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Murcko scaffold

Ring system with 4 rings and 25 atoms

20 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
20
With full pages
1
Scaffold SMILES

O=C(Nc1cccc(-c2ncnc3ccccc23)c1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1cccc(-c2ncnc3ccccc23)c1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 20 of 20 chemicals

N1-[3-[6,7-dimethoxy-2-(methylamino)-4-quinazolinyl]phenyl]-N4-methyl-1,4-benzenedicarboxamide chemical structure, C26H25N5O4, CAS 947620-52-2
N1-[3-[6,7-dimethoxy-2-(methylamino)-4-quinazolinyl]phenyl]-N4-methyl-1,4-benzenedicarboxamide
CAS 947620-52-2C26H25N5O4
Ethyl 4-(3-(6,7-dimethoxy-2-(methylamino)quinazolin-4-yl)phenylcarbamoyl)benzoate chemical structure, C27H26N4O5, CAS 947620-51-1
Ethyl 4-(3-(6,7-dimethoxy-2-(methylamino)quinazolin-4-yl)phenylcarbamoyl)benzoate
CAS 947620-51-1C27H26N4O5
Isopropyl 4-(3-(6,7-dimethoxy-2-(methylamino)quinazolin-4-yl)phenylcarbamoyl)benzoate chemical structure, C28H28N4O5, CAS 947620-54-4
Isopropyl 4-(3-(6,7-dimethoxy-2-(methylamino)quinazolin-4-yl)phenylcarbamoyl)benzoate
CAS 947620-54-4C28H28N4O5
Isopropyl 3-(3-(6,7-dimethoxy-2-(methylamino)quinazolin-4-yl)phenylcarbamoyl)benzoate chemical structure, C28H28N4O5, CAS 947620-62-4
Isopropyl 3-(3-(6,7-dimethoxy-2-(methylamino)quinazolin-4-yl)phenylcarbamoyl)benzoate
CAS 947620-62-4C28H28N4O5
2-Methoxyethyl 3-(3-(6,7-dimethoxy-2-(methylamino)quinazolin-4-yl)phenylcarbamoyl)benzoate chemical structure, C28H28N4O6, CAS 947620-68-0
2-Methoxyethyl 3-(3-(6,7-dimethoxy-2-(methylamino)quinazolin-4-yl)phenylcarbamoyl)benzoate
CAS 947620-68-0C28H28N4O6
Lotamilast chemical structure, C26H24N4O5, CAS 947620-48-6
Lotamilast
CAS 947620-48-6C26H24N4O5
4-[[[3-[6,7-Dimethoxy-2-(methylamino)-4-quinazolinyl]phenyl]amino]carbonyl]benzoic acid chemical structure, C25H22N4O5, CAS 947723-09-3
4-[[[3-[6,7-Dimethoxy-2-(methylamino)-4-quinazolinyl]phenyl]amino]carbonyl]benzoic acid
CAS 947723-09-3C25H22N4O5
N-[3-(6,7-Dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid hydrochloride chemical structure, C25H23ClN4O5, CAS 947620-49-7
N-[3-(6,7-Dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid hydrochloride
CAS 947620-49-7C25H23ClN4O5
N1-[3-[6,7-dimethoxy-2-(methylamino)-4-quinazolinyl]phenyl]-N3-propyl-1,3-benzenedicarboxamide chemical structure, C28H29N5O4, CAS 947620-65-7
N1-[3-[6,7-dimethoxy-2-(methylamino)-4-quinazolinyl]phenyl]-N3-propyl-1,3-benzenedicarboxamide
CAS 947620-65-7C28H29N5O4
2-Methoxyethyl 4-(3-(6,7-dimethoxy-2-(methylamino)quinazolin-4-yl)phenylcarbamoyl)benzoate chemical structure, C28H28N4O6, CAS 947620-67-9
2-Methoxyethyl 4-(3-(6,7-dimethoxy-2-(methylamino)quinazolin-4-yl)phenylcarbamoyl)benzoate
CAS 947620-67-9C28H28N4O6
N1-[3-[6,7-dimethoxy-2-(methylamino)-4-quinazolinyl]phenyl]-N3-methyl-1,3-benzenedicarboxamide chemical structure, C26H25N5O4, CAS 947620-63-5
N1-[3-[6,7-dimethoxy-2-(methylamino)-4-quinazolinyl]phenyl]-N3-methyl-1,3-benzenedicarboxamide
CAS 947620-63-5C26H25N5O4
N1-[3-[6,7-dimethoxy-2-(methylamino)-4-quinazolinyl]phenyl]-N4-propyl-1,4-benzenedicarboxamide chemical structure, C28H29N5O4, CAS 947620-56-6
N1-[3-[6,7-dimethoxy-2-(methylamino)-4-quinazolinyl]phenyl]-N4-propyl-1,4-benzenedicarboxamide
CAS 947620-56-6C28H29N5O4
N1-[3-[6,7-dimethoxy-2-(methylamino)-4-quinazolinyl]phenyl]-N3-ethyl-1,3-benzenedicarboxamide chemical structure, C27H27N5O4, CAS 947620-64-6
N1-[3-[6,7-dimethoxy-2-(methylamino)-4-quinazolinyl]phenyl]-N3-ethyl-1,3-benzenedicarboxamide
CAS 947620-64-6C27H27N5O4
N-[3-(6,7-Dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]-N',N'-dimethylterephthalamide chemical structure, C27H27N5O4, CAS 947620-50-0
N-[3-(6,7-Dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]-N',N'-dimethylterephthalamide
CAS 947620-50-0C27H27N5O4
N1-[3-[6,7-dimethoxy-2-(methylamino)-4-quinazolinyl]phenyl]-N4-ethyl-1,4-benzenedicarboxamide chemical structure, C27H27N5O4, CAS 947620-55-5
N1-[3-[6,7-dimethoxy-2-(methylamino)-4-quinazolinyl]phenyl]-N4-ethyl-1,4-benzenedicarboxamide
CAS 947620-55-5C27H27N5O4
3-[[[3-[6,7-Dimethoxy-2-(methylamino)-4-quinazolinyl]phenyl]amino]carbonyl]benzoic acid chemical structure, C25H22N4O5, CAS 947620-59-9
3-[[[3-[6,7-Dimethoxy-2-(methylamino)-4-quinazolinyl]phenyl]amino]carbonyl]benzoic acid
CAS 947620-59-9C25H22N4O5
Propyl 3-(3-(6,7-dimethoxy-2-(methylamino)quinazolin-4-yl)phenylcarbamoyl)benzoate chemical structure, C28H28N4O5, CAS 947620-61-3
Propyl 3-(3-(6,7-dimethoxy-2-(methylamino)quinazolin-4-yl)phenylcarbamoyl)benzoate
CAS 947620-61-3C28H28N4O5
Methyl 3-(3-(6,7-dimethoxy-2-(methylamino)quinazolin-4-yl)phenylcarbamoyl)benzoate chemical structure, C26H24N4O5, CAS 947620-58-8
Methyl 3-(3-(6,7-dimethoxy-2-(methylamino)quinazolin-4-yl)phenylcarbamoyl)benzoate
CAS 947620-58-8C26H24N4O5
Propyl 4-(3-(6,7-dimethoxy-2-(methylamino)quinazolin-4-yl)phenylcarbamoyl)benzoate chemical structure, C28H28N4O5, CAS 947620-53-3
Propyl 4-(3-(6,7-dimethoxy-2-(methylamino)quinazolin-4-yl)phenylcarbamoyl)benzoate
CAS 947620-53-3C28H28N4O5
Ethyl 3-(3-(6,7-dimethoxy-2-(methylamino)quinazolin-4-yl)phenylcarbamoyl)benzoate chemical structure, C27H26N4O5, CAS 947620-60-2
Ethyl 3-(3-(6,7-dimethoxy-2-(methylamino)quinazolin-4-yl)phenylcarbamoyl)benzoate
CAS 947620-60-2C27H26N4O5