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Murcko scaffold

Ring system with 6 rings and 26 atoms

27 chemicals on CompoundList share this ring system.

Rings
6
Scaffold atoms
26
Chemicals
27
With full pages
4
Scaffold SMILES

O=C(NN=Cc1ccccc1)c1cc(C23CC4CC(CC(C4)C2)C3)[nH]n1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NN=Cc1ccccc1)c1cc(C23CC4CC(CC(C4)C2)C3)[nH]n1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 27 of 27 chemicals

3-(Adamantan-1-yl)-N'-(1-(4-chlorophenyl)ethylidene)-1H-pyrazole-5-carbohydrazide chemical structure, C22H25ClN4O, CAS 955874-39-2
3-(Adamantan-1-yl)-N'-(1-(4-chlorophenyl)ethylidene)-1H-pyrazole-5-carbohydrazide
CAS 955874-39-2C22H25ClN4O
5-(1-Adamantyl)-N-[(E)-(4-bromophenyl)methylideneamino]-1H-pyrazole-3-carboxamide chemical structure, C21H23BrN4O, CAS 1284266-14-3
5-(1-Adamantyl)-N-[(E)-(4-bromophenyl)methylideneamino]-1H-pyrazole-3-carboxamide
CAS 1284266-14-3C21H23BrN4O
5-(1-Adamantyl)-N-[(E)-(4-chlorophenyl)methylideneamino]-1H-pyrazole-3-carboxamide chemical structure, C21H23ClN4O, CAS 307320-61-2
5-(1-Adamantyl)-N-[(E)-(4-chlorophenyl)methylideneamino]-1H-pyrazole-3-carboxamide
CAS 307320-61-2C21H23ClN4O
5-(1-Adamantyl)-N-[(E)-[4-(diethylamino)phenyl]methylideneamino]-1H-pyrazole-3-carboxamide chemical structure, C25H33N5O, CAS 5785-87-5
5-(1-Adamantyl)-N-[(E)-[4-(diethylamino)phenyl]methylideneamino]-1H-pyrazole-3-carboxamide
CAS 5785-87-5C25H33N5O
5-(1-Adamantyl)-N-[(E)-(2-methoxyphenyl)methylideneamino]-1H-pyrazole-3-carboxamide chemical structure, C22H26N4O2, CAS 1285496-19-6
5-(1-Adamantyl)-N-[(E)-(2-methoxyphenyl)methylideneamino]-1H-pyrazole-3-carboxamide
CAS 1285496-19-6C22H26N4O2
5-(1-Adamantyl)-N-[(E)-benzylideneamino]-1H-pyrazole-3-carboxamide chemical structure, C21H24N4O, CAS 1285599-77-0
5-(1-Adamantyl)-N-[(E)-benzylideneamino]-1H-pyrazole-3-carboxamide
CAS 1285599-77-0C21H24N4O
5-(1-Adamantyl)-N-[(E)-(4-ethoxyphenyl)methylideneamino]-1H-pyrazole-3-carboxamide chemical structure, C23H28N4O2, CAS 1299483-95-6
5-(1-Adamantyl)-N-[(E)-(4-ethoxyphenyl)methylideneamino]-1H-pyrazole-3-carboxamide
CAS 1299483-95-6C23H28N4O2
5-(1-Adamantyl)-N-[(E)-(4-nitrophenyl)methylideneamino]-1H-pyrazole-3-carboxamide chemical structure, C21H23N5O3, CAS 5789-01-5
5-(1-Adamantyl)-N-[(E)-(4-nitrophenyl)methylideneamino]-1H-pyrazole-3-carboxamide
CAS 5789-01-5C21H23N5O3
5-(1-Adamantyl)-N-[(E)-(2,4-dichlorophenyl)methylideneamino]-1H-pyrazole-3-carboxamide chemical structure, C21H22Cl2N4O, CAS 1285641-72-6
5-(1-Adamantyl)-N-[(E)-(2,4-dichlorophenyl)methylideneamino]-1H-pyrazole-3-carboxamide
CAS 1285641-72-6C21H22Cl2N4O
5-(1-Adamantyl)-N-[(E)-(4-fluorophenyl)methylideneamino]-1H-pyrazole-3-carboxamide chemical structure, C21H23FN4O, CAS 1285650-36-3
5-(1-Adamantyl)-N-[(E)-(4-fluorophenyl)methylideneamino]-1H-pyrazole-3-carboxamide
CAS 1285650-36-3C21H23FN4O
5-(1-Adamantyl)-N-[(E)-1-(4-ethoxyphenyl)ethylideneamino]-1H-pyrazole-3-carboxamide chemical structure, C24H30N4O2, CAS 1285532-36-6
5-(1-Adamantyl)-N-[(E)-1-(4-ethoxyphenyl)ethylideneamino]-1H-pyrazole-3-carboxamide
CAS 1285532-36-6C24H30N4O2
3-(1-Adamantyl)-N'-{(E)-[4-(dimethylamino)phenyl]methylidene}-1H-pyrazole-5-carbohydrazide chemical structure, C23H29N5O, CAS 1285541-76-5
3-(1-Adamantyl)-N'-{(E)-[4-(dimethylamino)phenyl]methylidene}-1H-pyrazole-5-carbohydrazide
CAS 1285541-76-5C23H29N5O
5-(1-Adamantyl)-N-[(Z)-1-(4-bromophenyl)ethylideneamino]-1H-pyrazole-3-carboxamide chemical structure, C22H25BrN4O, CAS 307321-40-0
5-(1-Adamantyl)-N-[(Z)-1-(4-bromophenyl)ethylideneamino]-1H-pyrazole-3-carboxamide
CAS 307321-40-0C22H25BrN4O
5-(1-Adamantyl)-N-[(E)-(4-methoxyphenyl)methylideneamino]-1H-pyrazole-3-carboxamide chemical structure, C22H26N4O2, CAS 305355-95-7
5-(1-Adamantyl)-N-[(E)-(4-methoxyphenyl)methylideneamino]-1H-pyrazole-3-carboxamide
CAS 305355-95-7C22H26N4O2
5-(1-Adamantyl)-N-[(E)-(4-methylphenyl)methylideneamino]-1H-pyrazole-3-carboxamide chemical structure, C22H26N4O, CAS 307320-58-7
5-(1-Adamantyl)-N-[(E)-(4-methylphenyl)methylideneamino]-1H-pyrazole-3-carboxamide
CAS 307320-58-7C22H26N4O
5-(1-Adamantyl)-N-[(E)-1-(4-chlorophenyl)ethylideneamino]-1H-pyrazole-3-carboxamide chemical structure, C22H25ClN4O, CAS 1285560-19-1
5-(1-Adamantyl)-N-[(E)-1-(4-chlorophenyl)ethylideneamino]-1H-pyrazole-3-carboxamide
CAS 1285560-19-1C22H25ClN4O
4-((5-Adamantan-1-YL-2H-pyrazole-3-carbonyl)-hydrazono-ME)-benzoic acid ME ester chemical structure, C23H26N4O3, CAS 307320-69-0
4-((5-Adamantan-1-YL-2H-pyrazole-3-carbonyl)-hydrazono-ME)-benzoic acid ME ester
CAS 307320-69-0C23H26N4O3
(E)-3-((1s,3s)-Adamantan-1-yl)-N'-(3-nitrobenzylidene)-1H-pyrazole-5-carbohydrazide chemical structure, C21H23N5O3, CAS 305356-02-9
(E)-3-((1s,3s)-Adamantan-1-yl)-N'-(3-nitrobenzylidene)-1H-pyrazole-5-carbohydrazide
CAS 305356-02-9C21H23N5O3
(E)-3-((1s,3s)-Adamantan-1-yl)-N'-(4-isopropylbenzylidene)-1H-pyrazole-5-carbohydrazide chemical structure, C24H30N4O, CAS 307320-59-8
(E)-3-((1s,3s)-Adamantan-1-yl)-N'-(4-isopropylbenzylidene)-1H-pyrazole-5-carbohydrazide
CAS 307320-59-8C24H30N4O
(E)-3-((1S,3s)-Adamantan-1-yl)-N'-(2-chlorobenzylidene)-1H-pyrazole-5-carbohydrazide chemical structure, C21H23ClN4O, CAS 307320-57-6
(E)-3-((1S,3s)-Adamantan-1-yl)-N'-(2-chlorobenzylidene)-1H-pyrazole-5-carbohydrazide
CAS 307320-57-6C21H23ClN4O
(E)-3-((1s,3s)-Adamantan-1-yl)-N'-(5-bromo-2-hydroxybenzylidene)-1H-pyrazole-5-carbohydrazide chemical structure, C21H23BrN4O2, CAS 1285633-51-3
(E)-3-((1s,3s)-Adamantan-1-yl)-N'-(5-bromo-2-hydroxybenzylidene)-1H-pyrazole-5-carbohydrazide
CAS 1285633-51-3C21H23BrN4O2
(E)-3-((1s,3s)-Adamantan-1-yl)-N'-(3-allyl-2-hydroxybenzylidene)-1H-pyrazole-5-carbohydrazide chemical structure, C24H28N4O2, CAS 305356-10-9
(E)-3-((1s,3s)-Adamantan-1-yl)-N'-(3-allyl-2-hydroxybenzylidene)-1H-pyrazole-5-carbohydrazide
CAS 305356-10-9C24H28N4O2
(E)-3-((3r,5r,7r)-Adamantan-1-yl)-N'-(3,5-dibromo-2-hydroxybenzylidene)-1H-pyrazole-5-carbohydrazide chemical structure, C21H22Br2N4O2, CAS 305356-08-5
(E)-3-((3r,5r,7r)-Adamantan-1-yl)-N'-(3,5-dibromo-2-hydroxybenzylidene)-1H-pyrazole-5-carbohydrazide
CAS 305356-08-5C21H22Br2N4O2
3-(1-Adamantyl)-N'-(4-hydroxy-3-methoxybenzylidene)-1H-pyrazole-5-carbohydrazide chemical structure, C22H26N4O3, CAS 305356-13-2
3-(1-Adamantyl)-N'-(4-hydroxy-3-methoxybenzylidene)-1H-pyrazole-5-carbohydrazide
CAS 305356-13-2C22H26N4O3