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Murcko scaffold

Ring system with 4 rings and 25 atoms

341 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
341
With full pages
127
Scaffold SMILES

O=C1C(=O)N(c2nccs2)C(c2ccccc2)C1=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1C(=O)N(c2nccs2)C(c2ccccc2)C1=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 341 chemicals

4-[(4-Chlorophenyl)-hydroxymethylidene]-5-(4-fluorophenyl)-1-(1,3-thiazol-2-yl)pyrrolidine-2,3-dione chemical structure, C20H12ClFN2O3S
4-[(4-Chlorophenyl)-hydroxymethylidene]-5-(4-fluorophenyl)-1-(1,3-thiazol-2-yl)pyrrolidine-2,3-dione
C20H12ClFN2O3S
5-(3-Chlorophenyl)-4-[(4-chlorophenyl)-hydroxymethylidene]-1-(1,3-thiazol-2-yl)pyrrolidine-2,3-dione chemical structure, C20H12Cl2N2O3S
5-(3-Chlorophenyl)-4-[(4-chlorophenyl)-hydroxymethylidene]-1-(1,3-thiazol-2-yl)pyrrolidine-2,3-dione
C20H12Cl2N2O3S
5-(3-Bromophenyl)-4-[(4-fluorophenyl)-hydroxymethylidene]-1-(1,3-thiazol-2-yl)pyrrolidine-2,3-dione chemical structure, C20H12BrFN2O3S
5-(3-Bromophenyl)-4-[(4-fluorophenyl)-hydroxymethylidene]-1-(1,3-thiazol-2-yl)pyrrolidine-2,3-dione
C20H12BrFN2O3S
4-(4-Fluorobenzoyl)-3-hydroxy-5-[4-(propan-2-yl)phenyl]-1-(1,3-thiazol-2-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H19FN2O3S
4-(4-Fluorobenzoyl)-3-hydroxy-5-[4-(propan-2-yl)phenyl]-1-(1,3-thiazol-2-yl)-2,5-dihydro-1H-pyrrol-2-one
C23H19FN2O3S
5-(4-Chlorophenyl)-4-(4-ethoxybenzoyl)-3-hydroxy-1-(thiazol-2-yl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C22H17ClN2O4S
5-(4-Chlorophenyl)-4-(4-ethoxybenzoyl)-3-hydroxy-1-(thiazol-2-yl)-1,5-dihydro-2H-pyrrol-2-one
C22H17ClN2O4S
4-(4-Ethoxybenzoyl)-5-(4-fluorophenyl)-3-hydroxy-1-(thiazol-2-yl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C22H17FN2O4S
4-(4-Ethoxybenzoyl)-5-(4-fluorophenyl)-3-hydroxy-1-(thiazol-2-yl)-1,5-dihydro-2H-pyrrol-2-one
C22H17FN2O4S
4-[(4-Fluorophenyl)-hydroxymethylidene]-5-(4-methylphenyl)-1-(1,3-thiazol-2-yl)pyrrolidine-2,3-dione chemical structure, C21H15FN2O3S
4-[(4-Fluorophenyl)-hydroxymethylidene]-5-(4-methylphenyl)-1-(1,3-thiazol-2-yl)pyrrolidine-2,3-dione
C21H15FN2O3S
4-[(4-Fluorophenyl)-hydroxymethylidene]-5-(4-methoxyphenyl)-1-(1,3-thiazol-2-yl)pyrrolidine-2,3-dione chemical structure, C21H15FN2O4S
4-[(4-Fluorophenyl)-hydroxymethylidene]-5-(4-methoxyphenyl)-1-(1,3-thiazol-2-yl)pyrrolidine-2,3-dione
C21H15FN2O4S
5-(4-Chlorophenyl)-4-[hydroxy-(4-methylphenyl)methylidene]-1-(1,3-thiazol-2-yl)pyrrolidine-2,3-dione chemical structure, C21H15ClN2O3S
5-(4-Chlorophenyl)-4-[hydroxy-(4-methylphenyl)methylidene]-1-(1,3-thiazol-2-yl)pyrrolidine-2,3-dione
C21H15ClN2O3S
Methyl 2-[3-hydroxy-4-(4-methoxy-2-methylbenzoyl)-5-(4-methylphenyl)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl]-4-methyl-1,3-thiazole-5-carboxylate chemical structure, C26H24N2O6S
Methyl 2-[3-hydroxy-4-(4-methoxy-2-methylbenzoyl)-5-(4-methylphenyl)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl]-4-methyl-1,3-thiazole-5-carboxylate
C26H24N2O6S
Ethyl 2-[3-hydroxy-4-(4-methoxy-2-methylbenzoyl)-2-oxo-5-phenyl-2,5-dihydro-1H-pyrrol-1-yl]-4-methyl-1,3-thiazole-5-carboxylate chemical structure, C26H24N2O6S
Ethyl 2-[3-hydroxy-4-(4-methoxy-2-methylbenzoyl)-2-oxo-5-phenyl-2,5-dihydro-1H-pyrrol-1-yl]-4-methyl-1,3-thiazole-5-carboxylate
C26H24N2O6S
Methyl 2-[3-hydroxy-4-(4-methoxy-3-methylbenzoyl)-2-oxo-5-phenyl-2,5-dihydro-1H-pyrrol-1-yl]-4-methyl-1,3-thiazole-5-carboxylate chemical structure, C25H22N2O6S
Methyl 2-[3-hydroxy-4-(4-methoxy-3-methylbenzoyl)-2-oxo-5-phenyl-2,5-dihydro-1H-pyrrol-1-yl]-4-methyl-1,3-thiazole-5-carboxylate
C25H22N2O6S
Methyl 2-[3-hydroxy-5-(4-hydroxyphenyl)-4-(4-methoxy-3-methylbenzoyl)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl]-4-methyl-1,3-thiazole-5-carboxylate chemical structure, C25H22N2O7S
Methyl 2-[3-hydroxy-5-(4-hydroxyphenyl)-4-(4-methoxy-3-methylbenzoyl)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl]-4-methyl-1,3-thiazole-5-carboxylate
C25H22N2O7S
1-(5-Acetyl-4-methyl-1,3-thiazol-2-yl)-3-hydroxy-4-(4-methoxybenzoyl)-5-(4-methylphenyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H22N2O5S
1-(5-Acetyl-4-methyl-1,3-thiazol-2-yl)-3-hydroxy-4-(4-methoxybenzoyl)-5-(4-methylphenyl)-2,5-dihydro-1H-pyrrol-2-one
C25H22N2O5S
Ethyl 2-[3-[hydroxy-(4-methylphenyl)methylidene]-2-(4-methylphenyl)-4,5-dioxopyrrolidin-1-yl]-4-methyl-1,3-thiazole-5-carboxylate chemical structure, C26H24N2O5S
Ethyl 2-[3-[hydroxy-(4-methylphenyl)methylidene]-2-(4-methylphenyl)-4,5-dioxopyrrolidin-1-yl]-4-methyl-1,3-thiazole-5-carboxylate
C26H24N2O5S
Methyl 2-[3-[(4-chlorophenyl)-hydroxymethylidene]-2-(2-fluorophenyl)-4,5-dioxopyrrolidin-1-yl]-4-methyl-1,3-thiazole-5-carboxylate chemical structure, C23H16ClFN2O5S
Methyl 2-[3-[(4-chlorophenyl)-hydroxymethylidene]-2-(2-fluorophenyl)-4,5-dioxopyrrolidin-1-yl]-4-methyl-1,3-thiazole-5-carboxylate
C23H16ClFN2O5S
Methyl 2-[3-benzoyl-2-(3,4-dimethoxyphenyl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl]-4-methyl-1,3-thiazole-5-carboxylate chemical structure, C25H22N2O7S
Methyl 2-[3-benzoyl-2-(3,4-dimethoxyphenyl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl]-4-methyl-1,3-thiazole-5-carboxylate
C25H22N2O7S
1-(5-Acetyl-4-methyl-1,3-thiazol-2-yl)-5-(3-ethoxyphenyl)-3-hydroxy-4-(4-methylbenzoyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H24N2O5S
1-(5-Acetyl-4-methyl-1,3-thiazol-2-yl)-5-(3-ethoxyphenyl)-3-hydroxy-4-(4-methylbenzoyl)-2,5-dihydro-1H-pyrrol-2-one
C26H24N2O5S
5-(4-Chlorophenyl)-4-[(4-chlorophenyl)-hydroxymethylidene]-1-(1,3-thiazol-2-yl)pyrrolidine-2,3-dione chemical structure, C20H12Cl2N2O3S
5-(4-Chlorophenyl)-4-[(4-chlorophenyl)-hydroxymethylidene]-1-(1,3-thiazol-2-yl)pyrrolidine-2,3-dione
C20H12Cl2N2O3S
Ethyl 2-[2-(4-chlorophenyl)-3-[hydroxy-(4-methylphenyl)methylidene]-4,5-dioxopyrrolidin-1-yl]-4-methyl-1,3-thiazole-5-carboxylate chemical structure, C25H21ClN2O5S
Ethyl 2-[2-(4-chlorophenyl)-3-[hydroxy-(4-methylphenyl)methylidene]-4,5-dioxopyrrolidin-1-yl]-4-methyl-1,3-thiazole-5-carboxylate
C25H21ClN2O5S
Ethyl 2-[4-[hydroxy-(4-methylphenyl)methylidene]-2,3-dioxo-5-phenylpyrrolidin-1-yl]-4-methyl-1,3-thiazole-5-carboxylate chemical structure, C25H22N2O5S
Ethyl 2-[4-[hydroxy-(4-methylphenyl)methylidene]-2,3-dioxo-5-phenylpyrrolidin-1-yl]-4-methyl-1,3-thiazole-5-carboxylate
C25H22N2O5S
5-(4-tert-Butylphenyl)-4-[hydroxy-(4-methylphenyl)methylidene]-1-(1,3-thiazol-2-yl)pyrrolidine-2,3-dione chemical structure, C25H24N2O3S
5-(4-tert-Butylphenyl)-4-[hydroxy-(4-methylphenyl)methylidene]-1-(1,3-thiazol-2-yl)pyrrolidine-2,3-dione
C25H24N2O3S
5-(2-Chlorophenyl)-4-[(4-fluorophenyl)-hydroxymethylidene]-1-(1,3-thiazol-2-yl)pyrrolidine-2,3-dione chemical structure, C20H12ClFN2O3S
5-(2-Chlorophenyl)-4-[(4-fluorophenyl)-hydroxymethylidene]-1-(1,3-thiazol-2-yl)pyrrolidine-2,3-dione
C20H12ClFN2O3S
1-(5-Acetyl-4-methyl-1,3-thiazol-2-yl)-5-(4-chlorophenyl)-3-hydroxy-4-(4-methoxybenzoyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H19ClN2O5S
1-(5-Acetyl-4-methyl-1,3-thiazol-2-yl)-5-(4-chlorophenyl)-3-hydroxy-4-(4-methoxybenzoyl)-2,5-dihydro-1H-pyrrol-2-one
C24H19ClN2O5S