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Murcko scaffold

Benzo-12-crown-4 scaffold

22 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
16
Chemicals
22
With full pages
7
Scaffold SMILES

c1ccc2c(c1)OCCOCCOCCO2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Benzo-12-crown-4 page
Murcko scaffold c1ccc2c(c1)OCCOCCOCCO2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 22 of 22 chemicals

N-(2,5,8,11-Tetraoxabicyclo[10.4.0]hexadeca-1(12),13,15-trien-14-yl)prop-2-enamide chemical structure, C15H19NO5, CAS 84488-73-3
N-(2,5,8,11-Tetraoxabicyclo[10.4.0]hexadeca-1(12),13,15-trien-14-yl)prop-2-enamide
CAS 84488-73-3C15H19NO5
12-Amino-13-bromo-benzo-12-crown-4 chemical structure, C12H16BrNO4, CAS 959260-93-6
12-Amino-13-bromo-benzo-12-crown-4
CAS 959260-93-6C12H16BrNO4
Benzo-12-crown-4 chemical structure, C12H16O4, CAS 14174-08-4
Benzo-12-crown-4
CAS 14174-08-4C12H16O4
4'-Nitrobenzo-12-crown-4 chemical structure, C12H15NO6, CAS 78554-67-3
4'-Nitrobenzo-12-crown-4
CAS 78554-67-3C12H15NO6
1-(6,7,9,10,12,13-Hexahydro-5,8,11,14-tetraoxa-benzocyclododecen-2-yl)-ethanone chemical structure, C14H18O5, CAS 107996-83-8
1-(6,7,9,10,12,13-Hexahydro-5,8,11,14-tetraoxa-benzocyclododecen-2-yl)-ethanone
CAS 107996-83-8C14H18O5
2,5,8,11-Tetraoxabicyclo[10.4.0]hexadeca-1(12),13,15-triene-14-carboxylic acid chemical structure, C13H16O6, CAS 170031-43-3
2,5,8,11-Tetraoxabicyclo[10.4.0]hexadeca-1(12),13,15-triene-14-carboxylic acid
CAS 170031-43-3C13H16O6
2,3,5,6,8,9-Hexahydro-1,4,7,10-benzotetraoxacyclododecine-12-carbaldehyde chemical structure, C13H16O5, CAS 84993-16-8
2,3,5,6,8,9-Hexahydro-1,4,7,10-benzotetraoxacyclododecine-12-carbaldehyde
CAS 84993-16-8C13H16O5
2,3,5,6,8,9-Hexahydro-1,4,7,10-benzotetraoxacyclododecin-12-amine chemical structure, C12H17NO4, CAS 78554-68-4
2,3,5,6,8,9-Hexahydro-1,4,7,10-benzotetraoxacyclododecin-12-amine
CAS 78554-68-4C12H17NO4
2-Methyl-N-(2,5,8,11-tetraoxabicyclo[10.4.0]hexadeca-1(12),13,15-trien-14-yl)-2-propenamide chemical structure, C16H21NO5, CAS 488734-89-0
2-Methyl-N-(2,5,8,11-tetraoxabicyclo[10.4.0]hexadeca-1(12),13,15-trien-14-yl)-2-propenamide
CAS 488734-89-0C16H21NO5
12,13-Dibromo-2,3,5,6,8,9-hexahydro-1,4,7,10-benzotetraoxacyclododecine chemical structure, C12H14Br2O4, CAS 172792-52-8
12,13-Dibromo-2,3,5,6,8,9-hexahydro-1,4,7,10-benzotetraoxacyclododecine
CAS 172792-52-8C12H14Br2O4
1,4,7,10-Benzotetraoxacyclododecin, 12-bromo-2,3,5,6,8,9-hexahydro- chemical structure, C12H15BrO4, CAS 118409-81-7
1,4,7,10-Benzotetraoxacyclododecin, 12-bromo-2,3,5,6,8,9-hexahydro-
CAS 118409-81-7C12H15BrO4
1,4,7,10-Benzotetraoxacyclododecin, 12-ethenyl-2,3,5,6,8,9-hexahydro- chemical structure, C14H18O4, CAS 109789-52-8
1,4,7,10-Benzotetraoxacyclododecin, 12-ethenyl-2,3,5,6,8,9-hexahydro-
CAS 109789-52-8C14H18O4
Methyl 2,3,5,6,8,9-hexahydro-1,4,7,10-benzotetraoxacyclododecin-12-carboxylate chemical structure, C14H18O6, CAS 860630-18-8
Methyl 2,3,5,6,8,9-hexahydro-1,4,7,10-benzotetraoxacyclododecin-12-carboxylate
CAS 860630-18-8C14H18O6
14-Ethynyl-2,5,8,11-tetraoxabicyclo[10.4.0]hexadeca-1(12),13,15-triene chemical structure, C14H16O4, CAS 92710-96-8
14-Ethynyl-2,5,8,11-tetraoxabicyclo[10.4.0]hexadeca-1(12),13,15-triene
CAS 92710-96-8C14H16O4
Ethyl 13-amino-2,3,5,6,8,9-hexahydrobenzo[b][1,4,7,10]tetraoxacyclododecine-12-carboxylate hydrochloride chemical structure, C15H22ClNO6, CAS 1204313-56-3
Ethyl 13-amino-2,3,5,6,8,9-hexahydrobenzo[b][1,4,7,10]tetraoxacyclododecine-12-carboxylate hydrochloride
CAS 1204313-56-3C15H22ClNO6
Ethyl 13-amino-2,3,5,6,8,9-hexahydro-1,4,7,10-benzotetraoxacyclododecine-12-carboxylate chemical structure, C15H21NO6, CAS 1204386-13-9
Ethyl 13-amino-2,3,5,6,8,9-hexahydro-1,4,7,10-benzotetraoxacyclododecine-12-carboxylate
CAS 1204386-13-9C15H21NO6
Ethyl 2,3,5,6,8,9-hexahydro-13-nitro-1,4,7,10-benzotetraoxacyclododecin-12-carboxylate chemical structure, C15H19NO8, CAS 1204313-55-2
Ethyl 2,3,5,6,8,9-hexahydro-13-nitro-1,4,7,10-benzotetraoxacyclododecin-12-carboxylate
CAS 1204313-55-2C15H19NO8
Ethyl 2,3,5,6,8,9-hexahydrobenzo[B][1,4,7,10]tetraoxacyclododecine-12-carboxylate chemical structure, C15H20O6, CAS 180475-66-5
Ethyl 2,3,5,6,8,9-hexahydrobenzo[B][1,4,7,10]tetraoxacyclododecine-12-carboxylate
CAS 180475-66-5C15H20O6
Methyl 13-nitro-2,3,5,6,8,9-hexahydrobenzo[b][1,4,7,10]tetraoxacyclododecine-12-carboxylate chemical structure, C14H17NO8, CAS 1403772-23-5
Methyl 13-nitro-2,3,5,6,8,9-hexahydrobenzo[b][1,4,7,10]tetraoxacyclododecine-12-carboxylate
CAS 1403772-23-5C14H17NO8
(2,3,5,6,8,9-Hexahydrobenzo[b][1,4,7,10]tetraoxacyclododecin-12-yl)methanol chemical structure, C13H18O5, CAS 1326319-07-6
(2,3,5,6,8,9-Hexahydrobenzo[b][1,4,7,10]tetraoxacyclododecin-12-yl)methanol
CAS 1326319-07-6C13H18O5
2,3,5,6,8,9-Hexahydrobenzo[b][1,4,7,10]tetraoxacyclododecine-11,14-dicarboxylic acid chemical structure, C14H16O8, CAS 1863934-88-6
2,3,5,6,8,9-Hexahydrobenzo[b][1,4,7,10]tetraoxacyclododecine-11,14-dicarboxylic acid
CAS 1863934-88-6C14H16O8
2,3,5,6,8,9-Hexahydrobenzo[B][1,4,7,10]tetraoxacyclododecine-11,14-dicarbaldehyde chemical structure, C14H16O6, CAS 1872410-57-5
2,3,5,6,8,9-Hexahydrobenzo[B][1,4,7,10]tetraoxacyclododecine-11,14-dicarbaldehyde
CAS 1872410-57-5C14H16O6