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Murcko scaffold

Ring system with 3 rings and 19 atoms

99 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 19
Chemicals: 99
With full pages: 3

Scaffold SMILES

O=C1NC(c2ccco2)C(=Cc2ccccc2)C1=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1NC(c2ccco2)C(=Cc2ccccc2)C1=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 99 chemicals

3-Hydroxy-4-(3-methoxybenzoyl)-1-(2-methoxyethyl)-5-(5-methylfuran-2-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C20H21NO6

3-Hydroxy-4-(3-methoxybenzoyl)-1-(2-methoxyethyl)-5-(5-methylfuran-2-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₀H₂₁NO₆

5-(Furan-2-yl)-3-hydroxy-4-(3-methoxybenzoyl)-1-(2-methoxyethyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C19H19NO6

5-(Furan-2-yl)-3-hydroxy-4-(3-methoxybenzoyl)-1-(2-methoxyethyl)-2,5-dihydro-1H-pyrrol-2-one

C₁₉H₁₉NO₆

4-(3-Ethoxybenzoyl)-3-hydroxy-1-(2-methoxyethyl)-5-(5-methylfuran-2-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C21H23NO6

4-(3-Ethoxybenzoyl)-3-hydroxy-1-(2-methoxyethyl)-5-(5-methylfuran-2-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₁H₂₃NO₆

4-(3-Ethoxybenzoyl)-5-(furan-2-yl)-3-hydroxy-1-(2-methoxyethyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C20H21NO6

4-(3-Ethoxybenzoyl)-5-(furan-2-yl)-3-hydroxy-1-(2-methoxyethyl)-2,5-dihydro-1H-pyrrol-2-one

C₂₀H₂₁NO₆

1-[2-(Diethylamino)ethyl]-4-(4-ethoxybenzoyl)-5-(furan-2-yl)-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H28N2O5

1-[2-(Diethylamino)ethyl]-4-(4-ethoxybenzoyl)-5-(furan-2-yl)-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one

C₂₃H₂₈N₂O₅

1-[3-(Diethylamino)propyl]-5-(furan-2-yl)-3-hydroxy-4-(4-methoxybenzoyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H28N2O5

1-[3-(Diethylamino)propyl]-5-(furan-2-yl)-3-hydroxy-4-(4-methoxybenzoyl)-2,5-dihydro-1H-pyrrol-2-one

C₂₃H₂₈N₂O₅

1-[3-(Dimethylamino)propyl]-3-hydroxy-4-(4-methylbenzoyl)-5-(5-methylfuran-2-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C22H26N2O4

1-[3-(Dimethylamino)propyl]-3-hydroxy-4-(4-methylbenzoyl)-5-(5-methylfuran-2-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₂H₂₆N₂O₄

4-Benzoyl-1-[2-(dimethylamino)ethyl]-5-(furan-2-yl)-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one chemical structure, C19H20N2O4

4-Benzoyl-1-[2-(dimethylamino)ethyl]-5-(furan-2-yl)-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one

C₁₉H₂₀N₂O₄

4-(4-Chlorobenzoyl)-1-[3-(diethylamino)propyl]-3-hydroxy-5-(5-methylfuran-2-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H27ClN2O4, CAS 608107-87-5

4-(4-Chlorobenzoyl)-1-[3-(diethylamino)propyl]-3-hydroxy-5-(5-methylfuran-2-yl)-2,5-dihydro-1H-pyrrol-2-one

CAS 608107-87-5C₂₃H₂₇ClN₂O₄

1-[3-(Diethylamino)propyl]-5-(furan-2-yl)-3-hydroxy-4-(4-methylbenzoyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H28N2O4, CAS 608108-40-3

1-[3-(Diethylamino)propyl]-5-(furan-2-yl)-3-hydroxy-4-(4-methylbenzoyl)-2,5-dihydro-1H-pyrrol-2-one

CAS 608108-40-3C₂₃H₂₈N₂O₄

1-[3-(Diethylamino)propyl]-3-hydroxy-4-(4-methylbenzoyl)-5-(5-methylfuran-2-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H30N2O4, CAS 608108-76-5

1-[3-(Diethylamino)propyl]-3-hydroxy-4-(4-methylbenzoyl)-5-(5-methylfuran-2-yl)-2,5-dihydro-1H-pyrrol-2-one

CAS 608108-76-5C₂₄H₃₀N₂O₄

1-[3-(Dimethylamino)propyl]-5-(furan-2-yl)-3-hydroxy-4-(3-methoxybenzoyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C21H24N2O5

1-[3-(Dimethylamino)propyl]-5-(furan-2-yl)-3-hydroxy-4-(3-methoxybenzoyl)-2,5-dihydro-1H-pyrrol-2-one

C₂₁H₂₄N₂O₅

1-[3-(Dimethylamino)propyl]-4-(3-ethoxybenzoyl)-3-hydroxy-5-(5-methylfuran-2-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H28N2O5, CAS 608498-75-5

1-[3-(Dimethylamino)propyl]-4-(3-ethoxybenzoyl)-3-hydroxy-5-(5-methylfuran-2-yl)-2,5-dihydro-1H-pyrrol-2-one

CAS 608498-75-5C₂₃H₂₈N₂O₅

5-(Furan-2-yl)-4-[hydroxy-(3-methoxyphenyl)methylidene]-1-(3-methoxypropyl)pyrrolidine-2,3-dione chemical structure, C20H21NO6

5-(Furan-2-yl)-4-[hydroxy-(3-methoxyphenyl)methylidene]-1-(3-methoxypropyl)pyrrolidine-2,3-dione

C₂₀H₂₁NO₆

4-[(3-Ethoxyphenyl)-hydroxymethylidene]-5-(furan-2-yl)-1-(3-methoxypropyl)pyrrolidine-2,3-dione chemical structure, C21H23NO6

4-[(3-Ethoxyphenyl)-hydroxymethylidene]-5-(furan-2-yl)-1-(3-methoxypropyl)pyrrolidine-2,3-dione

C₂₁H₂₃NO₆

1-[2-(Dimethylamino)ethyl]-5-(furan-2-yl)-3-hydroxy-4-(3-methoxybenzoyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C20H22N2O5

1-[2-(Dimethylamino)ethyl]-5-(furan-2-yl)-3-hydroxy-4-(3-methoxybenzoyl)-2,5-dihydro-1H-pyrrol-2-one

C₂₀H₂₂N₂O₅

1-[2-(Dimethylamino)ethyl]-4-(3-ethoxybenzoyl)-5-(furan-2-yl)-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one chemical structure, C21H24N2O5, CAS 608503-75-9

1-[2-(Dimethylamino)ethyl]-4-(3-ethoxybenzoyl)-5-(furan-2-yl)-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one

CAS 608503-75-9C₂₁H₂₄N₂O₅

1-[2-(Dimethylamino)ethyl]-4-(3-ethoxybenzoyl)-3-hydroxy-5-(5-methylfuran-2-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C22H26N2O5

1-[2-(Dimethylamino)ethyl]-4-(3-ethoxybenzoyl)-3-hydroxy-5-(5-methylfuran-2-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₂H₂₆N₂O₅

1-[2-(Dimethylamino)ethyl]-5-(furan-2-yl)-3-hydroxy-4-(3-propoxybenzoyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C22H26N2O5, CAS 608504-19-4

1-[2-(Dimethylamino)ethyl]-5-(furan-2-yl)-3-hydroxy-4-(3-propoxybenzoyl)-2,5-dihydro-1H-pyrrol-2-one

CAS 608504-19-4C₂₂H₂₆N₂O₅

1-[2-(Diethylamino)ethyl]-5-(furan-2-yl)-3-hydroxy-4-(3-methoxybenzoyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C22H26N2O5, CAS 608508-53-8

1-[2-(Diethylamino)ethyl]-5-(furan-2-yl)-3-hydroxy-4-(3-methoxybenzoyl)-2,5-dihydro-1H-pyrrol-2-one

CAS 608508-53-8C₂₂H₂₆N₂O₅

1-[2-(Diethylamino)ethyl]-3-hydroxy-4-(3-methoxybenzoyl)-5-(5-methylfuran-2-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H28N2O5, CAS 608508-71-0

1-[2-(Diethylamino)ethyl]-3-hydroxy-4-(3-methoxybenzoyl)-5-(5-methylfuran-2-yl)-2,5-dihydro-1H-pyrrol-2-one

CAS 608508-71-0C₂₃H₂₈N₂O₅

1-[2-(Dimethylamino)ethyl]-4-(2,5-dimethylbenzoyl)-5-(furan-2-yl)-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one chemical structure, C21H24N2O4

1-[2-(Dimethylamino)ethyl]-4-(2,5-dimethylbenzoyl)-5-(furan-2-yl)-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one

C₂₁H₂₄N₂O₄

4-(4-Chlorobenzoyl)-1-[2-(diethylamino)ethyl]-5-(furan-2-yl)-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one chemical structure, C21H23ClN2O4

4-(4-Chlorobenzoyl)-1-[2-(diethylamino)ethyl]-5-(furan-2-yl)-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one

C₂₁H₂₃ClN₂O₄

1-[3-(Dimethylamino)propyl]-5-(furan-2-yl)-3-hydroxy-4-(4-propoxybenzoyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H28N2O5

1-[3-(Dimethylamino)propyl]-5-(furan-2-yl)-3-hydroxy-4-(4-propoxybenzoyl)-2,5-dihydro-1H-pyrrol-2-one

C₂₃H₂₈N₂O₅