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Murcko scaffold

Ring system with 3 rings and 22 atoms

20 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 22
Chemicals: 20
With full pages: 7

Scaffold SMILES

O=C(NCCc1ccccc1)c1conc1-c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(NCCc1ccccc1)c1conc1-c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 20 of 20 chemicals

3-(2-Chlorophenyl)-5-methyl-N-(1-phenylpropan-2-yl)-1,2-oxazole-4-carboxamide chemical structure, C20H19ClN2O2, CAS 385387-41-7

3-(2-Chlorophenyl)-5-methyl-N-(1-phenylpropan-2-yl)-1,2-oxazole-4-carboxamide

CAS 385387-41-7C₂₀H₁₉ClN₂O₂

3-(2-Chlorophenyl)-5-methyl-N-(2-phenylethyl)-1,2-oxazole-4-carboxamide chemical structure, C19H17ClN2O2, CAS 303134-66-9

3-(2-Chlorophenyl)-5-methyl-N-(2-phenylethyl)-1,2-oxazole-4-carboxamide

CAS 303134-66-9C₁₉H₁₇ClN₂O₂

5-Methyl-3-phenyl-N-(2-phenylethyl)-1,2-oxazole-4-carboxamide chemical structure, C19H18N2O2, CAS 420844-84-4

5-Methyl-3-phenyl-N-(2-phenylethyl)-1,2-oxazole-4-carboxamide

CAS 420844-84-4C₁₉H₁₈N₂O₂

N-[2-(4-Fluorophenyl)ethyl]-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide chemical structure, C19H17FN2O2, CAS 420844-78-6

N-[2-(4-Fluorophenyl)ethyl]-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide

CAS 420844-78-6C₁₉H₁₇FN₂O₂

N-[2-(3-Chlorophenyl)ethyl]-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide chemical structure, C19H17ClN2O2, CAS 313069-10-2

N-[2-(3-Chlorophenyl)ethyl]-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide

CAS 313069-10-2C₁₉H₁₇ClN₂O₂

3-(2-Chloro-6-fluorophenyl)-N-[2-(4-chlorophenyl)ethyl]-5-methyl-1,2-oxazole-4-carboxamide chemical structure, C19H15Cl2FN2O2, CAS 492434-46-5

3-(2-Chloro-6-fluorophenyl)-N-[2-(4-chlorophenyl)ethyl]-5-methyl-1,2-oxazole-4-carboxamide

CAS 492434-46-5C₁₉H₁₅Cl₂FN₂O₂

3-(2,6-Dichlorophenyl)-5-methyl-N-(2-phenylethyl)isoxazole-4-carboxamide chemical structure, C19H16Cl2N2O2, CAS 346698-75-7

3-(2,6-Dichlorophenyl)-5-methyl-N-(2-phenylethyl)isoxazole-4-carboxamide

CAS 346698-75-7C₁₉H₁₆Cl₂N₂O₂

3-(2-Chloro-6-fluorophenyl)-5-methyl-N-phenethylisoxazole-4-carboxamide chemical structure, C19H16ClFN2O2, CAS 288317-54-4

3-(2-Chloro-6-fluorophenyl)-5-methyl-N-phenethylisoxazole-4-carboxamide

CAS 288317-54-4C₁₉H₁₆ClFN₂O₂

3-(2-Chlorophenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-5-methyl-1,2-oxazole-4-carboxamide chemical structure, C21H21ClN2O4, CAS 217317-62-9

3-(2-Chlorophenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-5-methyl-1,2-oxazole-4-carboxamide

CAS 217317-62-9C₂₁H₂₁ClN₂O₄

3-(2-Chloro-6-fluorophenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-5-methyl-1,2-oxazole-4-carboxamide chemical structure, C21H20ClFN2O4, CAS 442669-17-2

3-(2-Chloro-6-fluorophenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-5-methyl-1,2-oxazole-4-carboxamide

CAS 442669-17-2C₂₁H₂₀ClFN₂O₄

3-(2-Chlorophenyl)-N-[2-(4-methoxyphenyl)ethyl]-5-methyl-1,2-oxazole-4-carboxamide chemical structure, C20H19ClN2O3, CAS 5701-84-8

3-(2-Chlorophenyl)-N-[2-(4-methoxyphenyl)ethyl]-5-methyl-1,2-oxazole-4-carboxamide

CAS 5701-84-8C₂₀H₁₉ClN₂O₃

N-[2-(3,4-Dimethoxyphenyl)ethyl]-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide chemical structure, C21H22N2O4, CAS 217317-64-1

N-[2-(3,4-Dimethoxyphenyl)ethyl]-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide

CAS 217317-64-1C₂₁H₂₂N₂O₄

3-(2-Chloro-6-fluorophenyl)-5-methyl-N-[2-(4-sulfamoylphenyl)ethyl]-1,2-oxazole-4-carboxamide chemical structure, C19H17ClFN3O4S, CAS 774587-64-3

3-(2-Chloro-6-fluorophenyl)-5-methyl-N-[2-(4-sulfamoylphenyl)ethyl]-1,2-oxazole-4-carboxamide

CAS 774587-64-3C₁₉H₁₇ClFN₃O₄S

3-(2-Chlorophenyl)-N-[2-(3-chlorophenyl)ethyl]-5-methyl-1,2-oxazole-4-carboxamide chemical structure, C19H16Cl2N2O2, CAS 352682-32-7

3-(2-Chlorophenyl)-N-[2-(3-chlorophenyl)ethyl]-5-methyl-1,2-oxazole-4-carboxamide

CAS 352682-32-7C₁₉H₁₆Cl₂N₂O₂

3-(2,6-Dichlorophenyl)-N-[2-(4-fluorophenyl)ethyl]-5-methyl-1,2-oxazole-4-carboxamide chemical structure, C19H15Cl2FN2O2, CAS 442564-98-9

3-(2,6-Dichlorophenyl)-N-[2-(4-fluorophenyl)ethyl]-5-methyl-1,2-oxazole-4-carboxamide

CAS 442564-98-9C₁₉H₁₅Cl₂FN₂O₂

3-(2,6-Dichlorophenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-5-methyl-1,2-oxazole-4-carboxamide chemical structure, C21H20Cl2N2O4, CAS 217317-66-3

3-(2,6-Dichlorophenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-5-methyl-1,2-oxazole-4-carboxamide

CAS 217317-66-3C₂₁H₂₀Cl₂N₂O₄

3-(2,6-Dichlorophenyl)-5-methyl-N-[2-(4-sulfamoylphenyl)ethyl]-1,2-oxazole-4-carboxamide chemical structure, C19H17Cl2N3O4S, CAS 24477-34-7

3-(2,6-Dichlorophenyl)-5-methyl-N-[2-(4-sulfamoylphenyl)ethyl]-1,2-oxazole-4-carboxamide

CAS 24477-34-7C₁₉H₁₇Cl₂N₃O₄S

3-(2-Chlorophenyl)-N-(4-(dimethylamino)phenethyl)-5-methylisoxazole-4-carboxamide chemical structure, C21H22ClN3O2, CAS 953169-80-7

3-(2-Chlorophenyl)-N-(4-(dimethylamino)phenethyl)-5-methylisoxazole-4-carboxamide

CAS 953169-80-7C₂₁H₂₂ClN₃O₂

3-(2-Chlorophenyl)-5-methyl-N-(3,3,3-trifluoro-2-hydroxy-2-phenylpropyl)isoxazole-4-carboxamide chemical structure, C20H16ClF3N2O3, CAS 1351609-09-0

3-(2-Chlorophenyl)-5-methyl-N-(3,3,3-trifluoro-2-hydroxy-2-phenylpropyl)isoxazole-4-carboxamide

CAS 1351609-09-0C₂₀H₁₆ClF₃N₂O₃

3-(2-Chlorophenyl)-N-(2-hydroxy-2-(4-(methylthio)phenyl)ethyl)-5-methylisoxazole-4-carboxamide chemical structure, C20H19ClN2O3S, CAS 1448076-55-8

3-(2-Chlorophenyl)-N-(2-hydroxy-2-(4-(methylthio)phenyl)ethyl)-5-methylisoxazole-4-carboxamide

CAS 1448076-55-8C₂₀H₁₉ClN₂O₃S