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Murcko scaffold

Ring system with 4 rings and 25 atoms

7 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
7
With full pages
2
Scaffold SMILES

O=C(Nc1cc2c(s1)CCCC2)c1ccc(N2C(=O)CCC2=O)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1cc2c(s1)CCCC2)c1ccc(N2C(=O)CCC2=O)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 7 of 7 chemicals

2-[4-(2,5-Dioxopyrrolidin-1-yl)benzamido]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C20H19N3O4S, CAS 329906-56-1
2-[4-(2,5-Dioxopyrrolidin-1-yl)benzamido]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 329906-56-1C20H19N3O4S
Ethyl 2-(4-(2,5-dioxopyrrolidin-1-yl)benzamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate chemical structure, C22H22N2O5S, CAS 313405-98-0
Ethyl 2-(4-(2,5-dioxopyrrolidin-1-yl)benzamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate
CAS 313405-98-0C22H22N2O5S
Ethyl 2-({[4-(2,5-dioxopyrrolidin-1-yl)phenyl]carbonyl}amino)-6-(2-methylbutan-2-yl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C27H32N2O5S, CAS 461051-38-7
Ethyl 2-({[4-(2,5-dioxopyrrolidin-1-yl)phenyl]carbonyl}amino)-6-(2-methylbutan-2-yl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 461051-38-7C27H32N2O5S
2-(4-(2,5-Dioxopyrrolidin-1-yl)benzamido)-5-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide chemical structure, C21H21N3O4S, CAS 329903-37-9
2-(4-(2,5-Dioxopyrrolidin-1-yl)benzamido)-5-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide
CAS 329903-37-9C21H21N3O4S
N-(3-Cyano-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-4-(2,5-dioxopyrrolidin-1-yl)benzamide chemical structure, C21H19N3O3S, CAS 330201-01-9
N-(3-Cyano-5-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-4-(2,5-dioxopyrrolidin-1-yl)benzamide
CAS 330201-01-9C21H19N3O3S
Ethyl 2-(4-(2,5-dioxopyrrolidin-1-yl)benzamido)-6-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate chemical structure, C23H24N2O5S, CAS 681236-05-5
Ethyl 2-(4-(2,5-dioxopyrrolidin-1-yl)benzamido)-6-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate
CAS 681236-05-5C23H24N2O5S
2-[4-(2,5-Dioxopyrrolidin-1-yl)benzamido]-N,6-dimethyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C22H23N3O4S, CAS 892978-51-7
2-[4-(2,5-Dioxopyrrolidin-1-yl)benzamido]-N,6-dimethyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 892978-51-7C22H23N3O4S