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Murcko scaffold

Ring system with 3 rings and 19 atoms

80 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
80
With full pages
4
Scaffold SMILES

O=C1NC(c2cccs2)C(=Cc2ccccc2)C1=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1NC(c2cccs2)C(=Cc2ccccc2)C1=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 80 chemicals

1-[2-(Diethylamino)ethyl]-3-hydroxy-4-(4-methoxy-3-methylbenzoyl)-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H28N2O4S
1-[2-(Diethylamino)ethyl]-3-hydroxy-4-(4-methoxy-3-methylbenzoyl)-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one
C23H28N2O4S
1-[3-(Dimethylamino)propyl]-3-hydroxy-4-[3-methyl-4-(propan-2-yloxy)benzoyl]-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H30N2O4S, CAS 510712-11-5
1-[3-(Dimethylamino)propyl]-3-hydroxy-4-[3-methyl-4-(propan-2-yloxy)benzoyl]-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one
CAS 510712-11-5C24H30N2O4S
1-[3-(Diethylamino)propyl]-3-hydroxy-4-(4-methylbenzoyl)-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H28N2O3S, CAS 608108-07-2
1-[3-(Diethylamino)propyl]-3-hydroxy-4-(4-methylbenzoyl)-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one
CAS 608108-07-2C23H28N2O3S
1-[3-(Dimethylamino)propyl]-4-(3-ethoxybenzoyl)-3-hydroxy-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C22H26N2O4S
1-[3-(Dimethylamino)propyl]-4-(3-ethoxybenzoyl)-3-hydroxy-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one
C22H26N2O4S
4-(3-Ethoxybenzoyl)-3-hydroxy-1-(2-methoxyethyl)-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C20H21NO5S, CAS 608500-14-7
4-(3-Ethoxybenzoyl)-3-hydroxy-1-(2-methoxyethyl)-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one
CAS 608500-14-7C20H21NO5S
3-Hydroxy-4-(3-methoxybenzoyl)-1-(3-methoxypropyl)-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C20H21NO5S, CAS 608501-43-5
3-Hydroxy-4-(3-methoxybenzoyl)-1-(3-methoxypropyl)-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one
CAS 608501-43-5C20H21NO5S
4-(3-Ethoxybenzoyl)-3-hydroxy-1-(3-methoxypropyl)-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C21H23NO5S, CAS 608501-86-6
4-(3-Ethoxybenzoyl)-3-hydroxy-1-(3-methoxypropyl)-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one
CAS 608501-86-6C21H23NO5S
1-[2-(Dimethylamino)ethyl]-4-(3-ethoxybenzoyl)-3-hydroxy-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C21H24N2O4S, CAS 608503-60-2
1-[2-(Dimethylamino)ethyl]-4-(3-ethoxybenzoyl)-3-hydroxy-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one
CAS 608503-60-2C21H24N2O4S
1-[2-(Dimethylamino)ethyl]-3-hydroxy-4-(3-propoxybenzoyl)-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C22H26N2O4S, CAS 608504-03-6
1-[2-(Dimethylamino)ethyl]-3-hydroxy-4-(3-propoxybenzoyl)-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one
CAS 608504-03-6C22H26N2O4S
1-[2-(Diethylamino)ethyl]-4-[hydroxy-(3-methoxyphenyl)methylidene]-5-thiophen-2-ylpyrrolidine-2,3-dione chemical structure, C22H26N2O4S
1-[2-(Diethylamino)ethyl]-4-[hydroxy-(3-methoxyphenyl)methylidene]-5-thiophen-2-ylpyrrolidine-2,3-dione
C22H26N2O4S
1-[3-(Dimethylamino)propyl]-4-(2,5-dimethylbenzoyl)-3-hydroxy-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C22H26N2O3S
1-[3-(Dimethylamino)propyl]-4-(2,5-dimethylbenzoyl)-3-hydroxy-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one
C22H26N2O3S
4-(2,5-Dimethylbenzoyl)-3-hydroxy-1-(2-methoxyethyl)-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C20H21NO4S, CAS 607689-95-2
4-(2,5-Dimethylbenzoyl)-3-hydroxy-1-(2-methoxyethyl)-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one
CAS 607689-95-2C20H21NO4S
1-[2-(Dimethylamino)ethyl]-4-(2,5-dimethylbenzoyl)-3-hydroxy-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C21H24N2O3S
1-[2-(Dimethylamino)ethyl]-4-(2,5-dimethylbenzoyl)-3-hydroxy-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one
C21H24N2O3S
1-[3-(Diethylamino)propyl]-4-[(2,5-dimethylphenyl)-hydroxymethylidene]-5-thiophen-2-ylpyrrolidine-2,3-dione chemical structure, C24H30N2O3S
1-[3-(Diethylamino)propyl]-4-[(2,5-dimethylphenyl)-hydroxymethylidene]-5-thiophen-2-ylpyrrolidine-2,3-dione
C24H30N2O3S
1-(2-(Dimethylamino)ethyl)-4-(3-fluoro-4-methylbenzoyl)-3-hydroxy-5-(thiophen-2-yl)-1H-pyrrol-2(5H)-one chemical structure, C20H21FN2O3S, CAS 618075-93-7
1-(2-(Dimethylamino)ethyl)-4-(3-fluoro-4-methylbenzoyl)-3-hydroxy-5-(thiophen-2-yl)-1H-pyrrol-2(5H)-one
CAS 618075-93-7C20H21FN2O3S
1-[2-(Dimethylamino)ethyl]-3-hydroxy-4-[3-methyl-4-(2-methylpropoxy)benzoyl]-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H30N2O4S
1-[2-(Dimethylamino)ethyl]-3-hydroxy-4-[3-methyl-4-(2-methylpropoxy)benzoyl]-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one
C24H30N2O4S
4-Benzoyl-1-[2-(dimethylamino)ethyl]-3-hydroxy-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C19H20N2O3S
4-Benzoyl-1-[2-(dimethylamino)ethyl]-3-hydroxy-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one
C19H20N2O3S
1-[2-(Diethylamino)ethyl]-3-hydroxy-4-[4-(propan-2-yloxy)benzoyl]-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H30N2O4S
1-[2-(Diethylamino)ethyl]-3-hydroxy-4-[4-(propan-2-yloxy)benzoyl]-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one
C24H30N2O4S
1-[3-(Dimethylamino)propyl]-3-hydroxy-4-[4-(prop-2-en-1-yloxy)benzoyl]-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H26N2O4S
1-[3-(Dimethylamino)propyl]-3-hydroxy-4-[4-(prop-2-en-1-yloxy)benzoyl]-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one
C23H26N2O4S
3-Hydroxy-1-(3-methoxypropyl)-4-[4-(2-methylpropoxy)benzoyl]-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H27NO5S
3-Hydroxy-1-(3-methoxypropyl)-4-[4-(2-methylpropoxy)benzoyl]-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one
C23H27NO5S
1-[3-(Dimethylamino)propyl]-4-[hydroxy-[2-methyl-4-(2-methylpropoxy)phenyl]methylidene]-5-thiophen-2-ylpyrrolidine-2,3-dione chemical structure, C25H32N2O4S
1-[3-(Dimethylamino)propyl]-4-[hydroxy-[2-methyl-4-(2-methylpropoxy)phenyl]methylidene]-5-thiophen-2-ylpyrrolidine-2,3-dione
C25H32N2O4S
4-Benzoyl-1-[3-(diethylamino)propyl]-3-hydroxy-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C22H26N2O3S
4-Benzoyl-1-[3-(diethylamino)propyl]-3-hydroxy-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one
C22H26N2O3S
1-[3-(Dimethylamino)propyl]-3-hydroxy-4-[4-(2-methylpropoxy)benzoyl]-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H30N2O4S
1-[3-(Dimethylamino)propyl]-3-hydroxy-4-[4-(2-methylpropoxy)benzoyl]-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one
C24H30N2O4S
1-[2-(Dimethylamino)ethyl]-3-hydroxy-4-[4-(2-methylpropoxy)benzoyl]-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H28N2O4S
1-[2-(Dimethylamino)ethyl]-3-hydroxy-4-[4-(2-methylpropoxy)benzoyl]-5-(thiophen-2-yl)-2,5-dihydro-1H-pyrrol-2-one
C23H28N2O4S