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Murcko scaffold

Ring system with 2 rings and 11 atoms

11 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
11
Chemicals
11
With full pages
3
Scaffold SMILES

O=c1ccc2c([nH]1)NCCC2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1ccc2c([nH]1)NCCC2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 11 of 11 chemicals

8-Methyl-2-oxo-1,5,6,7-tetrahydro-1,8-naphthyridine-3-carbonitrile chemical structure, C10H11N3O, CAS 64792-42-3
8-Methyl-2-oxo-1,5,6,7-tetrahydro-1,8-naphthyridine-3-carbonitrile
CAS 64792-42-3C10H11N3O
2-Hydroxy-5,6,7,8-tetrahydro-1,8-naphthyridine-4-carboxylic acid chemical structure, C9H10N2O3, CAS 2225136-95-6
2-Hydroxy-5,6,7,8-tetrahydro-1,8-naphthyridine-4-carboxylic acid
CAS 2225136-95-6C9H10N2O3
5,6,7,8-Tetrahydro-1,8-naphthyridine-2,4-diol chemical structure, C8H10N2O2, CAS 2225147-26-0
5,6,7,8-Tetrahydro-1,8-naphthyridine-2,4-diol
CAS 2225147-26-0C8H10N2O2
8-[(tert-Butoxy)carbonyl]-2-hydroxy-5,6,7,8-tetrahydro-1,8-naphthyridine-4-carboxylic acid chemical structure, C14H18N2O5, CAS 2413900-42-0
8-[(tert-Butoxy)carbonyl]-2-hydroxy-5,6,7,8-tetrahydro-1,8-naphthyridine-4-carboxylic acid
CAS 2413900-42-0C14H18N2O5
Methyl 2-hydroxy-5,6,7,8-tetrahydro-1,8-naphthyridine-4-carboxylate chemical structure, C10H12N2O3, CAS 2639448-95-4
Methyl 2-hydroxy-5,6,7,8-tetrahydro-1,8-naphthyridine-4-carboxylate
CAS 2639448-95-4C10H12N2O3
tert-Butyl 2-hydroxy-5,6,7,8-tetrahydro-1,8-naphthyridine-4-carboxylate chemical structure, C13H18N2O3, CAS 2639403-88-4
tert-Butyl 2-hydroxy-5,6,7,8-tetrahydro-1,8-naphthyridine-4-carboxylate
CAS 2639403-88-4C13H18N2O3
tert-Butyl 5,7-dihydroxy-1,2,3,4-tetrahydro-1,8-naphthyridine-1-carboxylate chemical structure, C13H18N2O4, CAS 2639463-45-7
tert-Butyl 5,7-dihydroxy-1,2,3,4-tetrahydro-1,8-naphthyridine-1-carboxylate
CAS 2639463-45-7C13H18N2O4
Ethyl 2-hydroxy-5,6,7,8-tetrahydro-1,8-naphthyridine-4-carboxylate chemical structure, C11H14N2O3, CAS 2639454-48-9
Ethyl 2-hydroxy-5,6,7,8-tetrahydro-1,8-naphthyridine-4-carboxylate
CAS 2639454-48-9C11H14N2O3
8-Acetyl-2-hydroxy-5,6,7,8-tetrahydro-1,8-naphthyridine-4-carboxylic acid chemical structure, C11H12N2O4, CAS 2680728-37-2
8-Acetyl-2-hydroxy-5,6,7,8-tetrahydro-1,8-naphthyridine-4-carboxylic acid
CAS 2680728-37-2C11H12N2O4
2-Hydroxy-8-[(prop-2-en-1-yloxy)carbonyl]-5,6,7,8-tetrahydro-1,8-naphthyridine-4-carboxylic acid chemical structure, C13H14N2O5, CAS 2680700-51-8
2-Hydroxy-8-[(prop-2-en-1-yloxy)carbonyl]-5,6,7,8-tetrahydro-1,8-naphthyridine-4-carboxylic acid
CAS 2680700-51-8C13H14N2O5
2-Hydroxy-8-(2,2,2-trifluoroacetyl)-5,6,7,8-tetrahydro-1,8-naphthyridine-4-carboxylic acid chemical structure, C11H9F3N2O4, CAS 2680789-79-9
2-Hydroxy-8-(2,2,2-trifluoroacetyl)-5,6,7,8-tetrahydro-1,8-naphthyridine-4-carboxylic acid
CAS 2680789-79-9C11H9F3N2O4