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Murcko scaffold

Ring system with 2 rings and 16 atoms

46 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
16
Chemicals
46
With full pages
17
Scaffold SMILES

O=c1[nH]cc(C=Nc2ccccc2)c(=O)[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1[nH]cc(C=Nc2ccccc2)c(=O)[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 46 of 46 chemicals

4-{[(2,4,6-Trioxotetrahydro-5(2H)-pyrimidinylidene)methyl]amino}benzenesulfonamide chemical structure, C11H10N4O5S, CAS 5628-20-6
4-{[(2,4,6-Trioxotetrahydro-5(2H)-pyrimidinylidene)methyl]amino}benzenesulfonamide
CAS 5628-20-6C11H10N4O5S
4-{[(2,4,6-Trioxotetrahydropyrimidin-5(2H)-ylidene)methyl]amino}benzoic acid chemical structure, C12H9N3O5, CAS 338989-14-3
4-{[(2,4,6-Trioxotetrahydropyrimidin-5(2H)-ylidene)methyl]amino}benzoic acid
CAS 338989-14-3C12H9N3O5
5-[(3-Nitroanilino)methylene]barbituric acid chemical structure, C11H8N4O5, CAS 200626-88-6
5-[(3-Nitroanilino)methylene]barbituric acid
CAS 200626-88-6C11H8N4O5
5-[(2,5-Dichloroanilino)methylene]-1,3-diethyl-2,4,6(1H,3H,5H)-pyrimidinetrione chemical structure, C15H15Cl2N3O3, CAS 353278-60-1
5-[(2,5-Dichloroanilino)methylene]-1,3-diethyl-2,4,6(1H,3H,5H)-pyrimidinetrione
CAS 353278-60-1C15H15Cl2N3O3
Methyl 4-{[(1,3-dimethyl-2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)methyl]amino}benzoate chemical structure, C15H15N3O5, CAS 205809-92-3
Methyl 4-{[(1,3-dimethyl-2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)methyl]amino}benzoate
CAS 205809-92-3C15H15N3O5
1,3-Dimethyl-5-{[(4-methylphenyl)amino]methylidene}-1,3-diazinane-2,4,6-trione chemical structure, C14H15N3O3, CAS 181648-71-5
1,3-Dimethyl-5-{[(4-methylphenyl)amino]methylidene}-1,3-diazinane-2,4,6-trione
CAS 181648-71-5C14H15N3O3
5-((3-Hydroxyanilino)methylene)-2,4,6(1H,3H,5H)-pyrimidinetrione chemical structure, C11H9N3O4, CAS 325697-58-3
5-((3-Hydroxyanilino)methylene)-2,4,6(1H,3H,5H)-pyrimidinetrione
CAS 325697-58-3C11H9N3O4
5-(Anilinomethylene)barbituric acid chemical structure, C11H9N3O3, CAS 23069-91-2
5-(Anilinomethylene)barbituric acid
CAS 23069-91-2C11H9N3O3
5-{[(3-Fluorophenyl)amino]methylidene}pyrimidine-2,4,6(1H,3H,5H)-trione chemical structure, C11H8FN3O3, CAS 337502-96-2
5-{[(3-Fluorophenyl)amino]methylidene}pyrimidine-2,4,6(1H,3H,5H)-trione
CAS 337502-96-2C11H8FN3O3
5-[(3-Chloro-4-fluoro-phenylamino)-methylene]-pyrimidine-2,4,6-trione chemical structure, C11H7ClFN3O3, CAS 310456-96-3
5-[(3-Chloro-4-fluoro-phenylamino)-methylene]-pyrimidine-2,4,6-trione
CAS 310456-96-3C11H7ClFN3O3
5-{[(5-Chloro-2-methoxyphenyl)amino]methylidene}-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione chemical structure, C14H14ClN3O4, CAS 372500-58-8
5-{[(5-Chloro-2-methoxyphenyl)amino]methylidene}-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione
CAS 372500-58-8C14H14ClN3O4
5-(((3,5-Dimethoxyphenyl)amino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione chemical structure, C13H13N3O5, CAS 431986-73-1
5-(((3,5-Dimethoxyphenyl)amino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione
CAS 431986-73-1C13H13N3O5
5-{[(4-Methoxyphenyl)amino]methylidene}-1,3-dimethyl-1,3-diazinane-2,4,6-trione chemical structure, C14H15N3O4, CAS 223921-80-0
5-{[(4-Methoxyphenyl)amino]methylidene}-1,3-dimethyl-1,3-diazinane-2,4,6-trione
CAS 223921-80-0C14H15N3O4
5-[(4-Chloroanilino)methylene]-1,3-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione chemical structure, C13H12ClN3O3, CAS 69791-20-4
5-[(4-Chloroanilino)methylene]-1,3-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione
CAS 69791-20-4C13H12ClN3O3
5-({[2-(Trifluoromethyl)phenyl]amino}methylidene)pyrimidine-2,4,6(1H,3H,5H)-trione chemical structure, C12H8F3N3O3, CAS 310456-94-1
5-({[2-(Trifluoromethyl)phenyl]amino}methylidene)pyrimidine-2,4,6(1H,3H,5H)-trione
CAS 310456-94-1C12H8F3N3O3
Ethyl 4-{[(Z)-(1-ethyl-2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)methyl]amino}benzoate chemical structure, C16H17N3O5, CAS 690674-61-4
Ethyl 4-{[(Z)-(1-ethyl-2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)methyl]amino}benzoate
CAS 690674-61-4C16H17N3O5
1,3-Dimethyl-5-{[3-(trifluoromethyl)anilino]methylene}-2,4,6(1H,3H,5H)-pyrimidinetrione chemical structure, C14H12F3N3O3, CAS 297137-68-9
1,3-Dimethyl-5-{[3-(trifluoromethyl)anilino]methylene}-2,4,6(1H,3H,5H)-pyrimidinetrione
CAS 297137-68-9C14H12F3N3O3
5-(Anilinomethylene)-1,3-dimethylbarbituric acid chemical structure, C13H13N3O3, CAS 23069-97-8
5-(Anilinomethylene)-1,3-dimethylbarbituric acid
CAS 23069-97-8C13H13N3O3
4-[[(1,3-Dimethyl-2,4,6-trioxo-1,3-diazinan-5-ylidene)methyl]amino]benzoic acid chemical structure, C14H13N3O5, CAS 221661-98-9
4-[[(1,3-Dimethyl-2,4,6-trioxo-1,3-diazinan-5-ylidene)methyl]amino]benzoic acid
CAS 221661-98-9C14H13N3O5
2-{[(2,4,6-Trioxo-1,3-diazinan-5-ylidene)methyl]amino}benzoic acid chemical structure, C12H9N3O5, CAS 382173-94-6
2-{[(2,4,6-Trioxo-1,3-diazinan-5-ylidene)methyl]amino}benzoic acid
CAS 382173-94-6C12H9N3O5
5-{[(2,6-Dimethylphenyl)amino]methylene}-1,3-dihydropyrimidine-2,4,6-trione chemical structure, C13H13N3O3, CAS 254991-12-3
5-{[(2,6-Dimethylphenyl)amino]methylene}-1,3-dihydropyrimidine-2,4,6-trione
CAS 254991-12-3C13H13N3O3
5-[(2,4-Dichloroanilino)methylidene]-1,3-diazinane-2,4,6-trione chemical structure, C11H7Cl2N3O3, CAS 254109-10-9
5-[(2,4-Dichloroanilino)methylidene]-1,3-diazinane-2,4,6-trione
CAS 254109-10-9C11H7Cl2N3O3
5-((4-Chloroanilino)methylene)-2,4,6(1H,3H,5H)-pyrimidinetrione chemical structure, C11H8ClN3O3, CAS 23872-55-1
5-((4-Chloroanilino)methylene)-2,4,6(1H,3H,5H)-pyrimidinetrione
CAS 23872-55-1C11H8ClN3O3
5-[(3-Chloroanilino)methylidene]-1,3-diazinane-2,4,6-trione chemical structure, C11H8ClN3O3, CAS 392694-09-6
5-[(3-Chloroanilino)methylidene]-1,3-diazinane-2,4,6-trione
CAS 392694-09-6C11H8ClN3O3