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Murcko scaffold

Ring system with 4 rings and 25 atoms

60 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
60
With full pages
6
Scaffold SMILES

O=C(N=c1[nH]c2ccccc2s1)c1ccc(N2C(=O)CCC2=O)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(N=c1[nH]c2ccccc2s1)c1ccc(N2C(=O)CCC2=O)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 60 chemicals

(E)-4-(2,5-Dioxopyrrolidin-1-yl)-N-(3-methylbenzo[d]thiazol-2(3H)-ylidene)benzamide chemical structure, C19H15N3O3S, CAS 307327-07-7
(E)-4-(2,5-Dioxopyrrolidin-1-yl)-N-(3-methylbenzo[d]thiazol-2(3H)-ylidene)benzamide
CAS 307327-07-7C19H15N3O3S
N-(4-Chloro-1,3-benzothiazol-2-yl)-4-(2,5-dioxopyrrolidin-1-yl)benzamide chemical structure, C18H12ClN3O3S, CAS 313405-84-4
N-(4-Chloro-1,3-benzothiazol-2-yl)-4-(2,5-dioxopyrrolidin-1-yl)benzamide
CAS 313405-84-4C18H12ClN3O3S
4-(2,5-Dioxopyrrolidin-1-yl)-N-(3-ethyl-6-fluoro-1,3-benzothiazol-2-ylidene)benzamide chemical structure, C20H16FN3O3S, CAS 865544-97-4
4-(2,5-Dioxopyrrolidin-1-yl)-N-(3-ethyl-6-fluoro-1,3-benzothiazol-2-ylidene)benzamide
CAS 865544-97-4C20H16FN3O3S
N-[6-(Diethylsulfamoyl)-1,3-benzothiazol-2-yl]-4-(2,5-dioxopyrrolidin-1-yl)benzamide chemical structure, C22H22N4O5S2, CAS 865592-59-2
N-[6-(Diethylsulfamoyl)-1,3-benzothiazol-2-yl]-4-(2,5-dioxopyrrolidin-1-yl)benzamide
CAS 865592-59-2C22H22N4O5S2
(Z)-4-(2,5-Dioxopyrrolidin-1-yl)-N-(3-ethyl-4,7-dimethoxybenzo[d]thiazol-2(3H)-ylidene)benzamide chemical structure, C22H21N3O5S, CAS 1164536-00-8
(Z)-4-(2,5-Dioxopyrrolidin-1-yl)-N-(3-ethyl-4,7-dimethoxybenzo[d]thiazol-2(3H)-ylidene)benzamide
CAS 1164536-00-8C22H21N3O5S
(Z)-4-(2,5-Dioxopyrrolidin-1-yl)-N-(3-ethyl-4,6-difluorobenzo[d]thiazol-2(3H)-ylidene)benzamide chemical structure, C20H15F2N3O3S, CAS 868375-06-8
(Z)-4-(2,5-Dioxopyrrolidin-1-yl)-N-(3-ethyl-4,6-difluorobenzo[d]thiazol-2(3H)-ylidene)benzamide
CAS 868375-06-8C20H15F2N3O3S
(Z)-4-(2,5-Dioxopyrrolidin-1-yl)-N-(4-fluoro-3-methylbenzo[d]thiazol-2(3H)-ylidene)benzamide chemical structure, C19H14FN3O3S, CAS 868375-07-9
(Z)-4-(2,5-Dioxopyrrolidin-1-yl)-N-(4-fluoro-3-methylbenzo[d]thiazol-2(3H)-ylidene)benzamide
CAS 868375-07-9C19H14FN3O3S
(Z)-N-(3-Allyl-4-methoxybenzo[d]thiazol-2(3H)-ylidene)-4-(2,5-dioxopyrrolidin-1-yl)benzamide chemical structure, C22H19N3O4S, CAS 1322201-81-9
(Z)-N-(3-Allyl-4-methoxybenzo[d]thiazol-2(3H)-ylidene)-4-(2,5-dioxopyrrolidin-1-yl)benzamide
CAS 1322201-81-9C22H19N3O4S
(Z)-N-(3-Allyl-4-ethoxybenzo[d]thiazol-2(3H)-ylidene)-4-(2,5-dioxopyrrolidin-1-yl)benzamide chemical structure, C23H21N3O4S, CAS 1321969-67-8
(Z)-N-(3-Allyl-4-ethoxybenzo[d]thiazol-2(3H)-ylidene)-4-(2,5-dioxopyrrolidin-1-yl)benzamide
CAS 1321969-67-8C23H21N3O4S
N-(5,7-Dimethyl-3-prop-2-ynyl-1,3-benzothiazol-2-ylidene)-4-(2,5-dioxopyrrolidin-1-yl)benzamide chemical structure, C23H19N3O3S, CAS 868377-94-0
N-(5,7-Dimethyl-3-prop-2-ynyl-1,3-benzothiazol-2-ylidene)-4-(2,5-dioxopyrrolidin-1-yl)benzamide
CAS 868377-94-0C23H19N3O3S
4-(2,5-Dioxopyrrolidin-1-yl)-N-(4-methoxy-6-nitro-1,3-benzothiazol-2-yl)benzamide chemical structure, C19H14N4O6S, CAS 328027-82-3
4-(2,5-Dioxopyrrolidin-1-yl)-N-(4-methoxy-6-nitro-1,3-benzothiazol-2-yl)benzamide
CAS 328027-82-3C19H14N4O6S
4-(2,5-Dioxopyrrolidin-1-yl)-N-(6-methylsulfonyl-1,3-benzothiazol-2-yl)benzamide chemical structure, C19H15N3O5S2, CAS 329905-27-3
4-(2,5-Dioxopyrrolidin-1-yl)-N-(6-methylsulfonyl-1,3-benzothiazol-2-yl)benzamide
CAS 329905-27-3C19H15N3O5S2
4-(2,5-Dioxopyrrolidin-1-yl)-N-(4-methoxy-1,3-benzothiazol-2-yl)benzamide chemical structure, C19H15N3O4S, CAS 476281-64-8
4-(2,5-Dioxopyrrolidin-1-yl)-N-(4-methoxy-1,3-benzothiazol-2-yl)benzamide
CAS 476281-64-8C19H15N3O4S
Methyl 2-[4-(2,5-dioxopyrrolidin-1-yl)benzoyl]imino-3-(2-methoxyethyl)-1,3-benzothiazole-6-carboxylate chemical structure, C23H21N3O6S, CAS 864975-31-5
Methyl 2-[4-(2,5-dioxopyrrolidin-1-yl)benzoyl]imino-3-(2-methoxyethyl)-1,3-benzothiazole-6-carboxylate
CAS 864975-31-5C23H21N3O6S
4-(2,5-Dioxopyrrolidin-1-yl)-N-(6-methoxy-1,3-benzothiazol-2-yl)benzamide chemical structure, C19H15N3O4S, CAS 330191-20-3
4-(2,5-Dioxopyrrolidin-1-yl)-N-(6-methoxy-1,3-benzothiazol-2-yl)benzamide
CAS 330191-20-3C19H15N3O4S
(E)-4-(2,5-Dioxopyrrolidin-1-yl)-N-(4-ethoxy-3-ethylbenzo[d]thiazol-2(3H)-ylidene)benzamide chemical structure, C22H21N3O4S, CAS 864925-49-5
(E)-4-(2,5-Dioxopyrrolidin-1-yl)-N-(4-ethoxy-3-ethylbenzo[d]thiazol-2(3H)-ylidene)benzamide
CAS 864925-49-5C22H21N3O4S
(Z)-Ethyl 3-allyl-2-((4-(2,5-dioxopyrrolidin-1-yl)benzoyl)imino)-2,3-dihydrobenzo[d]thiazole-6-carboxylate chemical structure, C24H21N3O5S, CAS 865174-65-8
(Z)-Ethyl 3-allyl-2-((4-(2,5-dioxopyrrolidin-1-yl)benzoyl)imino)-2,3-dihydrobenzo[d]thiazole-6-carboxylate
CAS 865174-65-8C24H21N3O5S
(E)-4-(2,5-Dioxopyrrolidin-1-yl)-N-(6-methoxy-3-methylbenzo[d]thiazol-2(3H)-ylidene)benzamide chemical structure, C20H17N3O4S, CAS 681232-17-7
(E)-4-(2,5-Dioxopyrrolidin-1-yl)-N-(6-methoxy-3-methylbenzo[d]thiazol-2(3H)-ylidene)benzamide
CAS 681232-17-7C20H17N3O4S
(Z)-N-(3-Allyl-6-bromobenzo[d]thiazol-2(3H)-ylidene)-4-(2,5-dioxopyrrolidin-1-yl)benzamide chemical structure, C21H16BrN3O3S, CAS 865175-13-9
(Z)-N-(3-Allyl-6-bromobenzo[d]thiazol-2(3H)-ylidene)-4-(2,5-dioxopyrrolidin-1-yl)benzamide
CAS 865175-13-9C21H16BrN3O3S
(Z)-4-(2,5-Dioxopyrrolidin-1-yl)-N-(3-(2-methoxyethyl)-6-sulfamoylbenzo[d]thiazol-2(3H)-ylidene)benzamide chemical structure, C21H20N4O6S2, CAS 865159-95-1
(Z)-4-(2,5-Dioxopyrrolidin-1-yl)-N-(3-(2-methoxyethyl)-6-sulfamoylbenzo[d]thiazol-2(3H)-ylidene)benzamide
CAS 865159-95-1C21H20N4O6S2
(Z)-Ethyl 2-(2-((4-(2,5-dioxopyrrolidin-1-yl)benzoyl)imino)-6-sulfamoylbenzo[d]thiazol-3(2H)-yl)acetate chemical structure, C22H20N4O7S2, CAS 865247-85-4
(Z)-Ethyl 2-(2-((4-(2,5-dioxopyrrolidin-1-yl)benzoyl)imino)-6-sulfamoylbenzo[d]thiazol-3(2H)-yl)acetate
CAS 865247-85-4C22H20N4O7S2
(Z)-N-(6-Bromo-3-(2-methoxyethyl)benzo[d]thiazol-2(3H)-ylidene)-4-(2,5-dioxopyrrolidin-1-yl)benzamide chemical structure, C21H18BrN3O4S, CAS 864976-05-6
(Z)-N-(6-Bromo-3-(2-methoxyethyl)benzo[d]thiazol-2(3H)-ylidene)-4-(2,5-dioxopyrrolidin-1-yl)benzamide
CAS 864976-05-6C21H18BrN3O4S
(Z)-Ethyl 2-((4-(2,5-dioxopyrrolidin-1-yl)benzoyl)imino)-3-(2-methoxyethyl)-2,3-dihydrobenzo[d]thiazole-6-carboxylate chemical structure, C24H23N3O6S, CAS 864975-14-4
(Z)-Ethyl 2-((4-(2,5-dioxopyrrolidin-1-yl)benzoyl)imino)-3-(2-methoxyethyl)-2,3-dihydrobenzo[d]thiazole-6-carboxylate
CAS 864975-14-4C24H23N3O6S
N-(4,5-Dimethyl-1,3-benzothiazol-2-yl)-4-(2,5-dioxopyrrolidin-1-yl)benzamide chemical structure, C20H17N3O3S, CAS 864860-78-6
N-(4,5-Dimethyl-1,3-benzothiazol-2-yl)-4-(2,5-dioxopyrrolidin-1-yl)benzamide
CAS 864860-78-6C20H17N3O3S