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Murcko scaffold

Ring system with 3 rings and 17 atoms

29 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
17
Chemicals
29
With full pages
3
Scaffold SMILES

c1ccc(-c2cn(-c3ccccc3)cn2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-c2cn(-c3ccccc3)cn2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 29 of 29 chemicals

1H-Imidazole, 1-(4-methoxyphenyl)-4-(4-nitrophenyl)- chemical structure, C16H13N3O3, CAS 97814-23-8
1H-Imidazole, 1-(4-methoxyphenyl)-4-(4-nitrophenyl)-
CAS 97814-23-8C16H13N3O3
N-Ethyl-4,5-dimethyl-2-[4-(4-nitrophenyl)imidazol-1-yl]aniline chemical structure, C19H20N4O2, CAS 82040-24-2
N-Ethyl-4,5-dimethyl-2-[4-(4-nitrophenyl)imidazol-1-yl]aniline
CAS 82040-24-2C19H20N4O2
Ethyl 2-[4-(4-methylphenyl)-1-phenylimidazol-2-yl]sulfanylacetate chemical structure, C20H20N2O2S, CAS 306278-80-8
Ethyl 2-[4-(4-methylphenyl)-1-phenylimidazol-2-yl]sulfanylacetate
CAS 306278-80-8C20H20N2O2S
2-[4-(4-Methoxyphenyl)-1H-imidazol-1-yl]-N-methyl-4-nitroaniline chemical structure, C17H16N4O3, CAS 5855-67-4
2-[4-(4-Methoxyphenyl)-1H-imidazol-1-yl]-N-methyl-4-nitroaniline
CAS 5855-67-4C17H16N4O3
1-(4-Bromophenyl)-4-phenylimidazole chemical structure, C15H11BrN2, CAS 79221-05-9
1-(4-Bromophenyl)-4-phenylimidazole
CAS 79221-05-9C15H11BrN2
4-(4-Chlorophenyl)-2-[(difluoromethyl)thio]-1-(2-methylphenyl)-1H-imidazole chemical structure, C17H13ClF2N2S, CAS 379727-17-0
4-(4-Chlorophenyl)-2-[(difluoromethyl)thio]-1-(2-methylphenyl)-1H-imidazole
CAS 379727-17-0C17H13ClF2N2S
1-(4-Methoxyphenyl)-5-methyl-3-oxo-4-phenyl-1H-3lambda~5~-imidazole chemical structure, C17H16N2O2, CAS 63235-59-6
1-(4-Methoxyphenyl)-5-methyl-3-oxo-4-phenyl-1H-3lambda~5~-imidazole
CAS 63235-59-6C17H16N2O2
3-(4-Phenyl-1H-imidazol-1-yl)phenol chemical structure, C15H12N2O, CAS 79221-00-4
3-(4-Phenyl-1H-imidazol-1-yl)phenol
CAS 79221-00-4C15H12N2O
1-(4-Chlorophenyl)-4-phenyl-1H-imidazole chemical structure, C15H11ClN2, CAS 79221-06-0
1-(4-Chlorophenyl)-4-phenyl-1H-imidazole
CAS 79221-06-0C15H11ClN2
1-(4-Fluorophenyl)-4-(4-nitrophenyl)-1H-imidazole chemical structure, C15H10FN3O2, CAS 114660-47-8
1-(4-Fluorophenyl)-4-(4-nitrophenyl)-1H-imidazole
CAS 114660-47-8C15H10FN3O2
4-(4-Nitrophenyl)-1-[3-(trifluoromethyl)phenyl]-1H-imidazole chemical structure, C16H10F3N3O2, CAS 114660-51-4
4-(4-Nitrophenyl)-1-[3-(trifluoromethyl)phenyl]-1H-imidazole
CAS 114660-51-4C16H10F3N3O2
3-(4-Phenyl-imidazol-1-yl)-benzonitrile chemical structure, C16H11N3, CAS 934633-47-3
3-(4-Phenyl-imidazol-1-yl)-benzonitrile
CAS 934633-47-3C16H11N3
N-{3-[4-(3-Methoxy-phenyl)-imidazol-1-yl]-phenyl}-acetamide chemical structure, C18H17N3O2, CAS 934633-37-1
N-{3-[4-(3-Methoxy-phenyl)-imidazol-1-yl]-phenyl}-acetamide
CAS 934633-37-1C18H17N3O2
N-{3-[4-(3-Cyano-phenyl)-imidazol-1-yl]-phenyl}-acetamide chemical structure, C18H14N4O, CAS 934633-39-3
N-{3-[4-(3-Cyano-phenyl)-imidazol-1-yl]-phenyl}-acetamide
CAS 934633-39-3C18H14N4O
N-{3-[4-(2-Methoxy-phenyl)-imidazol-1-yl]-phenyl}-acetamide chemical structure, C18H17N3O2, CAS 934633-43-9
N-{3-[4-(2-Methoxy-phenyl)-imidazol-1-yl]-phenyl}-acetamide
CAS 934633-43-9C18H17N3O2
3-[4-(3-Methoxy-phenyl)-imidazol-1-yl]-phenylamine chemical structure, C16H15N3O, CAS 934633-45-1
3-[4-(3-Methoxy-phenyl)-imidazol-1-yl]-phenylamine
CAS 934633-45-1C16H15N3O
4-[2-(1,1-Dimethylethyl)-4-phenyl-1H-imidazol-1-yl]benzeneethanol chemical structure, C21H24N2O, CAS 616893-63-1
4-[2-(1,1-Dimethylethyl)-4-phenyl-1H-imidazol-1-yl]benzeneethanol
CAS 616893-63-1C21H24N2O
4-[2-Ethyl-4-(4-methylphenyl)-1H-imidazol-1-yl]benzeneethanol chemical structure, C20H22N2O, CAS 616893-87-9
4-[2-Ethyl-4-(4-methylphenyl)-1H-imidazol-1-yl]benzeneethanol
CAS 616893-87-9C20H22N2O
2-(4-(2-Isopropyl-4-phenyl-1H-imidazol-1-yl)phenyl)ethan-1-ol chemical structure, C20H22N2O, CAS 616893-52-8
2-(4-(2-Isopropyl-4-phenyl-1H-imidazol-1-yl)phenyl)ethan-1-ol
CAS 616893-52-8C20H22N2O
1-(4-(2-Chloroethyl)phenyl)-2-isopropyl-4-phenyl-1H-imidazole chemical structure, C20H21ClN2, CAS 616893-56-2
1-(4-(2-Chloroethyl)phenyl)-2-isopropyl-4-phenyl-1H-imidazole
CAS 616893-56-2C20H21ClN2
4-(4-Phenyl-1H-imidazol-1-yl)benzoic acid chemical structure, C16H12N2O2, CAS 885015-93-0
4-(4-Phenyl-1H-imidazol-1-yl)benzoic acid
CAS 885015-93-0C16H12N2O2
4,4'-(1H-Imidazole-1,4-diyl)dianiline chemical structure, C15H14N4, CAS 141915-52-8
4,4'-(1H-Imidazole-1,4-diyl)dianiline
CAS 141915-52-8C15H14N4
3-Chloro-4-(4-phenylimidazol-1-yl)benzoic acid chemical structure, C16H11ClN2O2, CAS 1578191-21-5
3-Chloro-4-(4-phenylimidazol-1-yl)benzoic acid
CAS 1578191-21-5C16H11ClN2O2
4-(5-Methyl-4-phenylimidazol-1-yl)benzoic acid chemical structure, C17H14N2O2, CAS 1578191-23-7
4-(5-Methyl-4-phenylimidazol-1-yl)benzoic acid
CAS 1578191-23-7C17H14N2O2