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Murcko scaffold

Ring system with 2 rings and 16 atoms

12 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
16
Chemicals
12
With full pages
10
Scaffold SMILES

O=C1CN(C(=S)Nc2ccccc2)CCN1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CN(C(=S)Nc2ccccc2)CCN1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

Methyl (1-{[(3-methylphenyl)amino]carbonothioyl}-3-oxo-2-piperazinyl)acetate chemical structure, C15H19N3O3S, CAS 1009236-31-0
Methyl (1-{[(3-methylphenyl)amino]carbonothioyl}-3-oxo-2-piperazinyl)acetate
CAS 1009236-31-0C15H19N3O3S
Methyl 2-(1-{[(2-ethylphenyl)amino]thioxomethyl}-3-oxopiperazin-2-yl)acetate chemical structure, C16H21N3O3S, CAS 1008865-35-7
Methyl 2-(1-{[(2-ethylphenyl)amino]thioxomethyl}-3-oxopiperazin-2-yl)acetate
CAS 1008865-35-7C16H21N3O3S
Methyl {1-[(3-methoxyphenyl)carbamothioyl]-3-oxopiperazin-2-yl}acetate chemical structure, C15H19N3O4S, CAS 1092797-54-0
Methyl {1-[(3-methoxyphenyl)carbamothioyl]-3-oxopiperazin-2-yl}acetate
CAS 1092797-54-0C15H19N3O4S
Methyl (1-{[(4-chlorophenyl)amino]carbonothioyl}-3-oxo-2-piperazinyl)acetate chemical structure, C14H16ClN3O3S, CAS 1009488-96-3
Methyl (1-{[(4-chlorophenyl)amino]carbonothioyl}-3-oxo-2-piperazinyl)acetate
CAS 1009488-96-3C14H16ClN3O3S
Methyl (3-oxo-1-{[3-(trifluoromethyl)phenyl]carbamothioyl}piperazin-2-yl)acetate chemical structure, C15H16F3N3O3S, CAS 4903-83-7
Methyl (3-oxo-1-{[3-(trifluoromethyl)phenyl]carbamothioyl}piperazin-2-yl)acetate
CAS 4903-83-7C15H16F3N3O3S
Methyl {1-[(3,5-dimethylphenyl)carbamothioyl]-3-oxopiperazin-2-yl}acetate chemical structure, C16H21N3O3S, CAS 1009166-32-8
Methyl {1-[(3,5-dimethylphenyl)carbamothioyl]-3-oxopiperazin-2-yl}acetate
CAS 1009166-32-8C16H21N3O3S
Methyl {1-[(2-chlorophenyl)carbamothioyl]-3-oxopiperazin-2-yl}acetate chemical structure, C14H16ClN3O3S, CAS 1009183-64-5
Methyl {1-[(2-chlorophenyl)carbamothioyl]-3-oxopiperazin-2-yl}acetate
CAS 1009183-64-5C14H16ClN3O3S
Methyl {1-[(4-ethylphenyl)carbamothioyl]-3-oxopiperazin-2-yl}acetate chemical structure, C16H21N3O3S, CAS 1008955-21-2
Methyl {1-[(4-ethylphenyl)carbamothioyl]-3-oxopiperazin-2-yl}acetate
CAS 1008955-21-2C16H21N3O3S
Ethyl [3-oxo-1-(phenylcarbamothioyl)piperazin-2-yl]acetate chemical structure, C15H19N3O3S, CAS 126462-91-7
Ethyl [3-oxo-1-(phenylcarbamothioyl)piperazin-2-yl]acetate
CAS 126462-91-7C15H19N3O3S
2-Pyrazineacetic acid, hexahydro-1-[[(3-methoxyphenyl)amino]carbonothioyl]-3-oxo-, ethyl ester chemical structure, C16H21N3O4S, CAS 1009243-94-0
2-Pyrazineacetic acid, hexahydro-1-[[(3-methoxyphenyl)amino]carbonothioyl]-3-oxo-, ethyl ester
CAS 1009243-94-0C16H21N3O4S
2-Pyrazineacetic acid, 1-[[(4-fluorophenyl)amino]carbonothioyl]hexahydro-3-oxo-, methyl ester chemical structure, C14H16FN3O3S, CAS 1008958-22-2
2-Pyrazineacetic acid, 1-[[(4-fluorophenyl)amino]carbonothioyl]hexahydro-3-oxo-, methyl ester
CAS 1008958-22-2C14H16FN3O3S
Methyl 2-{3-oxo-1-[(phenylamino)thioxomethyl]piperazin-2-yl}acetate chemical structure, C14H17N3O3S, CAS 1008482-51-6
Methyl 2-{3-oxo-1-[(phenylamino)thioxomethyl]piperazin-2-yl}acetate
CAS 1008482-51-6C14H17N3O3S