Murcko scaffold
Ring system with 5 rings and 25 atoms
18 chemicals on CompoundList share this ring system.
- Rings
- 5
- Scaffold atoms
- 25
- Chemicals
- 18
- With full pages
- 4
Scaffold SMILES
c1ccc(-c2nc3c(cnn3-c3ccccc3)c3ccccc23)cc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 18 of 18 chemicals
![7,8-Dimethoxy-5-(2-methoxyphenyl)-3-phenyl-3H-pyrazolo[3,4-c]isoquinoline chemical structure, C25H21N3O3, CAS 887582-31-2](/s/VTHVWSIOLBJLPP-UHFFFAOYSA-N.svg)
7,8-Dimethoxy-5-(2-methoxyphenyl)-3-phenyl-3H-pyrazolo[3,4-c]isoquinoline
CAS 887582-31-2C25H21N3O3
![7,8-Dimethoxy-5-(3-methoxyphenyl)-3-phenyl-3H-pyrazolo[3,4-c]isoquinoline chemical structure, C25H21N3O3, CAS 887582-39-0](/s/ITFIZPWRFHUKEO-UHFFFAOYSA-N.svg)
7,8-Dimethoxy-5-(3-methoxyphenyl)-3-phenyl-3H-pyrazolo[3,4-c]isoquinoline
CAS 887582-39-0C25H21N3O3
![7,8-Dimethoxy-5-(4-methoxyphenyl)-3-phenyl-3H-pyrazolo[3,4-c]isoquinoline chemical structure, C25H21N3O3, CAS 887574-14-3](/s/QRDSMJSHOAEYGZ-UHFFFAOYSA-N.svg)
7,8-Dimethoxy-5-(4-methoxyphenyl)-3-phenyl-3H-pyrazolo[3,4-c]isoquinoline
CAS 887574-14-3C25H21N3O3
![5-(2,5-Dimethoxyphenyl)-7,8-dimethoxy-3-phenyl-3H-pyrazolo[3,4-c]isoquinoline chemical structure, C26H23N3O4, CAS 887582-47-0](/s/VTGBILURYITJTM-UHFFFAOYSA-N.svg)
5-(2,5-Dimethoxyphenyl)-7,8-dimethoxy-3-phenyl-3H-pyrazolo[3,4-c]isoquinoline
CAS 887582-47-0C26H23N3O4
![5-(3,4-Dimethoxyphenyl)-7,8-dimethoxy-3-phenyl-3H-pyrazolo[3,4-c]isoquinoline chemical structure, C26H23N3O4, CAS 887582-55-0](/s/FHKTXCGDMDZUPU-UHFFFAOYSA-N.svg)
5-(3,4-Dimethoxyphenyl)-7,8-dimethoxy-3-phenyl-3H-pyrazolo[3,4-c]isoquinoline
CAS 887582-55-0C26H23N3O4
![5-(2-Bromo-4,5-dimethoxyphenyl)-7,8-dimethoxy-1-methyl-3-phenylpyrazolo[3,4-c]isoquinoline chemical structure, C27H24BrN3O4, CAS 334498-80-5](/s/LYLQVVFIDCSALD-UHFFFAOYSA-N.svg)
5-(2-Bromo-4,5-dimethoxyphenyl)-7,8-dimethoxy-1-methyl-3-phenylpyrazolo[3,4-c]isoquinoline
CAS 334498-80-5C27H24BrN3O4
![5-(4-Ethoxyphenyl)-7,8-dimethoxy-1-methyl-3-phenylpyrazolo[3,4-c]isoquinoline chemical structure, C27H25N3O3, CAS 337503-61-4](/s/SMZNYKDZIMNKJH-UHFFFAOYSA-N.svg)
5-(4-Ethoxyphenyl)-7,8-dimethoxy-1-methyl-3-phenylpyrazolo[3,4-c]isoquinoline
CAS 337503-61-4C27H25N3O3
![2-Ethoxy-4-(1-ethyl-7,8-dimethoxy-3-phenyl-3H-pyrazolo[3,4-c]isoquinolin-5-yl)phenol chemical structure, C28H27N3O4, CAS 337503-63-6](/s/UZYKOHRWQAATGI-UHFFFAOYSA-N.svg)
2-Ethoxy-4-(1-ethyl-7,8-dimethoxy-3-phenyl-3H-pyrazolo[3,4-c]isoquinolin-5-yl)phenol
CAS 337503-63-6C28H27N3O4
![5-(4-Ethoxyphenyl)-1-ethyl-7,8-dimethoxy-3-phenylpyrazolo[3,4-c]isoquinoline chemical structure, C28H27N3O3, CAS 337503-67-0](/s/XZICFNUUPYJMMW-UHFFFAOYSA-N.svg)
5-(4-Ethoxyphenyl)-1-ethyl-7,8-dimethoxy-3-phenylpyrazolo[3,4-c]isoquinoline
CAS 337503-67-0C28H27N3O3
![4-(1-Ethyl-7,8-dimethoxy-3-phenylpyrazolo[3,4-c]isoquinolin-5-yl)-N,N-dimethylaniline chemical structure, C28H28N4O2, CAS 332351-90-3](/s/QXAMYWMTJRONBG-UHFFFAOYSA-N.svg)
4-(1-Ethyl-7,8-dimethoxy-3-phenylpyrazolo[3,4-c]isoquinolin-5-yl)-N,N-dimethylaniline
CAS 332351-90-3C28H28N4O2
![7,8-Dimethoxy-5-(2-methoxyphenyl)-1-methyl-3-phenyl-3H-pyrazolo[3,4-c]isoquinoline chemical structure, C26H23N3O3, CAS 353460-71-6](/s/DLNMVHXVMQPHJQ-UHFFFAOYSA-N.svg)
7,8-Dimethoxy-5-(2-methoxyphenyl)-1-methyl-3-phenyl-3H-pyrazolo[3,4-c]isoquinoline
CAS 353460-71-6C26H23N3O3
![5-(2-Chlorophenyl)-7,8-dimethoxy-1-methyl-3-phenyl-3H-pyrazolo[3,4-c]isoquinoline chemical structure, C25H20ClN3O2, CAS 353461-13-9](/s/WDWFNPVEERMAJN-UHFFFAOYSA-N.svg)
5-(2-Chlorophenyl)-7,8-dimethoxy-1-methyl-3-phenyl-3H-pyrazolo[3,4-c]isoquinoline
CAS 353461-13-9C25H20ClN3O2
![6-(7,8-Dimethoxy-1-methyl-3-phenyl-2H-pyrazolo[3,4-c]isoquinolin-5-ylidene)-1-cyclohexa-2,4-dienone chemical structure, C25H21N3O3, CAS 376620-85-8](/s/POEUIJCVSFDDFS-UHFFFAOYSA-N.svg)
6-(7,8-Dimethoxy-1-methyl-3-phenyl-2H-pyrazolo[3,4-c]isoquinolin-5-ylidene)-1-cyclohexa-2,4-dienone
CAS 376620-85-8C25H21N3O3
![5-(3,4-Diethoxyphenyl)-1-ethyl-7,8-dimethoxy-3-phenylpyrazolo[3,4-c]isoquinoline chemical structure, C30H31N3O4, CAS 337503-65-8](/s/AXFZUEGYLSFVIS-UHFFFAOYSA-N.svg)
5-(3,4-Diethoxyphenyl)-1-ethyl-7,8-dimethoxy-3-phenylpyrazolo[3,4-c]isoquinoline
CAS 337503-65-8C30H31N3O4
![5-(2-Bromophenyl)-7,8-dimethoxy-1-methyl-3-phenyl-3H-pyrazolo[3,4-c]isoquinoline chemical structure, C25H20BrN3O2, CAS 376611-37-9](/s/DACJXLQPKGMTTO-UHFFFAOYSA-N.svg)
5-(2-Bromophenyl)-7,8-dimethoxy-1-methyl-3-phenyl-3H-pyrazolo[3,4-c]isoquinoline
CAS 376611-37-9C25H20BrN3O2
![5-(2-Bromo-4,5-dimethoxyphenyl)-1-ethyl-7,8-dimethoxy-3-phenyl-3H-pyrazolo[3,4-c]isoquinoline chemical structure, C28H26BrN3O4, CAS 423731-97-9](/s/FJFJPBLRJTWXLG-UHFFFAOYSA-N.svg)
5-(2-Bromo-4,5-dimethoxyphenyl)-1-ethyl-7,8-dimethoxy-3-phenyl-3H-pyrazolo[3,4-c]isoquinoline
CAS 423731-97-9C28H26BrN3O4
![1-Ethyl-7,8-dimethoxy-5-(4-methoxyphenyl)-3-phenylpyrazolo[3,4-c]isoquinoline chemical structure, C27H25N3O3, CAS 5934-48-5](/s/ZYTYDKHALPAXNK-UHFFFAOYSA-N.svg)
1-Ethyl-7,8-dimethoxy-5-(4-methoxyphenyl)-3-phenylpyrazolo[3,4-c]isoquinoline
CAS 5934-48-5C27H25N3O3
![5-(4-Bromophenyl)-7,8-dimethoxy-1-methyl-3-phenylpyrazolo[3,4-c]isoquinoline chemical structure, C25H20BrN3O2, CAS 334498-79-2](/s/VTRXKPNXTAKQBW-UHFFFAOYSA-N.svg)
5-(4-Bromophenyl)-7,8-dimethoxy-1-methyl-3-phenylpyrazolo[3,4-c]isoquinoline
CAS 334498-79-2C25H20BrN3O2
Related scaffolds
Same ring framework with different atoms or bond orders
