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Murcko scaffold

Ring system with 4 rings and 24 atoms

11 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
11
With full pages
6
Scaffold SMILES

O=C(CN1c2cccc3cccc(c23)S1(=O)=O)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CN1c2cccc3cccc(c23)S1(=O)=O)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 11 of 11 chemicals

2-(1,1-Dioxido-2H-naphtho[1,8-cd]isothiazol-2-yl)-N-(4-(trifluoromethoxy)phenyl)acetamide chemical structure, C19H13F3N2O4S, CAS 442658-33-5
2-(1,1-Dioxido-2H-naphtho[1,8-cd]isothiazol-2-yl)-N-(4-(trifluoromethoxy)phenyl)acetamide
CAS 442658-33-5C19H13F3N2O4S
N-(2-Bromophenyl)-2-(2,2-dioxo-2lambda6-thia-3-azatricyclo[6.3.1.04,12]dodeca-1(11),4,6,8(12),9-pentaen-3-yl)acetamide chemical structure, C18H13BrN2O3S, CAS 454189-23-2
N-(2-Bromophenyl)-2-(2,2-dioxo-2lambda6-thia-3-azatricyclo[6.3.1.04,12]dodeca-1(11),4,6,8(12),9-pentaen-3-yl)acetamide
CAS 454189-23-2C18H13BrN2O3S
2-(2,2-Dioxo-2lambda6-thia-3-azatricyclo[6.3.1.04,12]dodeca-1(11),4,6,8(12),9-pentaen-3-yl)-N-(4-methylphenyl)acetamide chemical structure, C19H16N2O3S, CAS 474077-28-6
2-(2,2-Dioxo-2lambda6-thia-3-azatricyclo[6.3.1.04,12]dodeca-1(11),4,6,8(12),9-pentaen-3-yl)-N-(4-methylphenyl)acetamide
CAS 474077-28-6C19H16N2O3S
2-(2,2-Dioxo-2lambda6-thia-3-azatricyclo[6.3.1.04,12]dodeca-1(11),4,6,8(12),9-pentaen-3-yl)-N-(2,3,4,5,6-pentafluorophenyl)acetamide chemical structure, C18H9F5N2O3S, CAS 380486-23-7
2-(2,2-Dioxo-2lambda6-thia-3-azatricyclo[6.3.1.04,12]dodeca-1(11),4,6,8(12),9-pentaen-3-yl)-N-(2,3,4,5,6-pentafluorophenyl)acetamide
CAS 380486-23-7C18H9F5N2O3S
N-(2-Cyanoethyl)-2-(2,2-dioxo-2lambda6-thia-3-azatricyclo[6.3.1.04,12]dodeca-1(11),4,6,8(12),9-pentaen-3-yl)-N-phenylacetamide chemical structure, C21H17N3O3S, CAS 452943-92-9
N-(2-Cyanoethyl)-2-(2,2-dioxo-2lambda6-thia-3-azatricyclo[6.3.1.04,12]dodeca-1(11),4,6,8(12),9-pentaen-3-yl)-N-phenylacetamide
CAS 452943-92-9C21H17N3O3S
N-(4-Acetylphenyl)-2-(2,2-dioxo-2lambda6-thia-3-azatricyclo[6.3.1.04,12]dodeca-1(11),4,6,8(12),9-pentaen-3-yl)acetamide chemical structure, C20H16N2O4S, CAS 436832-20-1
N-(4-Acetylphenyl)-2-(2,2-dioxo-2lambda6-thia-3-azatricyclo[6.3.1.04,12]dodeca-1(11),4,6,8(12),9-pentaen-3-yl)acetamide
CAS 436832-20-1C20H16N2O4S
N-(2,5-Dimethoxyphenyl)-2-(2,2-dioxo-2lambda6-thia-3-azatricyclo[6.3.1.04,12]dodeca-1(11),4,6,8(12),9-pentaen-3-yl)acetamide chemical structure, C20H18N2O5S, CAS 455291-65-3
N-(2,5-Dimethoxyphenyl)-2-(2,2-dioxo-2lambda6-thia-3-azatricyclo[6.3.1.04,12]dodeca-1(11),4,6,8(12),9-pentaen-3-yl)acetamide
CAS 455291-65-3C20H18N2O5S
2-(2,2-Dioxo-2lambda6-thia-3-azatricyclo[6.3.1.04,12]dodeca-1(11),4,6,8(12),9-pentaen-3-yl)-N-(2,3,4-trifluorophenyl)acetamide chemical structure, C18H11F3N2O3S, CAS 454198-45-9
2-(2,2-Dioxo-2lambda6-thia-3-azatricyclo[6.3.1.04,12]dodeca-1(11),4,6,8(12),9-pentaen-3-yl)-N-(2,3,4-trifluorophenyl)acetamide
CAS 454198-45-9C18H11F3N2O3S
N-(3,4-Dimethylphenyl)-2-(1,1-dioxido-2H-naphtho[1,8-cd]isothiazol-2-yl)propanamide chemical structure, C21H20N2O3S, CAS 824974-60-9
N-(3,4-Dimethylphenyl)-2-(1,1-dioxido-2H-naphtho[1,8-cd]isothiazol-2-yl)propanamide
CAS 824974-60-9C21H20N2O3S
N-(2,5-Dichlorophenyl)-2-(1,1-dioxido-2H-naphtho[1,8-cd]isothiazol-2-yl)propanamide chemical structure, C19H14Cl2N2O3S, CAS 826997-02-8
N-(2,5-Dichlorophenyl)-2-(1,1-dioxido-2H-naphtho[1,8-cd]isothiazol-2-yl)propanamide
CAS 826997-02-8C19H14Cl2N2O3S
N-(3,4-Dimethoxy-phenyl)-2-(1,1-dioxo-1H-1lambda*6*-naphtho[1,8-cd]isothiazol-2-yl)-propionamide chemical structure, C21H20N2O5S, CAS 717827-69-5
N-(3,4-Dimethoxy-phenyl)-2-(1,1-dioxo-1H-1lambda*6*-naphtho[1,8-cd]isothiazol-2-yl)-propionamide
CAS 717827-69-5C21H20N2O5S