Murcko scaffold
1-(Benzenesulfonyl)piperazine scaffold
1,230 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 15
- Chemicals
- 1,230
- With full pages
- 195
Scaffold SMILES
O=S(=O)(c1ccccc1)N1CCNCC1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 1,230 chemicals
1-Methyl-4-(phenylsulfonyl)piperazine
CAS 66739-87-5C11H16N2O2S
1-Methyl-4-(para-tolylsulfonyl)-piperazine
CAS 46779-48-0C12H18N2O2S
4-(Benzenesulfonyl)piperazine-1-carbaldehyde
CAS 500859-71-2C11H14N2O3S
RefChem:381286
CAS 309271-25-8C13H18N2O3S
4-(4-Methylpiperazine-1-sulfonyl)aniline
CAS 21623-68-7C11H17N3O2S
3-(4-Methanesulfonyl-piperazine-1-sulfonyl)-benzoic acid
CAS 385379-94-2C12H16N2O6S2
1-(4-Chloro-3-methoxy-benzenesulfonyl)-4-methyl-piperazine
CAS 457961-49-8C12H17ClN2O3S
Ethyl 4-(2,4,6-trimethylbenzenesulfonyl)piperazine-1-carboxylate
CAS 349402-58-0C16H24N2O4S
![1-[4-(4-Fluorophenyl)sulfonylpiperazin-1-yl]-3-methylbutan-1-one chemical structure, C15H21FN2O3S, CAS 497229-32-0](/s/IUGHMLAUKKHWSL-UHFFFAOYSA-N.svg)
1-[4-(4-Fluorophenyl)sulfonylpiperazin-1-yl]-3-methylbutan-1-one
CAS 497229-32-0C15H21FN2O3S
1-(5-Isopropyl-2-methoxy-4-methyl-benzenesulfonyl)-4-methyl-piperazine
CAS 332389-07-8C16H26N2O3S
Ethyl 4-((2,5-dichlorophenyl)sulfonyl)piperazinecarboxylate
CAS 349403-05-0C13H16Cl2N2O4S
1-((5-Isopropyl-2-methoxyphenyl)sulfonyl)-4-methylpiperazine
CAS 723743-29-1C15H24N2O3S
4-(Benzenesulfonyl)-N,N-dimethylpiperazine-1-sulfonamide
CAS 801225-05-8C12H19N3O4S2
Ethyl 4-(4-fluorophenyl)sulfonylpiperazine-1-carboxylate
CAS 16017-51-9C13H17FN2O4S
![1-[(4-Bromo-2,5-dimethoxyphenyl)sulfonyl]-4-methylpiperazine chemical structure, C13H19BrN2O4S, CAS 409357-78-4](/s/ORLLIGQIIJQOON-UHFFFAOYSA-N.svg)
1-[(4-Bromo-2,5-dimethoxyphenyl)sulfonyl]-4-methylpiperazine
CAS 409357-78-4C13H19BrN2O4S
2-(4-(Phenylsulfonyl)piperazin-1-yl)ethanol
CAS 16017-63-3C12H18N2O3S
2-(4-((4-Methoxyphenyl)sulfonyl)piperazin-1-yl)ethanol
CAS 321531-40-2C13H20N2O4S
![1-[(4-Methoxyphenyl)sulfonyl]-4-methylpiperazine chemical structure, C12H18N2O3S, CAS 304668-35-7](/s/WLKJUMSIGXLLAS-UHFFFAOYSA-N.svg)
1-[(4-Methoxyphenyl)sulfonyl]-4-methylpiperazine
CAS 304668-35-7C12H18N2O3S
![2-[4-(4-Nitrophenyl)sulfonylpiperazin-1-yl]ethanol chemical structure, C12H17N3O5S, CAS 331845-74-0](/s/RNYAOMARGHUJPJ-UHFFFAOYSA-N.svg)
2-[4-(4-Nitrophenyl)sulfonylpiperazin-1-yl]ethanol
CAS 331845-74-0C12H17N3O5S
1-(3-Chloro-4-fluorophenylsulfonyl)-4-methylpiperazine
CAS 613657-40-2C11H14ClFN2O2S
![1-Methyl-4-[[2-(trifluoromethyl)phenyl]sulfonyl]piperazine chemical structure, C12H15F3N2O2S, CAS 613658-02-9](/s/UBONSUREFARGMA-UHFFFAOYSA-N.svg)
1-Methyl-4-[[2-(trifluoromethyl)phenyl]sulfonyl]piperazine
CAS 613658-02-9C12H15F3N2O2S
1-((2,6-Dichlorophenyl)sulfonyl)-4-ethylpiperazine
CAS 612042-85-0C12H16Cl2N2O2S
1-Ethyl-4-(4-methoxy-2,5-dimethylphenyl)sulfonylpiperazine
CAS 692763-11-4C15H24N2O3S
Methyl (4-((4-methylpiperazin-1-yl)sulfonyl)phenyl)carbamate
CAS 301683-50-1C13H19N3O4S
- 1-Methyl-4-[(2,3,4-trichlorophenyl)sulfonyl]piperazine325813-36-3C11H13Cl3N2O2S
- 4 suppliers1-(4-Methylbenzenesulfonyl)piperazine27106-51-0C11H16N2O2S
- Piperazine-1-carboxylic acid, 4-(2-methoxy-5-methylbenzenesulfonyl)-, ethyl ester681852-57-3C15H22N2O5S
- 1 suppliers1-(4-Bromophenylsulfonyl)-4-methylpiperazine837-12-7C11H15BrN2O2S
- 1-(Benzenesulfonyl)-4-propan-2-ylpiperazine100800-52-0C13H20N2O2S
- Ethyl 4-[(2,4,5-trimethylphenyl)sulfonyl]piperazine-1-carboxylate681837-75-2C16H24N2O4S
- 1 suppliers1-(4-Bromobenzene-1-sulfonyl)piperazine179334-20-4C10H13BrN2O2S
- 1-[4-(Benzenesulfonyl)piperazin-1-yl]-3-methylbutan-1-one333756-34-6C15H22N2O3S
- 1-[4-(4-Methoxyphenyl)sulfonylpiperazin-1-yl]-3-methylbutan-1-one333756-74-4C16H24N2O4S
- 1-[4-(4-Chlorophenyl)sulfonylpiperazin-1-yl]-3-methylbutan-1-one333756-83-5C15H21ClN2O3S
- 1-(Methylsulfonyl)-4-[(2-nitrophenyl)sulfonyl]piperazine428839-29-6C11H15N3O6S2
- 1-Methylsulfonyl-4-(4-nitrophenyl)sulfonylpiperazine428837-53-0C11H15N3O6S2
- 1-(Ethylsulfonyl)-4-[(4-fluorophenyl)sulfonyl]piperazine441745-90-0C12H17FN2O4S2
- 1-Ethylsulfonyl-4-(4-methylphenyl)sulfonylpiperazine428839-12-7C13H20N2O4S2
- 1-[(4-Fluorophenyl)sulfonyl]-4-(methylsulfonyl)piperazine428834-75-7C11H15FN2O4S2
- 1-(Phenylsulfonyl)-4-(propylsulfonyl)piperazine428839-97-8C13H20N2O4S2
- 1-[(4-Methylphenyl)sulfonyl]-4-(propylsulfonyl)piperazine428844-76-2C14H22N2O4S2
- Ethyl 4-[(4-methylphenyl)sulfonyl]-1-piperazinecarboxylate27106-47-4C14H20N2O4S
- Ethyl 4-(benzenesulfonyl)piperazine-1-carboxylate27106-46-3C13H18N2O4S
- 1-(4-Chloro-2,5-dimethoxyphenyl)sulfonyl-4-methylpiperazine312526-16-2C13H19ClN2O4S
- Ethyl 4-[(4-chlorophenyl)sulfonyl]-1-piperazinecarboxylate16017-52-0C13H17ClN2O4S
- Ethyl 4-(4-nitrophenyl)sulfonylpiperazine-1-carboxylate64268-92-4C13H17N3O6S
- Ethyl 4-(2-nitrobenzenesulfonyl)piperazine-1-carboxylate349099-38-3C13H17N3O6S
- 1-((2-Methoxy-5-methylphenyl)sulfonyl)-4-methylpiperazine325991-91-1C13H20N2O3S
Related scaffolds
Same ring framework with different atoms or bond orders
c1ccc(Cc2ccccc2)cc1952 chemicals
c1ccc(Oc2ccccc2)cc1933 chemicals
O=C(c1ccccc1)c1ccccc1537 chemicals
c1ccc(Nc2ccccc2)cc1395 chemicals
c1ccc(CN2CCCCC2)cc1283 chemicals
c1ccc(CN2CCNCC2)cc1267 chemicals
O=S(=O)(c1ccccc1)N1CCCCC1266 chemicals
c1ccc(Oc2ccccn2)cc1238 chemicals
c1ccc(Sc2ccccc2)cc1195 chemicals
c1ccc(OC2CCCCO2)cc1164 chemicals
O=C(c1ccccc1)N1CCCCC1164 chemicals
O=S(=O)(c1ccccc1)N1CCOCC1148 chemicals