Murcko scaffold
Ring system with 4 rings and 25 atoms
167 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 25
- Chemicals
- 167
- With full pages
- 5
Scaffold SMILES
O=C1C(=O)N(c2ccon2)C(c2ccccc2)C1=Cc1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 167 chemicals
4-(3,4-Dimethoxybenzoyl)-5-(3,4-dimethoxyphenyl)-3-hydroxy-1-(5-methyl-1,2-oxazol-3-yl)-2,5-dihydro-1H-pyrrol-2-one
C25H24N2O8
5-(4-Ethoxy-3-methoxyphenyl)-3-hydroxy-4-(4-methoxybenzoyl)-1-(5-methyl-1,2-oxazol-3-yl)-2,5-dihydro-1H-pyrrol-2-one
C25H24N2O7
5-(3-Chlorophenyl)-3-hydroxy-1-(5-methyl-1,2-oxazol-3-yl)-4-(4-methylbenzoyl)-2,5-dihydro-1H-pyrrol-2-one
C22H17ClN2O4
5-(3-Ethoxy-4-hydroxyphenyl)-3-hydroxy-1-(5-methyl-1,2-oxazol-3-yl)-4-(4-propoxybenzoyl)-2,5-dihydro-1H-pyrrol-2-one
C26H26N2O7
![2,3-Pyrrolidinedione, 4-[(3,4-dimethoxyphenyl)hydroxymethylene]-5-[4-(1-methylethyl)phenyl]-1-(5-methyl-3-isoxazolyl)- chemical structure, C26H26N2O6, CAS 898796-64-0](/s/BMRSRZKRIBVYID-UHFFFAOYSA-N.svg)
2,3-Pyrrolidinedione, 4-[(3,4-dimethoxyphenyl)hydroxymethylene]-5-[4-(1-methylethyl)phenyl]-1-(5-methyl-3-isoxazolyl)-
CAS 898796-64-0C26H26N2O6
5-(4-Ethylphenyl)-4-(4-fluorobenzoyl)-3-hydroxy-1-(5-methyl-1,2-oxazol-3-yl)-2,5-dihydro-1H-pyrrol-2-one
C23H19FN2O4
5-(3-Ethoxy-4-hydroxyphenyl)-3-hydroxy-4-(4-methoxybenzoyl)-1-(5-methyl-1,2-oxazol-3-yl)-2,5-dihydro-1H-pyrrol-2-one
C24H22N2O7
5-(4-Butoxyphenyl)-4-(4-fluorobenzoyl)-3-hydroxy-1-(5-methyl-1,2-oxazol-3-yl)-2,5-dihydro-1H-pyrrol-2-one
C25H23FN2O5
4-(4-Chlorobenzoyl)-5-(3-chlorophenyl)-3-hydroxy-1-(5-methyl-1,2-oxazol-3-yl)-2,5-dihydro-1H-pyrrol-2-one
C21H14Cl2N2O4
5-(4-Ethylphenyl)-3-hydroxy-1-(5-methyl-1,2-oxazol-3-yl)-4-(4-propoxybenzoyl)-2,5-dihydro-1H-pyrrol-2-one
C26H26N2O5
![5-(2,5-Dimethoxyphenyl)-3-hydroxy-1-(5-methyl-1,2-oxazol-3-yl)-4-[4-(propan-2-yloxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H26N2O7](/s/VQOOOGQPENMAKJ-UHFFFAOYSA-N.svg)
5-(2,5-Dimethoxyphenyl)-3-hydroxy-1-(5-methyl-1,2-oxazol-3-yl)-4-[4-(propan-2-yloxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-one
C26H26N2O7
4-(4-Chlorobenzoyl)-5-(4-ethylphenyl)-3-hydroxy-1-(5-methyl-1,2-oxazol-3-yl)-2,5-dihydro-1H-pyrrol-2-one
C23H19ClN2O4
3-Hydroxy-5-(3-hydroxyphenyl)-4-(4-methoxybenzoyl)-1-(5-methyl-1,2-oxazol-3-yl)-2,5-dihydro-1H-pyrrol-2-one
C22H18N2O6
5-(2,3-Dimethoxyphenyl)-3-hydroxy-1-(5-methyl-1,2-oxazol-3-yl)-4-(4-propoxybenzoyl)-2,5-dihydro-1H-pyrrol-2-one
C26H26N2O7
![5-(3,4-Dimethoxyphenyl)-3-hydroxy-1-(5-methyl-1,2-oxazol-3-yl)-4-[4-(propan-2-yloxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H26N2O7](/s/WSZKKMYQDRATSY-UHFFFAOYSA-N.svg)
5-(3,4-Dimethoxyphenyl)-3-hydroxy-1-(5-methyl-1,2-oxazol-3-yl)-4-[4-(propan-2-yloxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-one
C26H26N2O7
4-(4-Chlorobenzoyl)-5-(4-fluorophenyl)-3-hydroxy-1-(5-methyl-1,2-oxazol-3-yl)-2,5-dihydro-1H-pyrrol-2-one
C21H14ClFN2O4
4-(4-Chlorobenzoyl)-5-(3,4-dichlorophenyl)-3-hydroxy-1-(5-methyl-1,2-oxazol-3-yl)-2,5-dihydro-1H-pyrrol-2-one
C21H13Cl3N2O4
![5-(3,4-Dimethoxyphenyl)-3-hydroxy-1-(5-methyl-1,2-oxazol-3-yl)-4-[4-(prop-2-en-1-yloxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H24N2O7](/s/USVUMBSARBBLTD-UHFFFAOYSA-N.svg)
5-(3,4-Dimethoxyphenyl)-3-hydroxy-1-(5-methyl-1,2-oxazol-3-yl)-4-[4-(prop-2-en-1-yloxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-one
C26H24N2O7
![4-(4-Fluorobenzoyl)-3-hydroxy-1-(5-methyl-1,2-oxazol-3-yl)-5-[4-(pentyloxy)phenyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H25FN2O5](/s/LBKRDABKPPGKRB-UHFFFAOYSA-N.svg)
4-(4-Fluorobenzoyl)-3-hydroxy-1-(5-methyl-1,2-oxazol-3-yl)-5-[4-(pentyloxy)phenyl]-2,5-dihydro-1H-pyrrol-2-one
C26H25FN2O5
4-(4-Chlorobenzoyl)-5-(2,3-dimethoxyphenyl)-3-hydroxy-1-(5-methyl-1,2-oxazol-3-yl)-2,5-dihydro-1H-pyrrol-2-one
C23H19ClN2O6
5-(3-Ethoxy-4-hydroxyphenyl)-4-(4-ethoxybenzoyl)-3-hydroxy-1-(5-methyl-1,2-oxazol-3-yl)-2,5-dihydro-1H-pyrrol-2-one
C25H24N2O7
![4-[(4-Bromophenyl)(hydroxy)methylidene]-1-(5-methyl-1,2-oxazol-3-yl)-5-{3-[(prop-2-en-1-yl)oxy]phenyl}pyrrolidine-2,3-dione chemical structure, C24H19BrN2O5, CAS 4858-11-1](/s/RWDCZUUIMVDBLQ-UHFFFAOYSA-N.svg)
4-[(4-Bromophenyl)(hydroxy)methylidene]-1-(5-methyl-1,2-oxazol-3-yl)-5-{3-[(prop-2-en-1-yl)oxy]phenyl}pyrrolidine-2,3-dione
CAS 4858-11-1C24H19BrN2O5
![4-(4-Fluorobenzoyl)-3-hydroxy-5-[3-methoxy-4-(3-methylbutoxy)phenyl]-1-(5-methyl-1,2-oxazol-3-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C27H27FN2O6](/s/GBUYBVSYEODCHW-UHFFFAOYSA-N.svg)
4-(4-Fluorobenzoyl)-3-hydroxy-5-[3-methoxy-4-(3-methylbutoxy)phenyl]-1-(5-methyl-1,2-oxazol-3-yl)-2,5-dihydro-1H-pyrrol-2-one
C27H27FN2O6
5-(4-Ethylphenyl)-3-hydroxy-4-(4-methoxybenzoyl)-1-(5-methyl-1,2-oxazol-3-yl)-2,5-dihydro-1H-pyrrol-2-one
C24H22N2O5
- 5-(4-Ethylphenyl)-3-hydroxy-1-(5-methyl-1,2-oxazol-3-yl)-4-(4-methylbenzoyl)-2,5-dihydro-1H-pyrrol-2-oneC24H22N2O4
- 5-(4-Butoxy-3-methoxyphenyl)-4-(4-chlorobenzoyl)-3-hydroxy-1-(5-methyl-1,2-oxazol-3-yl)-2,5-dihydro-1H-pyrrol-2-oneC26H25ClN2O6
- 5-(3,4-Dimethoxyphenyl)-3-hydroxy-4-(4-methoxybenzoyl)-1-(5-methyl-1,2-oxazol-3-yl)-2,5-dihydro-1H-pyrrol-2-oneC24H22N2O7
- 3-Hydroxy-4-(4-methoxybenzoyl)-1-(5-methyl-1,2-oxazol-3-yl)-5-[3-(prop-2-en-1-yloxy)phenyl]-2,5-dihydro-1H-pyrrol-2-oneC25H22N2O6
- 4-(4-Chlorobenzoyl)-3-hydroxy-1-(5-methyl-1,2-oxazol-3-yl)-5-(3,4,5-trimethoxyphenyl)-2,5-dihydro-1H-pyrrol-2-oneC24H21ClN2O7
- 4-Benzoyl-5-(3,4-dichlorophenyl)-3-hydroxy-1-(5-methyl-1,2-oxazol-3-yl)-2,5-dihydro-1H-pyrrol-2-oneC21H14Cl2N2O4
- 4-Benzoyl-5-(3-bromo-4-hydroxy-5-methoxyphenyl)-3-hydroxy-1-(5-methyl-1,2-oxazol-3-yl)-2,5-dihydro-1H-pyrrol-2-oneC22H17BrN2O6
- 5-(3-Bromo-4-hydroxy-5-methoxyphenyl)-3-hydroxy-1-(5-methyl-1,2-oxazol-3-yl)-4-(4-methylbenzoyl)-2,5-dihydro-1H-pyrrol-2-oneC23H19BrN2O6
- 5-(4-tert-Butylphenyl)-4-(3,4-dimethoxybenzoyl)-3-hydroxy-1-(5-methyl-3-isoxazolyl)-1,5-dihydro-2H-pyrrol-2-oneC27H28N2O6
- 4-Benzoyl-3-hydroxy-1-(5-methyl-1,2-oxazol-3-yl)-5-(3,4,5-trimethoxyphenyl)-2,5-dihydro-1H-pyrrol-2-oneC24H22N2O7
- 5-(2,3-Dimethoxyphenyl)-3-hydroxy-4-(3-methoxybenzoyl)-1-(5-methyl-1,2-oxazol-3-yl)-2,5-dihydro-1H-pyrrol-2-oneC24H22N2O7
- 4-(4-Fluorobenzoyl)-5-(4-fluorophenyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one618874-77-4C21H14F2N2O4
- (4E)-5-(3,4-Dimethoxyphenyl)-4-[(3,4-dimethoxyphenyl)(hydroxy)methylidene]-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione618875-55-1C25H24N2O8
- 3-Hydroxy-4-(4-methoxybenzoyl)-5-(2-methoxyphenyl)-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one618876-22-5C23H20N2O6
- 3-Hydroxy-4-(4-methoxy-3-methylbenzoyl)-5-(2-methoxyphenyl)-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one618873-75-9C24H22N2O6
- (4E)-5-(3-Chlorophenyl)-4-[hydroxy(4-methylphenyl)methylidene]-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione848748-47-0C22H17ClN2O4
- 5-(4-Bromophenyl)-3-hydroxy-4-(4-methoxybenzoyl)-1-(5-methyl-1,2-oxazol-3-yl)-2,5-dihydro-1H-pyrrol-2-one618876-12-3C22H17BrN2O5
- Methyl 4-[(3E)-3-[hydroxy(phenyl)methylidene]-1-(5-methyl-1,2-oxazol-3-yl)-4,5-dioxopyrrolidin-2-yl]benzoate618873-62-4C23H18N2O6
- Methyl 4-[(3E)-3-[hydroxy-(4-propan-2-yloxyphenyl)methylidene]-1-(5-methyl-1,2-oxazol-3-yl)-4,5-dioxopyrrolidin-2-yl]benzoate618877-10-4C26H24N2O7
- 4-(4-Chlorobenzoyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-5-(4-nitrophenyl)-1H-pyrrol-2(5H)-one618875-52-8C21H14ClN3O6
- 5-(4-Chlorophenyl)-3-hydroxy-4-(3-methoxybenzoyl)-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one618874-74-1C22H17ClN2O5
- (4E)-5-(3-Ethoxy-4-hydroxyphenyl)-4-[hydroxy(4-propoxyphenyl)methylidene]-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione840482-10-2C26H26N2O7
- 4-(3,4-Dimethoxybenzoyl)-3-hydroxy-5-(4-isopropylphenyl)-1-(5-methyl-3-isoxazolyl)-1,5-dihydro-2H-pyrrol-2-one618875-18-6C26H26N2O6
- 5-(3-Chlorophenyl)-3-hydroxy-4-(4-methoxybenzoyl)-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one618876-03-2C22H17ClN2O5
Related scaffolds
Same ring framework with different atoms or bond orders
