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Murcko scaffold

1,4-Piperazinedicarboxanilide scaffold

16 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
24
Chemicals
16
With full pages
4
Scaffold SMILES

O=C(Nc1ccccc1)N1CCN(C(=O)Nc2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1,4-Piperazinedicarboxanilide page
Murcko scaffold O=C(Nc1ccccc1)N1CCN(C(=O)Nc2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 16 of 16 chemicals

1,4-Piperazinedicarboxamide, n1,n4-bis(4-chlorophenyl)- chemical structure, C18H18Cl2N4O2, CAS 6269-42-7
1,4-Piperazinedicarboxamide, n1,n4-bis(4-chlorophenyl)-
CAS 6269-42-7C18H18Cl2N4O2
N~1~,N~4~-Bis(2,5-dichlorophenyl)piperazine-1,4-dicarboximidic acid chemical structure, C18H16Cl4N4O2, CAS 6277-04-9
N~1~,N~4~-Bis(2,5-dichlorophenyl)piperazine-1,4-dicarboximidic acid
CAS 6277-04-9C18H16Cl4N4O2
N1,4-dicarboxamide chemical structure, C18H18Br2N4O2, CAS 6277-05-0
N1,4-dicarboxamide
CAS 6277-05-0C18H18Br2N4O2
N~1~,N~4~-Bis(4-nitrophenyl)piperazine-1,4-dicarboxamide chemical structure, C18H18N6O6, CAS 6277-06-1
N~1~,N~4~-Bis(4-nitrophenyl)piperazine-1,4-dicarboxamide
CAS 6277-06-1C18H18N6O6
1,4-Piperazinedicarboxanilide chemical structure, C18H20N4O2, CAS 6511-89-3
1,4-Piperazinedicarboxanilide
CAS 6511-89-3C18H20N4O2
N,N'-Bis(2-methoxyphenyl)piperazine-1,4-dicarboxamide chemical structure, C20H24N4O4, CAS 6277-07-2
N,N'-Bis(2-methoxyphenyl)piperazine-1,4-dicarboxamide
CAS 6277-07-2C20H24N4O4
1-N,4-N-bis(4-methoxyphenyl)piperazine-1,4-dicarboxamide chemical structure, C20H24N4O4, CAS 6276-41-1
1-N,4-N-bis(4-methoxyphenyl)piperazine-1,4-dicarboxamide
CAS 6276-41-1C20H24N4O4
1-N,4-N-dimethyl-1-N,4-N-diphenylpiperazine-1,4-dicarboxamide chemical structure, C20H24N4O2, CAS 431916-91-5
1-N,4-N-dimethyl-1-N,4-N-diphenylpiperazine-1,4-dicarboxamide
CAS 431916-91-5C20H24N4O2
1-N,4-N-bis(3-chlorophenyl)piperazine-1,4-dicarboxamide chemical structure, C18H18Cl2N4O2, CAS 80490-82-0
1-N,4-N-bis(3-chlorophenyl)piperazine-1,4-dicarboxamide
CAS 80490-82-0C18H18Cl2N4O2
N1,N4-bis[3-(trifluoromethyl)phenyl]piperazine-1,4-dicarboxamide chemical structure, C20H18F6N4O2, CAS 710329-29-6
N1,N4-bis[3-(trifluoromethyl)phenyl]piperazine-1,4-dicarboxamide
CAS 710329-29-6C20H18F6N4O2
N~1~,N~4~-dimethyl-N~1~,N~4~-bis(4-methylphenyl)-1,4-piperazinedicarboxamide chemical structure, C22H28N4O2, CAS 701217-93-8
N~1~,N~4~-dimethyl-N~1~,N~4~-bis(4-methylphenyl)-1,4-piperazinedicarboxamide
CAS 701217-93-8C22H28N4O2
1-N,4-N-bis(2-methylphenyl)piperazine-1,4-dicarboxamide chemical structure, C20H24N4O2, CAS 80490-86-4
1-N,4-N-bis(2-methylphenyl)piperazine-1,4-dicarboxamide
CAS 80490-86-4C20H24N4O2
N-(4-Methylphenyl)(4-(N-(4-methylphenyl)carbamoyl)piperazinyl)formamide chemical structure, C20H24N4O2, CAS 80490-84-2
N-(4-Methylphenyl)(4-(N-(4-methylphenyl)carbamoyl)piperazinyl)formamide
CAS 80490-84-2C20H24N4O2
N1,N4-bis(4-chlorophenyl)-2,5-dimethylpiperazine-1,4-dicarboxamide chemical structure, C20H22Cl2N4O2, CAS 1023821-26-2
N1,N4-bis(4-chlorophenyl)-2,5-dimethylpiperazine-1,4-dicarboxamide
CAS 1023821-26-2C20H22Cl2N4O2
2,5-Dimethyl-N1,N4-diphenylpiperazine-1,4-dicarboxamide chemical structure, C20H24N4O2, CAS 1048915-01-0
2,5-Dimethyl-N1,N4-diphenylpiperazine-1,4-dicarboxamide
CAS 1048915-01-0C20H24N4O2
1-N,4-N-bis(3,4-dichlorophenyl)piperazine-1,4-dicarboxamide chemical structure, C18H16Cl4N4O2, CAS 80490-83-1
1-N,4-N-bis(3,4-dichlorophenyl)piperazine-1,4-dicarboxamide
CAS 80490-83-1C18H16Cl4N4O2