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Murcko scaffold

Ring system with 2 rings and 17 atoms

39 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
17
Chemicals
39
With full pages
6
Scaffold SMILES

O=C(Nc1c[nH]c(=O)[nH]c1=O)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1c[nH]c(=O)[nH]c1=O)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 39 of 39 chemicals

Acetanilide, 4'-(N-(6-amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)carbamoyl)- chemical structure, C15H17N5O4, CAS 73623-32-2
Acetanilide, 4'-(N-(6-amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)carbamoyl)-
CAS 73623-32-2C15H17N5O4
2-Amino-N-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)benzamide chemical structure, C12H12N4O3, CAS 56742-10-0
2-Amino-N-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)benzamide
CAS 56742-10-0C12H12N4O3
N-(2,4-Dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-fluorobenzamide chemical structure, C11H8FN3O3, CAS 424799-26-8
N-(2,4-Dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-fluorobenzamide
CAS 424799-26-8C11H8FN3O3
RefChem:381332 chemical structure, C11H8FN3O3, CAS 333343-48-9
RefChem:381332
CAS 333343-48-9C11H8FN3O3
RefChem:382191 chemical structure, C12H11N3O3, CAS 665025-71-8
RefChem:382191
CAS 665025-71-8C12H11N3O3
N-(2,4-Dihydroxy-6-methylpyrimidin-5-yl)benzamide chemical structure, C12H11N3O3, CAS 591726-19-1
N-(2,4-Dihydroxy-6-methylpyrimidin-5-yl)benzamide
CAS 591726-19-1C12H11N3O3
2-Methyl-N-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)benzamide chemical structure, C13H13N3O3, CAS 662155-86-4
2-Methyl-N-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)benzamide
CAS 662155-86-4C13H13N3O3
N-(2,4-Dioxo-1H-pyrimidin-5-yl)-3,4-dimethylbenzamide chemical structure, C13H13N3O3, CAS 831207-32-0
N-(2,4-Dioxo-1H-pyrimidin-5-yl)-3,4-dimethylbenzamide
CAS 831207-32-0C13H13N3O3
N-(6-Methyl-2,4-dioxo-1H-pyrimidin-5-yl)-2-nitrobenzamide chemical structure, C12H10N4O5, CAS 56742-05-3
N-(6-Methyl-2,4-dioxo-1H-pyrimidin-5-yl)-2-nitrobenzamide
CAS 56742-05-3C12H10N4O5
N-(6-Amino-1-butyl-2,4-dioxopyrimidin-5-yl)-N-ethyl-2-methylbenzamide chemical structure, C18H24N4O3, CAS 853354-61-7
N-(6-Amino-1-butyl-2,4-dioxopyrimidin-5-yl)-N-ethyl-2-methylbenzamide
CAS 853354-61-7C18H24N4O3
N-(6-Amino-1-butyl-2,4-dioxopyrimidin-5-yl)-N-ethyl-3-fluorobenzamide chemical structure, C17H21FN4O3, CAS 853354-97-9
N-(6-Amino-1-butyl-2,4-dioxopyrimidin-5-yl)-N-ethyl-3-fluorobenzamide
CAS 853354-97-9C17H21FN4O3
N-(4-Amino-1,3-dimethyl-2,6-dioxopyrimidin-5-yl)-4-methoxybenzamide chemical structure, C14H16N4O4, CAS 166115-69-1
N-(4-Amino-1,3-dimethyl-2,6-dioxopyrimidin-5-yl)-4-methoxybenzamide
CAS 166115-69-1C14H16N4O4
N-(4-Amino-1,3-dimethyl-2,6-dioxopyrimidin-5-yl)-3,4,5-trimethoxybenzamide chemical structure, C16H20N4O6, CAS 166115-72-6
N-(4-Amino-1,3-dimethyl-2,6-dioxopyrimidin-5-yl)-3,4,5-trimethoxybenzamide
CAS 166115-72-6C16H20N4O6
N-(4-Amino-1,3-dimethyl-2,6-dioxopyrimidin-5-yl)-3-methoxybenzamide chemical structure, C14H16N4O4, CAS 166115-68-0
N-(4-Amino-1,3-dimethyl-2,6-dioxopyrimidin-5-yl)-3-methoxybenzamide
CAS 166115-68-0C14H16N4O4
N-(4-Amino-1,3-dimethyl-2,6-dioxopyrimidin-5-yl)-4-chlorobenzamide chemical structure, C13H13ClN4O3, CAS 166115-74-8
N-(4-Amino-1,3-dimethyl-2,6-dioxopyrimidin-5-yl)-4-chlorobenzamide
CAS 166115-74-8C13H13ClN4O3
N-(4-Amino-1,3-dimethyl-2,6-dioxopyrimidin-5-yl)-4-(diethoxyphosphorylmethyl)benzamide chemical structure, C18H25N4O6P, CAS 166115-75-9
N-(4-Amino-1,3-dimethyl-2,6-dioxopyrimidin-5-yl)-4-(diethoxyphosphorylmethyl)benzamide
CAS 166115-75-9C18H25N4O6P
N-(6-Amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3,4-dimethoxybenzamide chemical structure, C15H18N4O5, CAS 166115-70-4
N-(6-Amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3,4-dimethoxybenzamide
CAS 166115-70-4C15H18N4O5
N-(4-Amino-1,3-dimethyl-2,6-dioxopyrimidin-5-yl)-2-methoxybenzamide chemical structure, C14H16N4O4, CAS 166115-65-7
N-(4-Amino-1,3-dimethyl-2,6-dioxopyrimidin-5-yl)-2-methoxybenzamide
CAS 166115-65-7C14H16N4O4
N-(4-Amino-1,3-dimethyl-2,6-dioxopyrimidin-5-yl)-2-chlorobenzamide chemical structure, C13H13ClN4O3, CAS 166115-73-7
N-(4-Amino-1,3-dimethyl-2,6-dioxopyrimidin-5-yl)-2-chlorobenzamide
CAS 166115-73-7C13H13ClN4O3
N-(6-Amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3,5-di-tert-butyl-4-hydroxybenzamide chemical structure, C21H30N4O4, CAS 595558-79-5
N-(6-Amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3,5-di-tert-butyl-4-hydroxybenzamide
CAS 595558-79-5C21H30N4O4
2-Amino-N-(6-amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydropyrimidin-5-yl)-4-chlorobenzamide chemical structure, C17H22ClN5O3, CAS 93214-81-4
2-Amino-N-(6-amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydropyrimidin-5-yl)-4-chlorobenzamide
CAS 93214-81-4C17H22ClN5O3
2-Amino-N-(6-amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)benzamide chemical structure, C13H15N5O3, CAS 18830-59-6
2-Amino-N-(6-amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)benzamide
CAS 18830-59-6C13H15N5O3
N-(6-Amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydropyrimidin-5-yl)-3,5-dichloro-2-(2,2,2-trifluoroacetamido)benzamide chemical structure, C19H20Cl2F3N5O4, CAS 154623-75-3
N-(6-Amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydropyrimidin-5-yl)-3,5-dichloro-2-(2,2,2-trifluoroacetamido)benzamide
CAS 154623-75-3C19H20Cl2F3N5O4
4-Amino-N-(6-amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)benzamide chemical structure, C13H15N5O3, CAS 856571-99-8
4-Amino-N-(6-amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)benzamide
CAS 856571-99-8C13H15N5O3