Murcko scaffold
Ring system with 4 rings and 25 atoms
17 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 25
- Chemicals
- 17
- With full pages
- 6
Scaffold SMILES
O=C1C(=O)N(c2nccs2)C(c2cccnc2)C1=Cc1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 17 of 17 chemicals
![Ethyl 2-[3-hydroxy-4-(4-methoxy-2-methylbenzoyl)-2-oxo-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-1-yl]-4-methyl-1,3-thiazole-5-carboxylate chemical structure, C25H23N3O6S](/s/WOLYQVHFSQXHKZ-UHFFFAOYSA-N.svg)
Ethyl 2-[3-hydroxy-4-(4-methoxy-2-methylbenzoyl)-2-oxo-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-1-yl]-4-methyl-1,3-thiazole-5-carboxylate
C25H23N3O6S
3-Hydroxy-4-(3-propoxybenzoyl)-5-(pyridin-3-yl)-1-(1,3-thiazol-2-yl)-2,5-dihydro-1H-pyrrol-2-one
C22H19N3O4S
1-(5-Acetyl-4-methyl-1,3-thiazol-2-yl)-4-(2,5-dimethylbenzoyl)-3-hydroxy-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one
CAS 608091-26-5C24H21N3O4S
![Methyl 2-{3-hydroxy-2-oxo-4-[4-(propan-2-yloxy)benzoyl]-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-1-yl}-4-methyl-1,3-thiazole-5-carboxylate chemical structure, C25H23N3O6S](/s/SYSCGTICYKCBPW-UHFFFAOYSA-N.svg)
Methyl 2-{3-hydroxy-2-oxo-4-[4-(propan-2-yloxy)benzoyl]-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-1-yl}-4-methyl-1,3-thiazole-5-carboxylate
C25H23N3O6S
![Methyl 2-[3-hydroxy-2-oxo-4-(4-propoxybenzoyl)-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-1-yl]-4-methyl-1,3-thiazole-5-carboxylate chemical structure, C25H23N3O6S](/s/LYBAVVRRLXQUAB-UHFFFAOYSA-N.svg)
Methyl 2-[3-hydroxy-2-oxo-4-(4-propoxybenzoyl)-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-1-yl]-4-methyl-1,3-thiazole-5-carboxylate
C25H23N3O6S
![Ethyl 2-[(3E)-3-[hydroxy(4-methoxy-2-methylphenyl)methylidene]-4,5-dioxo-2-(pyridin-3-yl)pyrrolidin-1-yl]-4-methyl-1,3-thiazole-5-carboxylate chemical structure, C25H23N3O6S, CAS 459793-77-2](/s/WOLYQVHFSQXHKZ-CZIZESTLSA-N.svg)
Ethyl 2-[(3E)-3-[hydroxy(4-methoxy-2-methylphenyl)methylidene]-4,5-dioxo-2-(pyridin-3-yl)pyrrolidin-1-yl]-4-methyl-1,3-thiazole-5-carboxylate
CAS 459793-77-2C25H23N3O6S
![Ethyl 2-[3-hydroxy-4-(4-methoxy-3-methylbenzoyl)-2-oxo-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-1-yl]-4-methyl-1,3-thiazole-5-carboxylate chemical structure, C25H23N3O6S, CAS 433250-20-5](/s/IVHKMKZELOSETG-CZIZESTLSA-N.svg)
Ethyl 2-[3-hydroxy-4-(4-methoxy-3-methylbenzoyl)-2-oxo-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-1-yl]-4-methyl-1,3-thiazole-5-carboxylate
CAS 433250-20-5C25H23N3O6S
![(4E)-4-[Hydroxy-(3-propoxyphenyl)methylidene]-5-pyridin-3-yl-1-(1,3-thiazol-2-yl)pyrrolidine-2,3-dione chemical structure, C22H19N3O4S, CAS 609320-63-0](/s/KYBMDGQFYPOONZ-HTXNQAPBSA-N.svg)
(4E)-4-[Hydroxy-(3-propoxyphenyl)methylidene]-5-pyridin-3-yl-1-(1,3-thiazol-2-yl)pyrrolidine-2,3-dione
CAS 609320-63-0C22H19N3O4S
![(4E)-1-(5-Acetyl-4-methyl-1,3-thiazol-2-yl)-4-[(2,5-dimethylphenyl)-hydroxymethylidene]-5-pyridin-3-ylpyrrolidine-2,3-dione chemical structure, C24H21N3O4S](/s/YIEXIMQUBQOAKC-CZIZESTLSA-N.svg)
(4E)-1-(5-Acetyl-4-methyl-1,3-thiazol-2-yl)-4-[(2,5-dimethylphenyl)-hydroxymethylidene]-5-pyridin-3-ylpyrrolidine-2,3-dione
C24H21N3O4S
![Ethyl 2-[3-(3-fluoro-4-methylbenzoyl)-4-hydroxy-5-oxo-2-(3-pyridinyl)-2,5-dihy dro-1H-pyrrol-1-yl]-4-methyl-1,3-thiazole-5-carboxylate chemical structure, C24H20FN3O5S, CAS 618072-71-2](/s/KECDQGHQDRKJEE-HTXNQAPBSA-N.svg)
Ethyl 2-[3-(3-fluoro-4-methylbenzoyl)-4-hydroxy-5-oxo-2-(3-pyridinyl)-2,5-dihy dro-1H-pyrrol-1-yl]-4-methyl-1,3-thiazole-5-carboxylate
CAS 618072-71-2C24H20FN3O5S
![Ethyl 2-[3-(4-butoxybenzoyl)-4-hydroxy-5-oxo-2-(3-pyridinyl)-2,5-dihydro-1H-pyrrol-1-yl]-4-methyl-1,3-thiazole-5-carboxylate chemical structure, C27H27N3O6S, CAS 609796-51-2](/s/FOZCXYPBVAMDQA-LSDHQDQOSA-N.svg)
Ethyl 2-[3-(4-butoxybenzoyl)-4-hydroxy-5-oxo-2-(3-pyridinyl)-2,5-dihydro-1H-pyrrol-1-yl]-4-methyl-1,3-thiazole-5-carboxylate
CAS 609796-51-2C27H27N3O6S
Methyl 2-(3-(3-fluoro-4-methylbenzoyl)-4-hydroxy-5-oxo-2-(3-pyridinyl)-2,5-dihy dro-1H-pyrrol-1-yl)-4-methyl-1,3-thiazole-5-carboxylate
CAS 617698-27-8C23H18FN3O5S
![Methyl 2-[(3E)-3-{hydroxy[4-(propan-2-yloxy)phenyl]methylidene}-4,5-dioxo-2-(pyridin-3-yl)pyrrolidin-1-yl]-4-methyl-1,3-thiazole-5-carboxylate chemical structure, C25H23N3O6S, CAS 847857-08-3](/s/SYSCGTICYKCBPW-CZIZESTLSA-N.svg)
Methyl 2-[(3E)-3-{hydroxy[4-(propan-2-yloxy)phenyl]methylidene}-4,5-dioxo-2-(pyridin-3-yl)pyrrolidin-1-yl]-4-methyl-1,3-thiazole-5-carboxylate
CAS 847857-08-3C25H23N3O6S
![Methyl 2-[(3E)-3-[hydroxy(4-propoxyphenyl)methylidene]-4,5-dioxo-2-(pyridin-3-yl)pyrrolidin-1-yl]-4-methyl-1,3-thiazole-5-carboxylate chemical structure, C25H23N3O6S, CAS 843670-76-8](/s/LYBAVVRRLXQUAB-CZIZESTLSA-N.svg)
Methyl 2-[(3E)-3-[hydroxy(4-propoxyphenyl)methylidene]-4,5-dioxo-2-(pyridin-3-yl)pyrrolidin-1-yl]-4-methyl-1,3-thiazole-5-carboxylate
CAS 843670-76-8C25H23N3O6S
Allyl 2-(3-(3-fluoro-4-methylbenzoyl)-4-hydroxy-5-oxo-2-(3-pyridinyl)-2,5-dihy dro-1H-pyrrol-1-yl)-4-methyl-1,3-thiazole-5-carboxylate
CAS 618071-78-6C25H20FN3O5S
![Allyl 2-[3-(4-butoxybenzoyl)-4-hydroxy-5-oxo-2-(3-pyridinyl)-2,5-dihydro-1H-pyrrol-1-yl]-4-methyl-1,3-thiazole-5-carboxylate chemical structure, C28H27N3O6S, CAS 609796-78-3](/s/YFVDKXZTMYBDMK-LNVKXUELSA-N.svg)
Allyl 2-[3-(4-butoxybenzoyl)-4-hydroxy-5-oxo-2-(3-pyridinyl)-2,5-dihydro-1H-pyrrol-1-yl]-4-methyl-1,3-thiazole-5-carboxylate
CAS 609796-78-3C28H27N3O6S
Methyl 2-(3-(4-butoxybenzoyl)-4-hydroxy-5-oxo-2-(3-pyridinyl)-2,5-dihydro-1H-pyrrol-1-yl)-4-methyl-1,3-thiazole-5-carboxylate
CAS 617695-39-3C26H25N3O6S
Related scaffolds
Same ring framework with different atoms or bond orders
