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Murcko scaffold

Ring system with 4 rings and 24 atoms

30 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
30
With full pages
4
Scaffold SMILES

O=C1CC2CC(OC(=O)c3ccc(-c4ccccc4)cc3)CC2O1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CC2CC(OC(=O)c3ccc(-c4ccccc4)cc3)CC2O1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 30 of 30 chemicals

4-(Hydroxymethyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate chemical structure, C21H20O5, CAS 39265-57-1
4-(Hydroxymethyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate
CAS 39265-57-1C21H20O5
6-Iodo-4-(methoxymethyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate chemical structure, C22H21IO5, CAS 38361-03-4
6-Iodo-4-(methoxymethyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate
CAS 38361-03-4C22H21IO5
[4-(Hydroxymethyl)-2-oxo-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-5-yl] 4-phenylbenzoate chemical structure, C21H20O5, CAS 54382-73-9
[4-(Hydroxymethyl)-2-oxo-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-5-yl] 4-phenylbenzoate
CAS 54382-73-9C21H20O5
(1,1'-Biphenyl)-4-carboxylic acid, (3aR,4S,5R,6aS)-hexahydro-4-(hydroxymethyl)-2-oxo-2H-cyclopenta(b)furan-5-yl ester chemical structure, C21H20O5, CAS 31752-99-5
(1,1'-Biphenyl)-4-carboxylic acid, (3aR,4S,5R,6aS)-hexahydro-4-(hydroxymethyl)-2-oxo-2H-cyclopenta(b)furan-5-yl ester
CAS 31752-99-5C21H20O5
[2-Oxo-4-(3-oxooct-1-enyl)-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-5-yl] 4-phenylbenzoate chemical structure, C28H30O5, CAS 122921-58-8
[2-Oxo-4-(3-oxooct-1-enyl)-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-5-yl] 4-phenylbenzoate
CAS 122921-58-8C28H30O5
(3aR,4R,5R,6aS)-2-Oxo-4-((E)-3-oxooct-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate chemical structure, C28H30O5, CAS 31753-00-1
(3aR,4R,5R,6aS)-2-Oxo-4-((E)-3-oxooct-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate
CAS 31753-00-1C28H30O5
[1,1'-Biphenyl]-4-carboxylic acid, (3aR,4R,5R,6aS)-hexahydro-4-[(1E,3S)-3-hydroxy-1-octen-1-yl]-2-oxo-2H-cyclopenta[b]furan-5-yl ester chemical structure, C28H32O5, CAS 51014-26-7
[1,1'-Biphenyl]-4-carboxylic acid, (3aR,4R,5R,6aS)-hexahydro-4-[(1E,3S)-3-hydroxy-1-octen-1-yl]-2-oxo-2H-cyclopenta[b]furan-5-yl ester
CAS 51014-26-7C28H32O5
(3AR,4R,5R,6aS)-4-(hydroxymethyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate chemical structure, C21H20O5, CAS 2218532-68-2
(3AR,4R,5R,6aS)-4-(hydroxymethyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate
CAS 2218532-68-2C21H20O5
(3aR,4R,5R,6aS)-4-Formyl-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate chemical structure, C21H18O5, CAS 38754-71-1
(3aR,4R,5R,6aS)-4-Formyl-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate
CAS 38754-71-1C21H18O5
[(3aS,4S,5S,6aR)-2-Oxo-4-[(E)-3-oxooct-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-5-yl] 4-phenylbenzoate chemical structure, C28H30O5
[(3aS,4S,5S,6aR)-2-Oxo-4-[(E)-3-oxooct-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-5-yl] 4-phenylbenzoate
C28H30O5
(3aR,4R,5R,6aS)-Hexahydro-5-hydroxy-4-(3-oxo-1-decenyl)-2H-cyclopenta[b]furan-2-one 5-(4-Phenylbenzoate) chemical structure, C30H34O5, CAS 39865-76-4
(3aR,4R,5R,6aS)-Hexahydro-5-hydroxy-4-(3-oxo-1-decenyl)-2H-cyclopenta[b]furan-2-one 5-(4-Phenylbenzoate)
CAS 39865-76-4C30H34O5
(3aR,4R,5R,6aS)-2-Oxo-4-(3-oxodecyl)hexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate chemical structure, C30H36O5, CAS 120373-45-7
(3aR,4R,5R,6aS)-2-Oxo-4-(3-oxodecyl)hexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate
CAS 120373-45-7C30H36O5
(3AR,4R,5R,6AS)-4-((E)-4,4-difluoro-3-oxooct-1-en-1-yl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate chemical structure, C28H28F2O5, CAS 118583-35-0
(3AR,4R,5R,6AS)-4-((E)-4,4-difluoro-3-oxooct-1-en-1-yl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate
CAS 118583-35-0C28H28F2O5
[1,1'-Biphenyl]-4-carboxylic acid, 4-(4,4-difluoro-3-oxooctyl)hexahydro-2-oxo-2H-cyclopenta[b]furan-5-yl ester, [3aR-(3aalpha,4alpha,5beta,6aalpha)]- chemical structure, C28H30F2O5, CAS 118583-37-2
[1,1'-Biphenyl]-4-carboxylic acid, 4-(4,4-difluoro-3-oxooctyl)hexahydro-2-oxo-2H-cyclopenta[b]furan-5-yl ester, [3aR-(3aalpha,4alpha,5beta,6aalpha)]-
CAS 118583-37-2C28H30F2O5
R9Ynf3ZE5L chemical structure, C34H46F2O5Si, CAS 1392206-77-7
R9Ynf3ZE5L
CAS 1392206-77-7C34H46F2O5Si
[4-[(E)-3-[tert-Butyl(dimethyl)silyl]oxyoct-1-enyl]-2-oxo-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-5-yl] 4-phenylbenzoate chemical structure, C34H46O5Si
[4-[(E)-3-[tert-Butyl(dimethyl)silyl]oxyoct-1-enyl]-2-oxo-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-5-yl] 4-phenylbenzoate
C34H46O5Si
(3aR,4R,5R,6aS)-2-Oxo-4-(3-oxooct-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate chemical structure, C28H30O5
(3aR,4R,5R,6aS)-2-Oxo-4-(3-oxooct-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate
C28H30O5
[4-[3-[tert-Butyl(dimethyl)silyl]oxyoct-1-enyl]-2-oxo-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-5-yl] 4-phenylbenzoate chemical structure, C34H46O5Si
[4-[3-[tert-Butyl(dimethyl)silyl]oxyoct-1-enyl]-2-oxo-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-5-yl] 4-phenylbenzoate
C34H46O5Si
(3aR,4R,5R,6aS)-4-((S,E)-3-Hydroxy-3-methyloct-1-en-1-yl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate chemical structure, C29H34O5, CAS 42743-23-7
(3aR,4R,5R,6aS)-4-((S,E)-3-Hydroxy-3-methyloct-1-en-1-yl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate
CAS 42743-23-7C29H34O5
[(3aR,4R,5R,6aS)-4-[(E,3S)-3-[tert-Butyl(dimethyl)silyl]oxyoct-1-enyl]-2-oxo-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-5-yl] 4-phenylbenzoate chemical structure, C34H46O5Si
[(3aR,4R,5R,6aS)-4-[(E,3S)-3-[tert-Butyl(dimethyl)silyl]oxyoct-1-enyl]-2-oxo-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-5-yl] 4-phenylbenzoate
C34H46O5Si
VP5G8J6Qsk chemical structure, C27H34O5Si, CAS 64982-35-0
VP5G8J6Qsk
CAS 64982-35-0C27H34O5Si
NN2E8L3Whz chemical structure, C27H34O5Si, CAS 165876-61-9
NN2E8L3Whz
CAS 165876-61-9C27H34O5Si
[(3aS,4R,5R,6aR)-2-Oxo-4-(3-oxooct-1-enyl)-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-5-yl] 4-phenylbenzoate chemical structure, C28H30O5
[(3aS,4R,5R,6aR)-2-Oxo-4-(3-oxooct-1-enyl)-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-5-yl] 4-phenylbenzoate
C28H30O5
(3aS,4S,5S,6aR)-4-((S,E)-3-((tert-Butyldimethylsilyl)oxy)oct-1-en-1-yl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate chemical structure, C34H46O5Si, CAS 137624-47-6
(3aS,4S,5S,6aR)-4-((S,E)-3-((tert-Butyldimethylsilyl)oxy)oct-1-en-1-yl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate
CAS 137624-47-6C34H46O5Si