-carboxylate
CAS 691872-98-7C18H17N5O2S
![7-Amino-2-[3-(2,5-dimethyl-1H-pyrrol-1-yl)-2-thienyl]pyrazolo[1,5-a]pyrimidine-6-carboxylic acid chemical structure, C17H15N5O2S, CAS 691873-06-0](/s/DFNIBTYTEKPVFC-UHFFFAOYSA-N.svg)
7-Amino-2-[3-(2,5-dimethyl-1H-pyrrol-1-yl)-2-thienyl]pyrazolo[1,5-a]pyrimidine-6-carboxylic acid
CAS 691873-06-0C17H15N5O2S
![5-Methyl-2-[3-(1H-pyrrol-1-yl)-2-thienyl]-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine chemical structure, C16H11F3N4S, CAS 439109-43-0](/s/WIUITDRRMMWTAN-UHFFFAOYSA-N.svg)
5-Methyl-2-[3-(1H-pyrrol-1-yl)-2-thienyl]-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 439109-43-0C16H11F3N4S
![2-[3-(2,5-Dimethyl-1H-pyrrol-1-yl)-2-thienyl]-3,5,7-trimethylpyrazolo[1,5-a]pyrimidine chemical structure, C19H20N4S, CAS 677749-57-4](/s/AMJWEPGZVVNYKS-UHFFFAOYSA-N.svg)
2-[3-(2,5-Dimethyl-1H-pyrrol-1-yl)-2-thienyl]-3,5,7-trimethylpyrazolo[1,5-a]pyrimidine
CAS 677749-57-4C19H20N4S
![2-[3-(2,5-Dimethyl-1H-pyrrol-1-yl)-2-thienyl]-5-methylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C17H17N5S, CAS 691869-93-9](/s/ZHXDGOXGFVJGJA-UHFFFAOYSA-N.svg)
2-[3-(2,5-Dimethyl-1H-pyrrol-1-yl)-2-thienyl]-5-methylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 691869-93-9C17H17N5S
![5,6,7-Trimethyl-2-[3-(1H-pyrrol-1-yl)-2-thienyl]pyrazolo[1,5-a]pyrimidine chemical structure, C17H16N4S, CAS 478039-43-9](/s/XNVVFUCGFZVYPO-UHFFFAOYSA-N.svg)
5,6,7-Trimethyl-2-[3-(1H-pyrrol-1-yl)-2-thienyl]pyrazolo[1,5-a]pyrimidine
CAS 478039-43-9C17H16N4S
![7-[Chloro(difluoro)methyl]-2-[3-(2,5-dimethyl-1H-pyrrol-1-yl)-2-thienyl]-5-methylpyrazolo[1,5-a]pyrimidine chemical structure, C18H15ClF2N4S, CAS 672949-51-8](/s/ZPRBUXHKYXXNPF-UHFFFAOYSA-N.svg)
7-[Chloro(difluoro)methyl]-2-[3-(2,5-dimethyl-1H-pyrrol-1-yl)-2-thienyl]-5-methylpyrazolo[1,5-a]pyrimidine
CAS 672949-51-8C18H15ClF2N4S
![2-[3-(1H-Pyrrol-1-yl)-2-thienyl]-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidine chemical structure, C16H8F6N4S, CAS 439109-45-2](/s/MXALSQFALDXYNM-UHFFFAOYSA-N.svg)
2-[3-(1H-Pyrrol-1-yl)-2-thienyl]-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 439109-45-2C16H8F6N4S
![2-[3-(2,5-Dimethyl-1H-pyrrol-1-yl)-2-thienyl]-5,7-dimethylpyrazolo[1,5-a]pyrimidine chemical structure, C18H18N4S, CAS 672949-41-6](/s/AJYZMDVFIADAED-UHFFFAOYSA-N.svg)
2-[3-(2,5-Dimethyl-1H-pyrrol-1-yl)-2-thienyl]-5,7-dimethylpyrazolo[1,5-a]pyrimidine
CAS 672949-41-6C18H18N4S
![6-(tert-Butylsulfonyl)-2-[3-(2,5-dimethyl-1H-pyrrol-1-yl)-2-thienyl]pyrazolo[1,5-A]pyrimidin-7-amine chemical structure, C20H23N5O2S2, CAS 861212-81-9](/s/VWVSCBMKRKCHKX-UHFFFAOYSA-N.svg)
6-(tert-Butylsulfonyl)-2-[3-(2,5-dimethyl-1H-pyrrol-1-yl)-2-thienyl]pyrazolo[1,5-A]pyrimidin-7-amine
CAS 861212-81-9C20H23N5O2S2
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=c1ccnc2cc(-c3ccsc3-n3cccc3)[nH]n12](/scaffold/PCJHEQUXHFNJTH-UHFFFAOYSA-N/structure.svg)
![Scaffold O=c1ccnc2cc(-c3sccc3-n3cccc3)[nH]n12](/scaffold/OTMTYFQUHSZBPK-UHFFFAOYSA-N/structure.svg)