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Murcko scaffold

Ring system with 2 rings and 20 atoms

22 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
20
Chemicals
22
With full pages
17
Scaffold SMILES

O=C(CNC(=O)c1ccccc1)NN=Cc1cccs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CNC(=O)c1ccccc1)NN=Cc1cccs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 22 of 22 chemicals

2-Fluoro-N-[2-oxo-2-[(2E)-2-(thiophen-2-ylmethylidene)hydrazinyl]ethyl]benzamide chemical structure, C14H12FN3O2S, CAS 374617-18-2
2-Fluoro-N-[2-oxo-2-[(2E)-2-(thiophen-2-ylmethylidene)hydrazinyl]ethyl]benzamide
CAS 374617-18-2C14H12FN3O2S
(E)-4-(tert-Butyl)-N-(2-oxo-2-(2-(thiophen-2-ylmethylene)hydrazinyl)ethyl)benzamide chemical structure, C18H21N3O2S, CAS 391877-87-5
(E)-4-(tert-Butyl)-N-(2-oxo-2-(2-(thiophen-2-ylmethylene)hydrazinyl)ethyl)benzamide
CAS 391877-87-5C18H21N3O2S
3,4-Dimethoxy-N-(2-oxo-2-(2-(2-thienylmethylene)hydrazino)ethyl)benzamide chemical structure, C16H17N3O4S, CAS 374606-62-9
3,4-Dimethoxy-N-(2-oxo-2-(2-(2-thienylmethylene)hydrazino)ethyl)benzamide
CAS 374606-62-9C16H17N3O4S
(E)-2,5-Dichloro-N-(2-oxo-2-(2-(thiophen-2-ylmethylene)hydrazinyl)ethyl)benzamide chemical structure, C14H11Cl2N3O2S, CAS 391878-49-2
(E)-2,5-Dichloro-N-(2-oxo-2-(2-(thiophen-2-ylmethylene)hydrazinyl)ethyl)benzamide
CAS 391878-49-2C14H11Cl2N3O2S
(E)-N-(2-Oxo-2-(2-(thiophen-2-ylmethylene)hydrazinyl)ethyl)-2-(trifluoromethyl)benzamide chemical structure, C15H12F3N3O2S, CAS 391878-83-4
(E)-N-(2-Oxo-2-(2-(thiophen-2-ylmethylene)hydrazinyl)ethyl)-2-(trifluoromethyl)benzamide
CAS 391878-83-4C15H12F3N3O2S
(E)-4-Methyl-N-(2-(2-((3-methylthiophen-2-yl)methylene)hydrazinyl)-2-oxoethyl)-3-nitrobenzamide chemical structure, C16H16N4O4S, CAS 391892-88-9
(E)-4-Methyl-N-(2-(2-((3-methylthiophen-2-yl)methylene)hydrazinyl)-2-oxoethyl)-3-nitrobenzamide
CAS 391892-88-9C16H16N4O4S
(E)-2-Methyl-N-(2-(2-((3-methylthiophen-2-yl)methylene)hydrazinyl)-2-oxoethyl)-3-nitrobenzamide chemical structure, C16H16N4O4S, CAS 391892-99-2
(E)-2-Methyl-N-(2-(2-((3-methylthiophen-2-yl)methylene)hydrazinyl)-2-oxoethyl)-3-nitrobenzamide
CAS 391892-99-2C16H16N4O4S
(E)-N-(2-(2-((3-Methylthiophen-2-yl)methylene)hydrazinyl)-2-oxoethyl)benzamide chemical structure, C15H15N3O2S, CAS 391891-53-5
(E)-N-(2-(2-((3-Methylthiophen-2-yl)methylene)hydrazinyl)-2-oxoethyl)benzamide
CAS 391891-53-5C15H15N3O2S
(E)-4-Butoxy-N-(2-(2-((3-methylthiophen-2-yl)methylene)hydrazinyl)-2-oxoethyl)benzamide chemical structure, C19H23N3O3S, CAS 391892-21-0
(E)-4-Butoxy-N-(2-(2-((3-methylthiophen-2-yl)methylene)hydrazinyl)-2-oxoethyl)benzamide
CAS 391892-21-0C19H23N3O3S
(E)-2-Chloro-6-fluoro-N-(2-(2-((3-methylthiophen-2-yl)methylene)hydrazinyl)-2-oxoethyl)benzamide chemical structure, C15H13ClFN3O2S, CAS 391892-55-0
(E)-2-Chloro-6-fluoro-N-(2-(2-((3-methylthiophen-2-yl)methylene)hydrazinyl)-2-oxoethyl)benzamide
CAS 391892-55-0C15H13ClFN3O2S
(E)-N-(2-(2-((3-Methylthiophen-2-yl)methylene)hydrazinyl)-2-oxoethyl)-2-(trifluoromethyl)benzamide chemical structure, C16H14F3N3O2S, CAS 391892-66-3
(E)-N-(2-(2-((3-Methylthiophen-2-yl)methylene)hydrazinyl)-2-oxoethyl)-2-(trifluoromethyl)benzamide
CAS 391892-66-3C16H14F3N3O2S
(E)-4-(N,N-Dimethylsulfamoyl)-N-(2-(2-((3-methylthiophen-2-yl)methylene)hydrazinyl)-2-oxoethyl)benzamide chemical structure, C17H20N4O4S2, CAS 391895-89-9
(E)-4-(N,N-Dimethylsulfamoyl)-N-(2-(2-((3-methylthiophen-2-yl)methylene)hydrazinyl)-2-oxoethyl)benzamide
CAS 391895-89-9C17H20N4O4S2
(E)-4-Butoxy-N-(2-oxo-2-(2-(thiophen-2-ylmethylene)hydrazinyl)ethyl)benzamide chemical structure, C18H21N3O3S, CAS 391878-18-5
(E)-4-Butoxy-N-(2-oxo-2-(2-(thiophen-2-ylmethylene)hydrazinyl)ethyl)benzamide
CAS 391878-18-5C18H21N3O3S
(E)-4-Methyl-3-nitro-N-(2-oxo-2-(2-(thiophen-2-ylmethylene)hydrazinyl)ethyl)benzamide chemical structure, C15H14N4O4S, CAS 391879-25-7
(E)-4-Methyl-3-nitro-N-(2-oxo-2-(2-(thiophen-2-ylmethylene)hydrazinyl)ethyl)benzamide
CAS 391879-25-7C15H14N4O4S
(E)-4-(N,N-Dimethylsulfamoyl)-N-(2-oxo-2-(2-(thiophen-2-ylmethylene)hydrazinyl)ethyl)benzamide chemical structure, C16H18N4O4S2, CAS 391885-09-9
(E)-4-(N,N-Dimethylsulfamoyl)-N-(2-oxo-2-(2-(thiophen-2-ylmethylene)hydrazinyl)ethyl)benzamide
CAS 391885-09-9C16H18N4O4S2
3,4,5-Triethoxy-N-({N'-[(1E)-(3-methylthiophen-2-yl)methylidene]hydrazinecarbonyl}methyl)benzamide chemical structure, C21H27N3O5S, CAS 391893-46-2
3,4,5-Triethoxy-N-({N'-[(1E)-(3-methylthiophen-2-yl)methylidene]hydrazinecarbonyl}methyl)benzamide
CAS 391893-46-2C21H27N3O5S
(E)-3,4-Dimethyl-N-(2-oxo-2-(2-(thiophen-2-ylmethylene)hydrazinyl)ethyl)benzamide chemical structure, C16H17N3O2S, CAS 391879-00-8
(E)-3,4-Dimethyl-N-(2-oxo-2-(2-(thiophen-2-ylmethylene)hydrazinyl)ethyl)benzamide
CAS 391879-00-8C16H17N3O2S
(E)-3-Methoxy-N-(2-oxo-2-(2-(thiophen-2-ylmethylene)hydrazinyl)ethyl)benzamide chemical structure, C15H15N3O3S, CAS 391878-01-6
(E)-3-Methoxy-N-(2-oxo-2-(2-(thiophen-2-ylmethylene)hydrazinyl)ethyl)benzamide
CAS 391878-01-6C15H15N3O3S
4-Methyl-N-{2-oxo-2-[(2E)-2-(2-thienylmethylene)hydrazino]ethyl}benzamide chemical structure, C15H15N3O2S, CAS 444061-69-2
4-Methyl-N-{2-oxo-2-[(2E)-2-(2-thienylmethylene)hydrazino]ethyl}benzamide
CAS 444061-69-2C15H15N3O2S
4-Fluoro-N-(2-oxo-2-(2-(2-thienylmethylene)hydrazino)ethyl)benzamide chemical structure, C14H12FN3O2S, CAS 767335-44-4
4-Fluoro-N-(2-oxo-2-(2-(2-thienylmethylene)hydrazino)ethyl)benzamide
CAS 767335-44-4C14H12FN3O2S
3,4-Dichloro-N-(2-oxo-2-(2-(2-thienylmethylene)hydrazino)ethyl)benzamide chemical structure, C14H11Cl2N3O2S, CAS 767335-32-0
3,4-Dichloro-N-(2-oxo-2-(2-(2-thienylmethylene)hydrazino)ethyl)benzamide
CAS 767335-32-0C14H11Cl2N3O2S
2-Iodo-N-(2-oxo-2-(2-(2-thienylmethylene)hydrazino)ethyl)benzamide chemical structure, C14H12IN3O2S, CAS 767314-43-2
2-Iodo-N-(2-oxo-2-(2-(2-thienylmethylene)hydrazino)ethyl)benzamide
CAS 767314-43-2C14H12IN3O2S