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Murcko scaffold

Ring system with 3 rings and 22 atoms

24 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
24
With full pages
20
Scaffold SMILES

S=c1[nH]nc(-c2ccccc2)n1N=CC=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold S=c1[nH]nc(-c2ccccc2)n1N=CC=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 24 of 24 chemicals

5-(2,4-Dichlorophenyl)-2,4-dihydro-4-[[(2Z)-3-(2-methoxyphenyl)-2-propen-1-ylidene]amino]-3H-1,2,4-triazole-3-thione chemical structure, C18H14Cl2N4OS, CAS 1164560-55-7
5-(2,4-Dichlorophenyl)-2,4-dihydro-4-[[(2Z)-3-(2-methoxyphenyl)-2-propen-1-ylidene]amino]-3H-1,2,4-triazole-3-thione
CAS 1164560-55-7C18H14Cl2N4OS
4-((3-(2-Meo-PH)-2-propenylidene)amino)-5-(3-ME-PH)-4H-1,2,4-triazole-3-thiol chemical structure, C19H18N4OS, CAS 478256-17-6
4-((3-(2-Meo-PH)-2-propenylidene)amino)-5-(3-ME-PH)-4H-1,2,4-triazole-3-thiol
CAS 478256-17-6C19H18N4OS
3-(4-Methoxyphenyl)-4-[(E)-[(E)-2-methyl-3-phenylprop-2-enylidene]amino]-1H-1,2,4-triazole-5-thione chemical structure, C19H18N4OS, CAS 380457-99-8
3-(4-Methoxyphenyl)-4-[(E)-[(E)-2-methyl-3-phenylprop-2-enylidene]amino]-1H-1,2,4-triazole-5-thione
CAS 380457-99-8C19H18N4OS
3-(2-Methylphenyl)-4-[(E)-[(E)-3-phenylprop-2-enylidene]amino]-1H-1,2,4-triazole-5-thione chemical structure, C18H16N4S, CAS 487032-11-1
3-(2-Methylphenyl)-4-[(E)-[(E)-3-phenylprop-2-enylidene]amino]-1H-1,2,4-triazole-5-thione
CAS 487032-11-1C18H16N4S
4-[(E)-[(Z)-2-Chloro-3-phenylprop-2-enylidene]amino]-3-(3,4-dimethoxyphenyl)-1H-1,2,4-triazole-5-thione chemical structure, C19H17ClN4O2S, CAS 488094-67-3
4-[(E)-[(Z)-2-Chloro-3-phenylprop-2-enylidene]amino]-3-(3,4-dimethoxyphenyl)-1H-1,2,4-triazole-5-thione
CAS 488094-67-3C19H17ClN4O2S
3-(4-Chlorophenyl)-4-[(E)-[(E)-3-(2-methoxyphenyl)prop-2-enylidene]amino]-1H-1,2,4-triazole-5-thione chemical structure, C18H15ClN4OS, CAS 380457-89-6
3-(4-Chlorophenyl)-4-[(E)-[(E)-3-(2-methoxyphenyl)prop-2-enylidene]amino]-1H-1,2,4-triazole-5-thione
CAS 380457-89-6C18H15ClN4OS
3-(4-Fluorophenyl)-4-[(E)-[(E)-3-(2-methoxyphenyl)prop-2-enylidene]amino]-1H-1,2,4-triazole-5-thione chemical structure, C18H15FN4OS, CAS 573932-40-8
3-(4-Fluorophenyl)-4-[(E)-[(E)-3-(2-methoxyphenyl)prop-2-enylidene]amino]-1H-1,2,4-triazole-5-thione
CAS 573932-40-8C18H15FN4OS
4-((2-CL-3-PH-2-Propenylidene)amino)-5-(2-meo-phenyl)-4H-1,2,4-triazole-3-thiol chemical structure, C18H15ClN4OS, CAS 497920-22-6
4-((2-CL-3-PH-2-Propenylidene)amino)-5-(2-meo-phenyl)-4H-1,2,4-triazole-3-thiol
CAS 497920-22-6C18H15ClN4OS
5-(3-Methyl-PH)-4-((2-ME-3-PH-2-propenylidene)amino)-4H-1,2,4-triazole-3-thiol chemical structure, C19H18N4S, CAS 478255-99-1
5-(3-Methyl-PH)-4-((2-ME-3-PH-2-propenylidene)amino)-4H-1,2,4-triazole-3-thiol
CAS 478255-99-1C19H18N4S
5-(3-Methylphenyl)-4-((3-phenyl-2-propenylidene)amino)-4H-1,2,4-triazole-3-thiol chemical structure, C18H16N4S, CAS 478256-13-2
5-(3-Methylphenyl)-4-((3-phenyl-2-propenylidene)amino)-4H-1,2,4-triazole-3-thiol
CAS 478256-13-2C18H16N4S
4-((2-CL-3-PH-2-Propenylidene)amino)-5-(3-methyl-PH)-4H-1,2,4-triazole-3-thiol chemical structure, C18H15ClN4S, CAS 478255-88-8
4-((2-CL-3-PH-2-Propenylidene)amino)-5-(3-methyl-PH)-4H-1,2,4-triazole-3-thiol
CAS 478255-88-8C18H15ClN4S
5-(3-CL-Phenyl)-4-((2-ME-3-PH-2-propenylidene)amino)-4H-1,2,4-triazole-3-thiol chemical structure, C18H15ClN4S, CAS 478255-05-9
5-(3-CL-Phenyl)-4-((2-ME-3-PH-2-propenylidene)amino)-4H-1,2,4-triazole-3-thiol
CAS 478255-05-9C18H15ClN4S
5-(3-CL-Phenyl)-4-((2-CL-3-PH-2-propenylidene)amino)-4H-1,2,4-triazole-3-thiol chemical structure, C17H12Cl2N4S, CAS 478254-94-3
5-(3-CL-Phenyl)-4-((2-CL-3-PH-2-propenylidene)amino)-4H-1,2,4-triazole-3-thiol
CAS 478254-94-3C17H12Cl2N4S
5-(3-ME-PH)-4-((3-(2-Nitro-PH)-2-propenylidene)amino)-4H-1,2,4-triazole-3-thiol chemical structure, C18H15N5O2S, CAS 478256-33-6
5-(3-ME-PH)-4-((3-(2-Nitro-PH)-2-propenylidene)amino)-4H-1,2,4-triazole-3-thiol
CAS 478256-33-6C18H15N5O2S
5-(3-Chlorophenyl)-4-((3-phenyl-2-propenylidene)amino)-4H-1,2,4-triazole-3-thiol chemical structure, C17H13ClN4S, CAS 478255-19-5
5-(3-Chlorophenyl)-4-((3-phenyl-2-propenylidene)amino)-4H-1,2,4-triazole-3-thiol
CAS 478255-19-5C17H13ClN4S
5-(3-Chlorophenyl)-4-{[(E,2E)-3-(2-methoxyphenyl)-2-propenylidene]amino}-4H-1,2,4-triazol-3-yl hydrosulfide chemical structure, C18H15ClN4OS, CAS 478255-22-0
5-(3-Chlorophenyl)-4-{[(E,2E)-3-(2-methoxyphenyl)-2-propenylidene]amino}-4H-1,2,4-triazol-3-yl hydrosulfide
CAS 478255-22-0C18H15ClN4OS
5-(3-CL-PH)-4-((3-(2-Nitro-PH)-2-propenylidene)amino)-4H-1,2,4-triazole-3-thiol chemical structure, C17H12ClN5O2S, CAS 478255-36-6
5-(3-CL-PH)-4-((3-(2-Nitro-PH)-2-propenylidene)amino)-4H-1,2,4-triazole-3-thiol
CAS 478255-36-6C17H12ClN5O2S
3-(2-Fluorophenyl)-4-[(E)-[(E)-3-(2-nitrophenyl)prop-2-enylidene]amino]-1H-1,2,4-triazole-5-thione chemical structure, C17H12FN5O2S, CAS 676624-78-5
3-(2-Fluorophenyl)-4-[(E)-[(E)-3-(2-nitrophenyl)prop-2-enylidene]amino]-1H-1,2,4-triazole-5-thione
CAS 676624-78-5C17H12FN5O2S
4-((2-CL-3-PH-2-Propenylidene)amino)-5-(4-F-PH)-4H-1,2,4-triazole-3-thiol chemical structure, C17H12ClFN4S, CAS 674813-21-9
4-((2-CL-3-PH-2-Propenylidene)amino)-5-(4-F-PH)-4H-1,2,4-triazole-3-thiol
CAS 674813-21-9C17H12ClFN4S
5-(2-F-PH)-4-((3-(2-Meo-phenyl)-2-propenylidene)amino)-4H-1,2,4-triazole-3-thiol chemical structure, C18H15FN4OS, CAS 677305-82-7
5-(2-F-PH)-4-((3-(2-Meo-phenyl)-2-propenylidene)amino)-4H-1,2,4-triazole-3-thiol
CAS 677305-82-7C18H15FN4OS
4-((2-CL-3-PH-2-Propenylidene)amino)-5-(2-F-phenyl)-4H-1,2,4-triazole-3-thiol chemical structure, C17H12ClFN4S, CAS 587008-49-9
4-((2-CL-3-PH-2-Propenylidene)amino)-5-(2-F-phenyl)-4H-1,2,4-triazole-3-thiol
CAS 587008-49-9C17H12ClFN4S
5-(2-CL-Phenyl)-4-((2-CL-3-PH-2-propenylidene)amino)-4H-1,2,4-triazole-3-thiol chemical structure, C17H12Cl2N4S, CAS 478254-13-6
5-(2-CL-Phenyl)-4-((2-CL-3-PH-2-propenylidene)amino)-4H-1,2,4-triazole-3-thiol
CAS 478254-13-6C17H12Cl2N4S
5-(2-CL-Phenyl)-4-((2-ME-3-PH-2-propenylidene)amino)-4H-1,2,4-triazole-3-thiol chemical structure, C18H15ClN4S, CAS 478254-20-5
5-(2-CL-Phenyl)-4-((2-ME-3-PH-2-propenylidene)amino)-4H-1,2,4-triazole-3-thiol
CAS 478254-20-5C18H15ClN4S
5-(2-Meo-phenyl)-4-((2-ME-3-PH-2-propenylidene)amino)-4H-1,2,4-triazole-3-thiol chemical structure, C19H18N4OS, CAS 478256-94-9
5-(2-Meo-phenyl)-4-((2-ME-3-PH-2-propenylidene)amino)-4H-1,2,4-triazole-3-thiol
CAS 478256-94-9C19H18N4OS