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Murcko scaffold

Ring system with 2 rings and 15 atoms

22 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
15
Chemicals
22
With full pages
3
Scaffold SMILES

O=C(c1ccccc1)c1ccc(=O)[nH]c1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1ccccc1)c1ccc(=O)[nH]c1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 22 of 22 chemicals

5-(2-Hydroxybenzoyl)-2-oxo-1H-pyridine-3-carboxamide chemical structure, C13H10N2O4, CAS 53390-23-1
5-(2-Hydroxybenzoyl)-2-oxo-1H-pyridine-3-carboxamide
CAS 53390-23-1C13H10N2O4
5-(5-Ethyl-2-hydroxybenzoyl)-2-oxo-1H-pyridine-3-carboxamide chemical structure, C15H14N2O4, CAS 53390-22-0
5-(5-Ethyl-2-hydroxybenzoyl)-2-oxo-1H-pyridine-3-carboxamide
CAS 53390-22-0C15H14N2O4
5-(5-Fluoro-2-hydroxybenzoyl)-1-(2-methoxyethyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile chemical structure, C16H13FN2O4, CAS 743444-70-4
5-(5-Fluoro-2-hydroxybenzoyl)-1-(2-methoxyethyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile
CAS 743444-70-4C16H13FN2O4
5-(5-Fluoro-2-hydroxybenzoyl)-2-oxo-1-(propan-2-yl)-1,2-dihydropyridine-3-carbonitrile chemical structure, C16H13FN2O3, CAS 743444-77-1
5-(5-Fluoro-2-hydroxybenzoyl)-2-oxo-1-(propan-2-yl)-1,2-dihydropyridine-3-carbonitrile
CAS 743444-77-1C16H13FN2O3
5-(5-Fluoro-2-hydroxybenzoyl)-1-(3-methoxypropyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile chemical structure, C17H15FN2O4, CAS 743444-86-2
5-(5-Fluoro-2-hydroxybenzoyl)-1-(3-methoxypropyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile
CAS 743444-86-2C17H15FN2O4
5-(5-Fluoro-2-hydroxybenzoyl)-1,2-dihydro-1-methyl-2-oxo-3-pyridinecarbonitrile chemical structure, C14H9FN2O3, CAS 750599-07-6
5-(5-Fluoro-2-hydroxybenzoyl)-1,2-dihydro-1-methyl-2-oxo-3-pyridinecarbonitrile
CAS 750599-07-6C14H9FN2O3
5-(5-Fluoro-2-hydroxybenzoyl)-2-oxo-1-(prop-2-en-1-yl)-1,2-dihydropyridine-3-carbonitrile chemical structure, C16H11FN2O3, CAS 737820-09-6
5-(5-Fluoro-2-hydroxybenzoyl)-2-oxo-1-(prop-2-en-1-yl)-1,2-dihydropyridine-3-carbonitrile
CAS 737820-09-6C16H11FN2O3
5-(2-Hydroxybenzoyl)-2-oxo-1-(propan-2-yl)-1,2-dihydropyridine-3-carbonitrile chemical structure, C16H14N2O3, CAS 730950-26-2
5-(2-Hydroxybenzoyl)-2-oxo-1-(propan-2-yl)-1,2-dihydropyridine-3-carbonitrile
CAS 730950-26-2C16H14N2O3
5-(2-Hydroxybenzoyl)-1-(2-methoxyethyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile chemical structure, C16H14N2O4, CAS 730951-39-0
5-(2-Hydroxybenzoyl)-1-(2-methoxyethyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile
CAS 730951-39-0C16H14N2O4
5-(2-Hydroxy-5-methoxybenzoyl)-1-(3-methoxypropyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile chemical structure, C18H18N2O5, CAS 726146-05-0
5-(2-Hydroxy-5-methoxybenzoyl)-1-(3-methoxypropyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile
CAS 726146-05-0C18H18N2O5
5-(5-Fluoro-2-hydroxybenzoyl)-2-oxo-1-propyl-1,2-dihydropyridine-3-carbonitrile chemical structure, C16H13FN2O3, CAS 851169-37-4
5-(5-Fluoro-2-hydroxybenzoyl)-2-oxo-1-propyl-1,2-dihydropyridine-3-carbonitrile
CAS 851169-37-4C16H13FN2O3
5-(2-Hydroxybenzoyl)-1-(3-methoxypropyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile chemical structure, C17H16N2O4, CAS 731011-89-5
5-(2-Hydroxybenzoyl)-1-(3-methoxypropyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile
CAS 731011-89-5C17H16N2O4
5-Benzoyl-6-methylpyridin-2(1H)-one chemical structure, C13H11NO2, CAS 102252-88-0
5-Benzoyl-6-methylpyridin-2(1H)-one
CAS 102252-88-0C13H11NO2
Ethyl 1-methyl-6-(methylsulfanyl)-2-oxo-5-(phenylcarbonyl)-1,2-dihydropyridine-3-carboxylate chemical structure, C17H17NO4S, CAS 1015603-47-0
Ethyl 1-methyl-6-(methylsulfanyl)-2-oxo-5-(phenylcarbonyl)-1,2-dihydropyridine-3-carboxylate
CAS 1015603-47-0C17H17NO4S
1-Butyl-5-(5-fluoro-2-hydroxybenzoyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile chemical structure, C17H15FN2O3, CAS 1087634-93-2
1-Butyl-5-(5-fluoro-2-hydroxybenzoyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile
CAS 1087634-93-2C17H15FN2O3
5-Benzoyl-6-(ethylsulfanyl)-1-methylpyridin-2(1H)-one chemical structure, C15H15NO2S, CAS 602309-16-0
5-Benzoyl-6-(ethylsulfanyl)-1-methylpyridin-2(1H)-one
CAS 602309-16-0C15H15NO2S
5-(3,5-Dichloro-2-hydroxybenzoyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile chemical structure, C13H6Cl2N2O3, CAS 1424940-61-3
5-(3,5-Dichloro-2-hydroxybenzoyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile
CAS 1424940-61-3C13H6Cl2N2O3
3-Cyano-5-(2-fluorosulfonyloxybenzoyl)-1-(2-methoxyethyl)-2-oxopyridine chemical structure, C16H13FN2O6S, CAS 2411286-10-5
3-Cyano-5-(2-fluorosulfonyloxybenzoyl)-1-(2-methoxyethyl)-2-oxopyridine
CAS 2411286-10-5C16H13FN2O6S
3-Cyano-5-(2-fluorosulfonyloxy-5-methoxybenzoyl)-1-(3-methoxypropyl)-2-oxopyridine chemical structure, C18H17FN2O7S, CAS 2411240-92-9
3-Cyano-5-(2-fluorosulfonyloxy-5-methoxybenzoyl)-1-(3-methoxypropyl)-2-oxopyridine
CAS 2411240-92-9C18H17FN2O7S
3-Cyano-5-(5-fluoro-2-fluorosulfonyloxybenzoyl)-1-methyl-2-oxopyridine chemical structure, C14H8F2N2O5S, CAS 2411238-90-7
3-Cyano-5-(5-fluoro-2-fluorosulfonyloxybenzoyl)-1-methyl-2-oxopyridine
CAS 2411238-90-7C14H8F2N2O5S
Orb1688325 chemical structure, C18H18N4O6
Orb1688325
C18H18N4O6
Cox-1/2-IN-3 chemical structure, C14H8N2O8, CAS 2428387-82-8
Cox-1/2-IN-3
CAS 2428387-82-8C14H8N2O8