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Murcko scaffold

Ring system with 2 rings and 12 atoms

27 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
27
With full pages
3
Scaffold SMILES

c1ccc(Cc2cccs2)nc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(Cc2cccs2)nc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 27 of 27 chemicals

2-Chloro-1-(5-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl}-2-thienyl)-1-ethanone chemical structure, C13H8Cl2F3NOS, CAS 338411-65-7
2-Chloro-1-(5-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl}-2-thienyl)-1-ethanone
CAS 338411-65-7C13H8Cl2F3NOS
3-Chloro-2-(2-thienylmethyl)-5-(trifluoromethyl)pyridine chemical structure, C11H7ClF3NS, CAS 339010-51-4
3-Chloro-2-(2-thienylmethyl)-5-(trifluoromethyl)pyridine
CAS 339010-51-4C11H7ClF3NS
5-{[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]methyl}-N,N-diethyl-2-thiophenesulfonamide chemical structure, C15H16ClF3N2O2S2, CAS 344278-38-2
5-{[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]methyl}-N,N-diethyl-2-thiophenesulfonamide
CAS 344278-38-2C15H16ClF3N2O2S2
5-{[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]methyl}-2-thiophenesulfonamide chemical structure, C11H8ClF3N2O2S2, CAS 339029-65-1
5-{[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]methyl}-2-thiophenesulfonamide
CAS 339029-65-1C11H8ClF3N2O2S2
5-{[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]methyl}-2-thiophenesulfonohydrazide chemical structure, C11H9ClF3N3O2S2, CAS 306976-75-0
5-{[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]methyl}-2-thiophenesulfonohydrazide
CAS 306976-75-0C11H9ClF3N3O2S2
1-(5-{[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]methyl}-2-thienyl)-1-ethanone chemical structure, C13H9ClF3NOS, CAS 321432-63-7
1-(5-{[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]methyl}-2-thienyl)-1-ethanone
CAS 321432-63-7C13H9ClF3NOS
5-{[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]methyl}-2-thiophenecarboxamide chemical structure, C12H8ClF3N2OS, CAS 321432-70-6
5-{[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]methyl}-2-thiophenecarboxamide
CAS 321432-70-6C12H8ClF3N2OS
2-Picoline, alpha-(2-(dimethylamino)ethoxy)-alpha-methyl-alpha-(2-thienyl)-, hydrochloride chemical structure, C15H21ClN2OS, CAS 73771-09-2
2-Picoline, alpha-(2-(dimethylamino)ethoxy)-alpha-methyl-alpha-(2-thienyl)-, hydrochloride
CAS 73771-09-2C15H21ClN2OS
5-[[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]methyl]thiophene-2-sulfonyl chloride chemical structure, C11H6Cl2F3NO2S2, CAS 339010-78-5
5-[[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]methyl]thiophene-2-sulfonyl chloride
CAS 339010-78-5C11H6Cl2F3NO2S2
2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-2-(2-thienyl)acetamide chemical structure, C12H8ClF3N2OS, CAS 861211-80-5
2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-2-(2-thienyl)acetamide
CAS 861211-80-5C12H8ClF3N2OS
5-{[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]methyl}-2-thiophenecarbonitrile chemical structure, C12H6ClF3N2S, CAS 321430-92-6
5-{[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]methyl}-2-thiophenecarbonitrile
CAS 321430-92-6C12H6ClF3N2S
5-{[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]methyl}-2-thiophenesulfonic acid chemical structure, C11H7ClF3NO3S2, CAS 339010-79-6
5-{[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]methyl}-2-thiophenesulfonic acid
CAS 339010-79-6C11H7ClF3NO3S2
Ethyl 2-(5-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl}-2-thienyl)-2-oxoacetate chemical structure, C15H11ClF3NO3S, CAS 439097-51-5
Ethyl 2-(5-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl}-2-thienyl)-2-oxoacetate
CAS 439097-51-5C15H11ClF3NO3S
2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-2-(2-thienyl)acetonitrile chemical structure, C12H6ClF3N2S, CAS 338407-61-7
2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-2-(2-thienyl)acetonitrile
CAS 338407-61-7C12H6ClF3N2S
(NZ)-N-[1-[5-[[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl]thiophen-2-yl]ethylidene]hydroxylamine chemical structure, C13H10ClF3N2OS, CAS 321432-65-9
(NZ)-N-[1-[5-[[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl]thiophen-2-yl]ethylidene]hydroxylamine
CAS 321432-65-9C13H10ClF3N2OS
5-[1-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-2-(hydroxyimino)ethyl]-N,N-diethyl-2-thiophenesulfonamide chemical structure, C16H17ClF3N3O3S2, CAS 344278-55-3
5-[1-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-2-(hydroxyimino)ethyl]-N,N-diethyl-2-thiophenesulfonamide
CAS 344278-55-3C16H17ClF3N3O3S2
2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-2-(2-thienyl)acetaldehyde oxime chemical structure, C12H8ClF3N2OS, CAS 338770-64-2
2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-2-(2-thienyl)acetaldehyde oxime
CAS 338770-64-2C12H8ClF3N2OS
5-[1-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-2-(methoxyimino)ethyl]-N,N-diethyl-2-thiophenesulfonamide chemical structure, C17H19ClF3N3O3S2, CAS 344278-51-9
5-[1-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-2-(methoxyimino)ethyl]-N,N-diethyl-2-thiophenesulfonamide
CAS 344278-51-9C17H19ClF3N3O3S2
2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-2-(2-thienyl)acetaldehyde O-methyloxime chemical structure, C13H10ClF3N2OS, CAS 338770-60-8
2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-2-(2-thienyl)acetaldehyde O-methyloxime
CAS 338770-60-8C13H10ClF3N2OS
(Pyridin-2-yl)(thiophen-2-yl)methanamine chemical structure, C10H10N2S, CAS 58088-49-6
(Pyridin-2-yl)(thiophen-2-yl)methanamine
CAS 58088-49-6C10H10N2S
(Pyridin-2-yl)(thiophen-2-yl)acetonitrile chemical structure, C11H8N2S, CAS 24783-40-2
(Pyridin-2-yl)(thiophen-2-yl)acetonitrile
CAS 24783-40-2C11H8N2S
Pyridin-2-yl(thiophen-2-yl)methanol chemical structure, C10H9NOS, CAS 21327-69-5
Pyridin-2-yl(thiophen-2-yl)methanol
CAS 21327-69-5C10H9NOS
4,5-Dimethyl-2-[(thiophen-2-yl)methyl]pyridine chemical structure, C12H13NS, CAS 63152-41-0
4,5-Dimethyl-2-[(thiophen-2-yl)methyl]pyridine
CAS 63152-41-0C12H13NS
2-Amino-5-[(pyridin-2-yl)methyl]thiophene-3-carbonitrile chemical structure, C11H9N3S, CAS 1221432-10-5
2-Amino-5-[(pyridin-2-yl)methyl]thiophene-3-carbonitrile
CAS 1221432-10-5C11H9N3S