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Murcko scaffold

Ring system with 4 rings and 21 atoms

12 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 21
Chemicals: 12
With full pages: 1

Scaffold SMILES

O=C(c1cc2ccccc2s1)N1CCCc2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(c1cc2ccccc2s1)N1CCCc2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

(3-Chloro-6-methyl-1-benzothiophen-2-yl)(6-fluoro-2-methyl-3,4-dihydroquinolin-1(2H)-yl)methanone chemical structure, C20H17ClFNOS, CAS 303135-72-0

(3-Chloro-6-methyl-1-benzothiophen-2-yl)(6-fluoro-2-methyl-3,4-dihydroquinolin-1(2H)-yl)methanone

CAS 303135-72-0C₂₀H₁₇ClFNOS

(3-Chlorobenzo[b]thiophen-2-yl)(3,4-dihydroquinolin-1(2H)-yl)methanone chemical structure, C18H14ClNOS, CAS 216501-54-1

(3-Chlorobenzo[b]thiophen-2-yl)(3,4-dihydroquinolin-1(2H)-yl)methanone

CAS 216501-54-1C₁₈H₁₄ClNOS

(3,4-Dichloro-1-benzothiophen-2-yl)-(3,4-dihydro-2H-quinolin-1-yl)methanone chemical structure, C18H13Cl2NOS, CAS 445016-39-7

(3,4-Dichloro-1-benzothiophen-2-yl)-(3,4-dihydro-2H-quinolin-1-yl)methanone

CAS 445016-39-7C₁₈H₁₃Cl₂NOS

(3,6-Dichlorobenzo[b]thiophen-2-yl)(3,4-dihydroquinolin-1(2H)-yl)methanone chemical structure, C18H13Cl2NOS, CAS 332156-29-3

(3,6-Dichlorobenzo[b]thiophen-2-yl)(3,4-dihydroquinolin-1(2H)-yl)methanone

CAS 332156-29-3C₁₈H₁₃Cl₂NOS

(3-Chloro-1-benzothiophen-2-yl)-(6-methoxy-3,4-dihydro-2H-quinolin-1-yl)methanone chemical structure, C19H16ClNO2S, CAS 216501-60-9

(3-Chloro-1-benzothiophen-2-yl)-(6-methoxy-3,4-dihydro-2H-quinolin-1-yl)methanone

CAS 216501-60-9C₁₉H₁₆ClNO₂S

(3-Chloro-6-nitro-1-benzothiophen-2-yl)-(6-methoxy-2,2,4-trimethyl-3,4-dihydroquinolin-1-yl)methanone chemical structure, C22H21ClN2O4S, CAS 314039-83-3

(3-Chloro-6-nitro-1-benzothiophen-2-yl)-(6-methoxy-2,2,4-trimethyl-3,4-dihydroquinolin-1-yl)methanone

CAS 314039-83-3C₂₂H₂₁ClN₂O₄S

1-[(3-Chloro-1-benzothien-2-yl)carbonyl]-2,2,4,7-tetramethyl-1,2,3,4-tetrahydroquinoline chemical structure, C22H22ClNOS, CAS 371945-62-9

1-[(3-Chloro-1-benzothien-2-yl)carbonyl]-2,2,4,7-tetramethyl-1,2,3,4-tetrahydroquinoline

CAS 371945-62-9C₂₂H₂₂ClNOS

(3-Chloro-1-benzothiophen-2-yl)(6-methoxy-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)methanone chemical structure, C22H22ClNO2S, CAS 332144-16-8

(3-Chloro-1-benzothiophen-2-yl)(6-methoxy-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)methanone

CAS 332144-16-8C₂₂H₂₂ClNO₂S

(3-Chloro-1-benzothiophen-2-yl)-(2,2,4-trimethyl-3,4-dihydroquinolin-1-yl)methanone chemical structure, C21H20ClNOS, CAS 332144-17-9

(3-Chloro-1-benzothiophen-2-yl)-(2,2,4-trimethyl-3,4-dihydroquinolin-1-yl)methanone

CAS 332144-17-9C₂₁H₂₀ClNOS

(3-Chloro-1-benzothiophen-2-yl)(2,2,4,6-tetramethyl-3,4-dihydroquinolin-1(2H)-yl)methanone chemical structure, C22H22ClNOS, CAS 371953-85-4

(3-Chloro-1-benzothiophen-2-yl)(2,2,4,6-tetramethyl-3,4-dihydroquinolin-1(2H)-yl)methanone

CAS 371953-85-4C₂₂H₂₂ClNOS

(3-Chloro-1-benzothiophen-2-yl)(2,2,4,6,7-pentamethyl-3,4-dihydroquinolin-1(2H)-yl)methanone chemical structure, C23H24ClNOS, CAS 371220-82-5

(3-Chloro-1-benzothiophen-2-yl)(2,2,4,6,7-pentamethyl-3,4-dihydroquinolin-1(2H)-yl)methanone

CAS 371220-82-5C₂₃H₂₄ClNOS

(3-Chloro-1-benzothiophen-2-yl)(7-methoxy-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)methanone chemical structure, C22H22ClNO2S, CAS 810627-12-4

(3-Chloro-1-benzothiophen-2-yl)(7-methoxy-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)methanone

CAS 810627-12-4C₂₂H₂₂ClNO₂S