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Murcko scaffold

Ring system with 4 rings and 27 atoms

23 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
27
Chemicals
23
With full pages
2
Scaffold SMILES

O=C(CC1C(=O)N(CCc2ccccc2)c2ccccc21)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CC1C(=O)N(CCc2ccccc2)c2ccccc21)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 23 of 23 chemicals

3-{2-[4-(Dimethylamino)phenyl]-2-oxoethyl}-3-hydroxy-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one chemical structure, C26H26N2O3, CAS 369395-93-7
3-{2-[4-(Dimethylamino)phenyl]-2-oxoethyl}-3-hydroxy-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one
CAS 369395-93-7C26H26N2O3
3-Hydroxy-3-[2-(3-nitrophenyl)-2-oxoethyl]-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one chemical structure, C24H20N2O5, CAS 370843-47-3
3-Hydroxy-3-[2-(3-nitrophenyl)-2-oxoethyl]-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one
CAS 370843-47-3C24H20N2O5
3-[2-(4-Fluorophenyl)-2-oxoethyl]-3-hydroxy-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one chemical structure, C24H20FNO3, CAS 383892-40-8
3-[2-(4-Fluorophenyl)-2-oxoethyl]-3-hydroxy-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one
CAS 383892-40-8C24H20FNO3
3-Hydroxy-3-[2-(4-methoxy-3-nitrophenyl)-2-oxoethyl]-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one chemical structure, C25H22N2O6, CAS 421579-04-6
3-Hydroxy-3-[2-(4-methoxy-3-nitrophenyl)-2-oxoethyl]-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one
CAS 421579-04-6C25H22N2O6
3-[2-(2,4-Dimethoxyphenyl)-2-oxoethyl]-3-hydroxy-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one chemical structure, C26H25NO5, CAS 370856-18-1
3-[2-(2,4-Dimethoxyphenyl)-2-oxoethyl]-3-hydroxy-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one
CAS 370856-18-1C26H25NO5
3-Hydroxy-3-[2-(4-methylphenyl)-2-oxoethyl]-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one chemical structure, C25H23NO3, CAS 421578-94-1
3-Hydroxy-3-[2-(4-methylphenyl)-2-oxoethyl]-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one
CAS 421578-94-1C25H23NO3
3-[2-(3-Bromophenyl)-2-oxoethyl]-3-hydroxy-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one chemical structure, C24H20BrNO3, CAS 421578-99-6
3-[2-(3-Bromophenyl)-2-oxoethyl]-3-hydroxy-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one
CAS 421578-99-6C24H20BrNO3
3-[2-(4-tert-Butylphenyl)-2-oxoethyl]-3-hydroxy-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one chemical structure, C28H29NO3, CAS 421578-97-4
3-[2-(4-tert-Butylphenyl)-2-oxoethyl]-3-hydroxy-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one
CAS 421578-97-4C28H29NO3
3-[2-(3,4-Dimethoxyphenyl)-2-oxoethyl]-3-hydroxy-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one chemical structure, C26H25NO5, CAS 370844-28-3
3-[2-(3,4-Dimethoxyphenyl)-2-oxoethyl]-3-hydroxy-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one
CAS 370844-28-3C26H25NO5
3-[2-(4-Bromophenyl)-2-oxoethyl]-3-hydroxy-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one chemical structure, C24H20BrNO3, CAS 421578-98-5
3-[2-(4-Bromophenyl)-2-oxoethyl]-3-hydroxy-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one
CAS 421578-98-5C24H20BrNO3
3-[2-(4-Chlorophenyl)-2-oxoethyl]-3-hydroxy-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one chemical structure, C24H20ClNO3, CAS 369394-22-9
3-[2-(4-Chlorophenyl)-2-oxoethyl]-3-hydroxy-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one
CAS 369394-22-9C24H20ClNO3
3-[2-(3-Aminophenyl)-2-oxoethyl]-3-hydroxy-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one chemical structure, C24H22N2O3, CAS 384355-48-0
3-[2-(3-Aminophenyl)-2-oxoethyl]-3-hydroxy-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one
CAS 384355-48-0C24H22N2O3
3-Hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one chemical structure, C25H23NO4, CAS 369395-54-0
3-Hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one
CAS 369395-54-0C25H23NO4
3-Hydroxy-3-[2-(2-nitrophenyl)-2-oxoethyl]-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one chemical structure, C24H20N2O5, CAS 421579-05-7
3-Hydroxy-3-[2-(2-nitrophenyl)-2-oxoethyl]-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one
CAS 421579-05-7C24H20N2O5
3-[2-(4-Ethoxyphenyl)-2-oxoethyl]-3-hydroxy-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one chemical structure, C26H25NO4, CAS 421584-44-3
3-[2-(4-Ethoxyphenyl)-2-oxoethyl]-3-hydroxy-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one
CAS 421584-44-3C26H25NO4
3-[2-(2,5-Dimethoxyphenyl)-2-oxoethyl]-3-hydroxy-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one chemical structure, C26H25NO5, CAS 690686-29-4
3-[2-(2,5-Dimethoxyphenyl)-2-oxoethyl]-3-hydroxy-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one
CAS 690686-29-4C26H25NO5
5-Bromo-3-hydroxy-3-[2-(2-hydroxyphenyl)-2-oxoethyl]-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one chemical structure, C24H20BrNO4, CAS 690688-98-3
5-Bromo-3-hydroxy-3-[2-(2-hydroxyphenyl)-2-oxoethyl]-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one
CAS 690688-98-3C24H20BrNO4
3-Hydroxy-3-[2-(3-methoxyphenyl)-2-oxoethyl]-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one chemical structure, C25H23NO4, CAS 690697-79-1
3-Hydroxy-3-[2-(3-methoxyphenyl)-2-oxoethyl]-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one
CAS 690697-79-1C25H23NO4
3-[2-(3-Aminophenyl)-2-oxoethyl]-5-chloro-3-hydroxy-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one chemical structure, C24H21ClN2O3, CAS 690225-15-1
3-[2-(3-Aminophenyl)-2-oxoethyl]-5-chloro-3-hydroxy-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one
CAS 690225-15-1C24H21ClN2O3
3-Hydroxy-3-[2-(2-hydroxyphenyl)-2-oxoethyl]-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one chemical structure, C24H21NO4, CAS 384359-07-3
3-Hydroxy-3-[2-(2-hydroxyphenyl)-2-oxoethyl]-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one
CAS 384359-07-3C24H21NO4
GLP-1R modulator C5 chemical structure, C24H21NO3, CAS 421578-93-0
GLP-1R modulator C5
CAS 421578-93-0C24H21NO3
3-Hydroxy-3-[2-(2-methoxyphenyl)-2-oxoethyl]-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one chemical structure, C25H23NO4, CAS 865551-24-2
3-Hydroxy-3-[2-(2-methoxyphenyl)-2-oxoethyl]-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one
CAS 865551-24-2C25H23NO4
3-[2-(4-Aminophenyl)-2-oxoethyl]-5-chloro-3-hydroxy-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one chemical structure, C24H21ClN2O3, CAS 690225-14-0
3-[2-(4-Aminophenyl)-2-oxoethyl]-5-chloro-3-hydroxy-1-(2-phenylethyl)-1,3-dihydro-2H-indol-2-one
CAS 690225-14-0C24H21ClN2O3