Murcko scaffold
Ring system with 5 rings and 33 atoms
24 chemicals on CompoundList share this ring system.
- Rings
- 5
- Scaffold atoms
- 33
- Chemicals
- 24
- With full pages
- 1
Scaffold SMILES
O=c1ccn(C2CC(OC(c3ccccc3)(c3ccccc3)c3ccccc3)CO2)c(=O)[nH]1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
![Murcko scaffold O=c1ccn(C2CC(OC(c3ccccc3)(c3ccccc3)c3ccccc3)CO2)c(=O)[nH]1](/scaffold/MKIIXBSKBWLGTB-UHFFFAOYSA-N/structure.svg)
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 24 of 24 chemicals
3'-O-(4,4'-Dimethoxytrityl)-thymidine
CAS 76054-81-4C31H32N2O7
RefChem:388725
CAS 13084-61-2C30H30N2O6
3'-O-(4,4'-Dimethoxytrityl)-2'-O-(2-methoxyethyl)-5-methyluridine
CAS 1345715-42-5C34H38N2O9
![5'-O-Acetyl-3'-O-[bis(4-methoxyphenyl)(phenyl)methyl]thymidine chemical structure, C33H34N2O8, CAS 76054-82-5](/s/GUNWBDODWSETGG-FRXPANAUSA-N.svg)
5'-O-Acetyl-3'-O-[bis(4-methoxyphenyl)(phenyl)methyl]thymidine
CAS 76054-82-5C33H34N2O8
![1-[(2R,3R,4S)-4-[Bis(4-methoxyphenyl)-phenylmethoxy]-3-hydroxyoxolan-2-yl]pyrimidine-2,4-dione chemical structure, C29H28N2O7, CAS 325683-90-7](/s/ZAFYDTSNKMUVJC-WYMJOSIYSA-N.svg)
1-[(2R,3R,4S)-4-[Bis(4-methoxyphenyl)-phenylmethoxy]-3-hydroxyoxolan-2-yl]pyrimidine-2,4-dione
CAS 325683-90-7C29H28N2O7
![1-(3'-O-[4,4'-Dimethoxytrityl]-alpha-L-threofuranosyl)-thymine chemical structure, C30H30N2O7, CAS 325683-89-4](/s/JPMBAMZBKIFKDJ-ZRRKCSAHSA-N.svg)
1-(3'-O-[4,4'-Dimethoxytrityl]-alpha-L-threofuranosyl)-thymine
CAS 325683-89-4C30H30N2O7
DMTr-TNA-5MeU amidite
CAS 325683-94-1C39H47N4O8P
DMTr-TNA-U amidite
CAS 325683-95-2C38H45N4O8P
4-(((2R,3S,5R)-3-(Bis(4-methoxyphenyl)(phenyl)methoxy)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methoxy)-4-oxobutanoic acid
CAS 140839-25-4C35H36N2O10
Rev 2'-O-MOE-5MeU-5'-amidite
CAS 1345715-43-6C43H55N4O10P
![4-[[(2R,3R,4R,5R)-3-[Bis(4-methoxyphenyl)-phenylmethoxy]-5-(2,4-dioxopyrimidin-1-yl)-4-fluorooxolan-2-yl]methoxy]-4-oxobutanoic acid, N,N-diethylethanamine chemical structure, C40H48FN3O10, CAS 2738377-34-7](/s/ZGHHQPDHTIWFBI-GNGCXMSBSA-N.svg)
4-[[(2R,3R,4R,5R)-3-[Bis(4-methoxyphenyl)-phenylmethoxy]-5-(2,4-dioxopyrimidin-1-yl)-4-fluorooxolan-2-yl]methoxy]-4-oxobutanoic acid, N,N-diethylethanamine
CAS 2738377-34-7C40H48FN3O10
4-(((2R,3R,4R,5R)-3-(Bis(4-methoxyphenyl)(phenyl)methoxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-2-yl)methoxy)-4-oxobutanoic acid
CAS 2738377-33-6C34H33FN2O10
![4-[[(2R,3R,4R,5R)-3-[Bis(4-methoxyphenyl)-phenylmethoxy]-4-[tert-butyl(dimethyl)silyl]oxy-5-(2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]-4-oxobutanoic acid chemical structure, C40H48N2O11Si, CAS 1214886-19-7](/s/YWNDZJMFTOBULP-MCNAWRSPSA-N.svg)
4-[[(2R,3R,4R,5R)-3-[Bis(4-methoxyphenyl)-phenylmethoxy]-4-[tert-butyl(dimethyl)silyl]oxy-5-(2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]-4-oxobutanoic acid
CAS 1214886-19-7C40H48N2O11Si
![3-[[3-[Bis(4-methoxyphenyl)-phenylmethoxy]-5-(2,4-dioxopyrimidin-1-yl)-4-methoxyoxolan-2-yl]methoxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile chemical structure, C40H49N4O9P](/s/ATKRAEVWEXDALJ-UHFFFAOYSA-N.svg)
3-[[3-[Bis(4-methoxyphenyl)-phenylmethoxy]-5-(2,4-dioxopyrimidin-1-yl)-4-methoxyoxolan-2-yl]methoxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
C40H49N4O9P
![2'-Deoxy-5'-O-[(1,1-dimethylethyl)dimethylsilyl]-4'-C-ethenyl-2'-fluoro-3'-O-[(4-methoxyphenyl)diphenylmethyl]uridine chemical structure, C37H43FN2O6Si, CAS 1846562-86-4](/s/NDXKFELYFLNWIF-BJGHAWMQSA-N.svg)
2'-Deoxy-5'-O-[(1,1-dimethylethyl)dimethylsilyl]-4'-C-ethenyl-2'-fluoro-3'-O-[(4-methoxyphenyl)diphenylmethyl]uridine
CAS 1846562-86-4C37H43FN2O6Si
![1-[(2R,3S,4R,5R)-5-[[tert-Butyl(dimethyl)silyl]oxymethyl]-3-fluoro-5-(fluoromethyl)-4-[(4-methoxyphenyl)-diphenylmethoxy]oxolan-2-yl]pyrimidine-2,4-dione chemical structure, C36H42F2N2O6Si, CAS 1948281-58-0](/s/MOTGGYCRPJWINP-DCERFKFHSA-N.svg)
1-[(2R,3S,4R,5R)-5-[[tert-Butyl(dimethyl)silyl]oxymethyl]-3-fluoro-5-(fluoromethyl)-4-[(4-methoxyphenyl)-diphenylmethoxy]oxolan-2-yl]pyrimidine-2,4-dione
CAS 1948281-58-0C36H42F2N2O6Si
![1-[2-Deoxy-2-fluoro-4-C-(fluoromethyl)-3-O-[(4-methoxyphenyl)diphenylmethyl]-|A-Darabinofuranosyl]-2,4(1H,3H)-pyrimidinedione chemical structure, C30H28F2N2O6, CAS 1948281-57-9](/s/RYGHDPWVFLUQPB-YJIPECKFSA-N.svg)
1-[2-Deoxy-2-fluoro-4-C-(fluoromethyl)-3-O-[(4-methoxyphenyl)diphenylmethyl]-|A-Darabinofuranosyl]-2,4(1H,3H)-pyrimidinedione
CAS 1948281-57-9C30H28F2N2O6
![2'-Deoxy-5'-O-[(1,1-dimethylethyl)dimethylsilyl]-2',2'-difluoro-4'-C-(fluoromethyl)-3'-O-[(4-methoxyphenyl)diphenylmethyl]uridine chemical structure, C36H41F3N2O6Si, CAS 1643585-85-6](/s/FENSAIINJZPLFV-MUZHKWOHSA-N.svg)
2'-Deoxy-5'-O-[(1,1-dimethylethyl)dimethylsilyl]-2',2'-difluoro-4'-C-(fluoromethyl)-3'-O-[(4-methoxyphenyl)diphenylmethyl]uridine
CAS 1643585-85-6C36H41F3N2O6Si
![2'-Deoxy-2',2'-difluoro-4'-C-(fluoromethyl)-3'-O-[(4-methoxyphenyl)diphenylmethyl]uridine chemical structure, C30H27F3N2O6, CAS 1643585-84-5](/s/ABDCGHLTKQPBFQ-STROYTFGSA-N.svg)
2'-Deoxy-2',2'-difluoro-4'-C-(fluoromethyl)-3'-O-[(4-methoxyphenyl)diphenylmethyl]uridine
CAS 1643585-84-5C30H27F3N2O6
![2'-Deoxy-2'-fluoro-4'-C-(fluoromethyl)-3'-O-[(4-methoxyphenyl)diphenylmethyl]uridine chemical structure, C30H28F2N2O6, CAS 1445396-76-8](/s/RYGHDPWVFLUQPB-LLNGEMMXSA-N.svg)
2'-Deoxy-2'-fluoro-4'-C-(fluoromethyl)-3'-O-[(4-methoxyphenyl)diphenylmethyl]uridine
CAS 1445396-76-8C30H28F2N2O6
Rev 2'-F-ara-U-5'-amidite
CAS 3025999-67-8C39H46FN4O8P
1-((2R,3R,4R,5R)-4-(Bis(4-methoxyphenyl)(phenyl)methoxy)-3-fluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
CAS 2305979-77-3C30H29FN2O7
Cytidine impurity 59
CAS 2721427-32-1C40H49N4O9P
Orb3237621
C39H46FN4O8P