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Murcko scaffold

1-(Phenylsulfonyl)-4-(1-piperazinyl)-1H-indole scaffold

10 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
10
With full pages
1
Scaffold SMILES

O=S(=O)(c1ccccc1)n1ccc2c(N3CCNCC3)cccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(Phenylsulfonyl)-4-(1-piperazinyl)-1H-indole page
Murcko scaffold O=S(=O)(c1ccccc1)n1ccc2c(N3CCNCC3)cccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 10 of 10 chemicals

4-(4-Methyl-1-piperazinyl)-1-(phenylsulfonyl)-1H-indole chemical structure, C19H21N3O2S, CAS 431045-17-9
4-(4-Methyl-1-piperazinyl)-1-(phenylsulfonyl)-1H-indole
CAS 431045-17-9C19H21N3O2S
1H-Indole,2-iodo-1-(phenylsulfonyl)-4-(1-piperazinyl)-,hydrochloride chemical structure, C18H19ClIN3O2S, CAS 412049-40-2
1H-Indole,2-iodo-1-(phenylsulfonyl)-4-(1-piperazinyl)-,hydrochloride
CAS 412049-40-2C18H19ClIN3O2S
1-[(2-Bromophenyl)sulfonyl]-4-(1-piperazinyl)-1H-indole chemical structure, C18H18BrN3O2S, CAS 431045-45-3
1-[(2-Bromophenyl)sulfonyl]-4-(1-piperazinyl)-1H-indole
CAS 431045-45-3C18H18BrN3O2S
1-(Phenylsulfonyl)-4-(1-piperazinyl)-1H-indole chemical structure, C18H19N3O2S, CAS 412049-71-9
1-(Phenylsulfonyl)-4-(1-piperazinyl)-1H-indole
CAS 412049-71-9C18H19N3O2S
1-[(4-Bromophenyl)sulfonyl]-4-(1-piperazinyl)-1H-indole chemical structure, C18H18BrN3O2S, CAS 412048-92-1
1-[(4-Bromophenyl)sulfonyl]-4-(1-piperazinyl)-1H-indole
CAS 412048-92-1C18H18BrN3O2S
1-((4-(tert-Butyl)phenyl)sulfonyl)-4-(piperazin-1-yl)-1H-indole chemical structure, C22H27N3O2S, CAS 431045-39-5
1-((4-(tert-Butyl)phenyl)sulfonyl)-4-(piperazin-1-yl)-1H-indole
CAS 431045-39-5C22H27N3O2S
1-(3,5-Dichloro-benzenesulfonyl)-4-piperazin-1-yl-1H-indole chemical structure, C18H17Cl2N3O2S, CAS 431045-42-0
1-(3,5-Dichloro-benzenesulfonyl)-4-piperazin-1-yl-1H-indole
CAS 431045-42-0C18H17Cl2N3O2S
1-[(3-Chlorophenyl)sulfonyl]-4-(1-piperazinyl)-1H-indole chemical structure, C18H18ClN3O2S, CAS 431045-35-1
1-[(3-Chlorophenyl)sulfonyl]-4-(1-piperazinyl)-1H-indole
CAS 431045-35-1C18H18ClN3O2S
1-[(3-Bromophenyl)sulfonyl]-4-(1-piperazinyl)-1H-indole chemical structure, C18H18BrN3O2S, CAS 431045-30-6
1-[(3-Bromophenyl)sulfonyl]-4-(1-piperazinyl)-1H-indole
CAS 431045-30-6C18H18BrN3O2S
1-Piperazinecarboxylic acid,4-[2-iodo-1-(phenylsulfonyl)-1H-indol-4-yl]-,1,1-dimethylethyl ester chemical structure, C23H26IN3O4S, CAS 412049-39-9
1-Piperazinecarboxylic acid,4-[2-iodo-1-(phenylsulfonyl)-1H-indol-4-yl]-,1,1-dimethylethyl ester
CAS 412049-39-9C23H26IN3O4S