Murcko scaffold
Ring system with 4 rings and 21 atoms
79 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 21
- Chemicals
- 79
- With full pages
- 13
Scaffold SMILES
c1ccc(C(c2cn3ncnc3s2)N2CCOCC2)cc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 79 chemicals
![5-[(2,6-Dimethylmorpholin-4-yl)(3-fluorophenyl)methyl]-2-methyl[1,3]thiazolo[3,2-b][1,2,4]triazol-6-ol chemical structure, C18H21FN4O2S, CAS 1005041-35-9](/s/IEVXCZBUXQZCHV-UHFFFAOYSA-N.svg)
5-[(2,6-Dimethylmorpholin-4-yl)(3-fluorophenyl)methyl]-2-methyl[1,3]thiazolo[3,2-b][1,2,4]triazol-6-ol
CAS 1005041-35-9C18H21FN4O2S
![5-((3-Fluorophenyl)(morpholino)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol chemical structure, C16H17FN4O2S, CAS 851810-46-3](/s/VROTYVZQCVRDAO-UHFFFAOYSA-N.svg)
5-((3-Fluorophenyl)(morpholino)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol
CAS 851810-46-3C16H17FN4O2S
![5-((2,6-Dimethylmorpholino)(p-tolyl)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol chemical structure, C19H24N4O2S, CAS 1005083-09-9](/s/HQVRCELBSBOAGY-UHFFFAOYSA-N.svg)
5-((2,6-Dimethylmorpholino)(p-tolyl)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol
CAS 1005083-09-9C19H24N4O2S
![2-Methyl-5-(morpholino(p-tolyl)methyl)thiazolo[3,2-b][1,2,4]triazol-6-ol chemical structure, C17H20N4O2S, CAS 162661-15-6](/s/YVXIGEXCAZRXJC-UHFFFAOYSA-N.svg)
2-Methyl-5-(morpholino(p-tolyl)methyl)thiazolo[3,2-b][1,2,4]triazol-6-ol
CAS 162661-15-6C17H20N4O2S
![5-((4-Bromophenyl)(2,6-dimethylmorpholino)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol chemical structure, C18H21BrN4O2S, CAS 1005050-54-3](/s/KBVFGQXDEVQCEJ-UHFFFAOYSA-N.svg)
5-((4-Bromophenyl)(2,6-dimethylmorpholino)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol
CAS 1005050-54-3C18H21BrN4O2S
![2-Methyl-5-(morpholino(phenyl)methyl)thiazolo[3,2-b][1,2,4]triazol-6-ol chemical structure, C16H18N4O2S, CAS 162661-11-2](/s/HDMZHANPUCUPNW-UHFFFAOYSA-N.svg)
2-Methyl-5-(morpholino(phenyl)methyl)thiazolo[3,2-b][1,2,4]triazol-6-ol
CAS 162661-11-2C16H18N4O2S
![5-((4-Chlorophenyl)(2,6-dimethylmorpholino)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol chemical structure, C18H21ClN4O2S, CAS 1005041-44-0](/s/OFBJGKJMVMTULR-UHFFFAOYSA-N.svg)
5-((4-Chlorophenyl)(2,6-dimethylmorpholino)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol
CAS 1005041-44-0C18H21ClN4O2S
![5-((4-Chlorophenyl)(morpholino)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol chemical structure, C16H17ClN4O2S, CAS 851809-47-7](/s/PWUZSMRXWXHJHZ-UHFFFAOYSA-N.svg)
5-((4-Chlorophenyl)(morpholino)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol
CAS 851809-47-7C16H17ClN4O2S
![5-((4-Fluorophenyl)(morpholino)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol chemical structure, C16H17FN4O2S, CAS 851810-73-6](/s/JUYMQFXZCQIXNK-UHFFFAOYSA-N.svg)
5-((4-Fluorophenyl)(morpholino)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol
CAS 851810-73-6C16H17FN4O2S
![5-((4-Isopropylphenyl)(morpholino)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol chemical structure, C19H24N4O2S, CAS 851810-07-6](/s/DVAQKGJJMDWPTC-UHFFFAOYSA-N.svg)
5-((4-Isopropylphenyl)(morpholino)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol
CAS 851810-07-6C19H24N4O2S
![5-((2,6-Dimethylmorpholino)(p-tolyl)methyl)thiazolo[3,2-b][1,2,4]triazol-6-ol chemical structure, C18H22N4O2S, CAS 1008936-56-8](/s/JIYOWBWYOHODME-UHFFFAOYSA-N.svg)
5-((2,6-Dimethylmorpholino)(p-tolyl)methyl)thiazolo[3,2-b][1,2,4]triazol-6-ol
CAS 1008936-56-8C18H22N4O2S
![5-(Morpholino(p-tolyl)methyl)thiazolo[3,2-b][1,2,4]triazol-6-ol chemical structure, C16H18N4O2S, CAS 868219-46-9](/s/FFBIAJHSUPXVSC-UHFFFAOYSA-N.svg)
5-(Morpholino(p-tolyl)methyl)thiazolo[3,2-b][1,2,4]triazol-6-ol
CAS 868219-46-9C16H18N4O2S
![5-((3-Methoxyphenyl)(morpholino)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol chemical structure, C17H20N4O3S, CAS 851969-60-3](/s/JHVYKKQAAJZRIN-UHFFFAOYSA-N.svg)
5-((3-Methoxyphenyl)(morpholino)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol
CAS 851969-60-3C17H20N4O3S
![5-((4-Bromophenyl)(morpholino)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol chemical structure, C16H17BrN4O2S, CAS 851809-67-1](/s/ZVMOTOQRFGHSEH-UHFFFAOYSA-N.svg)
5-((4-Bromophenyl)(morpholino)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol
CAS 851809-67-1C16H17BrN4O2S
![5-((3-Chlorophenyl)(morpholino)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol chemical structure, C16H17ClN4O2S, CAS 851969-38-5](/s/JAELKPWETXHFKH-UHFFFAOYSA-N.svg)
5-((3-Chlorophenyl)(morpholino)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol
CAS 851969-38-5C16H17ClN4O2S
![2-Methyl-5-(morpholino(3,4,5-trimethoxyphenyl)methyl)thiazolo[3,2-b][1,2,4]triazol-6-ol chemical structure, C19H24N4O5S, CAS 851969-80-7](/s/SZPGIAZIAUGXKD-UHFFFAOYSA-N.svg)
2-Methyl-5-(morpholino(3,4,5-trimethoxyphenyl)methyl)thiazolo[3,2-b][1,2,4]triazol-6-ol
CAS 851969-80-7C19H24N4O5S
![5-((2,6-Dimethylmorpholino)(3,4,5-trimethoxyphenyl)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol chemical structure, C21H28N4O5S, CAS 1005072-28-5](/s/ZIQQCEIFLOXHFL-UHFFFAOYSA-N.svg)
5-((2,6-Dimethylmorpholino)(3,4,5-trimethoxyphenyl)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol
CAS 1005072-28-5C21H28N4O5S
![5-((2,6-Dimethylmorpholino)(4-methoxyphenyl)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol chemical structure, C19H24N4O3S, CAS 1008069-60-0](/s/IGYFOWGPMVMYAL-UHFFFAOYSA-N.svg)
5-((2,6-Dimethylmorpholino)(4-methoxyphenyl)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol
CAS 1008069-60-0C19H24N4O3S
![5-((4-Methoxyphenyl)(morpholino)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol chemical structure, C17H20N4O3S, CAS 162661-19-0](/s/ZQQHSYIFSRVFPE-UHFFFAOYSA-N.svg)
5-((4-Methoxyphenyl)(morpholino)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol
CAS 162661-19-0C17H20N4O3S
![5-((2,6-Dimethylmorpholino)(4-isopropylphenyl)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol chemical structure, C21H28N4O2S, CAS 1005079-15-1](/s/MDPYDADVMBZYRK-UHFFFAOYSA-N.svg)
5-((2,6-Dimethylmorpholino)(4-isopropylphenyl)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol
CAS 1005079-15-1C21H28N4O2S
![5-((3,4-Dimethoxyphenyl)(2,6-dimethylmorpholino)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol chemical structure, C20H26N4O4S, CAS 1005072-46-7](/s/HPWZRYPYZLSORA-UHFFFAOYSA-N.svg)
5-((3,4-Dimethoxyphenyl)(2,6-dimethylmorpholino)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol
CAS 1005072-46-7C20H26N4O4S
![5-((2,6-Dimethylmorpholino)(4-fluorophenyl)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol chemical structure, C18H21FN4O2S, CAS 1008248-04-1](/s/ZONACRCSPZISRT-UHFFFAOYSA-N.svg)
5-((2,6-Dimethylmorpholino)(4-fluorophenyl)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol
CAS 1008248-04-1C18H21FN4O2S
![2-Methyl-5-(morpholino(4-nitrophenyl)methyl)thiazolo[3,2-b][1,2,4]triazol-6-ol chemical structure, C16H17N5O4S, CAS 851969-15-8](/s/DFLRKFCCKNZGJP-UHFFFAOYSA-N.svg)
2-Methyl-5-(morpholino(4-nitrophenyl)methyl)thiazolo[3,2-b][1,2,4]triazol-6-ol
CAS 851969-15-8C16H17N5O4S
![5-((2,6-Dimethylmorpholino)(3-fluorophenyl)methyl)thiazolo[3,2-b][1,2,4]triazol-6-ol chemical structure, C17H19FN4O2S, CAS 1009742-53-3](/s/VCWKKHRFLOLDAF-UHFFFAOYSA-N.svg)
5-((2,6-Dimethylmorpholino)(3-fluorophenyl)methyl)thiazolo[3,2-b][1,2,4]triazol-6-ol
CAS 1009742-53-3C17H19FN4O2S
- 5-((2,6-Dimethylmorpholino)(4-nitrophenyl)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol1008069-88-2C18H21N5O4S
- 5-((2,6-Dimethylmorpholino)(3-methoxyphenyl)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol1008665-39-1C19H24N4O3S
- 5-((3-Methoxyphenyl)(morpholino)methyl)thiazolo[3,2-b][1,2,4]triazol-6-ol868220-41-1C16H18N4O3S
- 5-((2,6-Dimethylmorpholino)(4-methoxyphenyl)methyl)thiazolo[3,2-b][1,2,4]triazol-6-ol1008946-49-3C18H22N4O3S
- 5-((3-Chlorophenyl)(2,6-dimethylmorpholino)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol1008248-39-2C18H21ClN4O2S
- 5-((3,4-Dimethoxyphenyl)(morpholino)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol851809-88-6C18H22N4O4S
- 5-((3,4-Dimethoxyphenyl)(2,6-dimethylmorpholino)methyl)thiazolo[3,2-b][1,2,4]triazol-6-ol1005259-07-3C19H24N4O4S
- 5-((4-Fluorophenyl)(morpholino)methyl)thiazolo[3,2-b][1,2,4]triazol-6-ol868220-18-2C15H15FN4O2S
- 5-((2,6-Dimethylmorpholino)(4-fluorophenyl)methyl)thiazolo[3,2-b][1,2,4]triazol-6-ol1009227-35-3C17H19FN4O2S
- 5-[(3-Bromophenyl)(morpholin-4-yl)methyl]-2-methyl-[1,2,4]triazolo[3,2-b][1,3]thiazol-6-ol869343-32-8C16H17BrN4O2S
- 5-((2-Fluorophenyl)(morpholino)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol869343-33-9C16H17FN4O2S
- 2-Methyl-5-[(3-methylphenyl)(morpholin-4-yl)methyl]-[1,2,4]triazolo[3,2-b][1,3]thiazol-6-ol869343-34-0C17H20N4O2S
- 5-((4-Ethoxyphenyl)(morpholino)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol869343-35-1C18H22N4O3S
- 5-((2-Chlorophenyl)(morpholino)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol869343-36-2C16H17ClN4O2S
- 5-((3,4-Dichlorophenyl)(morpholino)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol869343-37-3C16H16Cl2N4O2S
- 5-((3,4-Difluorophenyl)(morpholino)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol869343-38-4C16H16F2N4O2S
- 5-((4-Ethoxy-3-methoxyphenyl)(morpholino)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol869343-39-5C19H24N4O4S
- 5-((3-Bromophenyl)(2,6-dimethylmorpholino)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol1052554-99-0C18H21BrN4O2S
- 5-((2,6-Dimethylmorpholino)(2-fluorophenyl)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol1008213-56-6C18H21FN4O2S
- 5-((2,6-Dimethylmorpholino)(m-tolyl)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol1008267-11-5C19H24N4O2S
- 5-((2,6-Dimethylmorpholino)(4-ethoxyphenyl)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol1008019-25-7C20H26N4O3S
- 5-((2-Chlorophenyl)(2,6-dimethylmorpholino)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol1009230-55-0C18H21ClN4O2S
- 5-((3,4-Dichlorophenyl)(2,6-dimethylmorpholino)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol1052554-25-2C18H20Cl2N4O2S
- 5-((3,4-Difluorophenyl)(2,6-dimethylmorpholino)methyl)-2-methylthiazolo[3,2-b][1,2,4]triazol-6-ol1008068-97-0C18H20F2N4O2S
Related scaffolds
Same ring framework with different atoms or bond orders
