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Murcko scaffold

Ring system with 4 rings and 19 atoms

27 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
19
Chemicals
27
With full pages
4
Scaffold SMILES

O=c1[nH]cnc2c1C1(CCCC1)Cc1ccccc1-2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1[nH]cnc2c1C1(CCCC1)Cc1ccccc1-2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 27 of 27 chemicals

2-[[3-Ethyl-4-oxospiro[benzo[h]quinazoline-5(3H),1'-cyclopentane]-2(6H)-yl]thio]acetonitrile chemical structure, C20H21N3OS, CAS 337494-86-7
2-[[3-Ethyl-4-oxospiro[benzo[h]quinazoline-5(3H),1'-cyclopentane]-2(6H)-yl]thio]acetonitrile
CAS 337494-86-7C20H21N3OS
3-Methyl-2-methylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one chemical structure, C18H20N2OS, CAS 313519-87-8
3-Methyl-2-methylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one
CAS 313519-87-8C18H20N2OS
3-Aminospiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one chemical structure, C16H17N3O, CAS 221238-83-1
3-Aminospiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one
CAS 221238-83-1C16H17N3O
3-(2-Methylprop-2-enyl)-2-methylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one chemical structure, C21H24N2OS, CAS 327167-91-9
3-(2-Methylprop-2-enyl)-2-methylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one
CAS 327167-91-9C21H24N2OS
2-(Ethylsulfanyl)-3-(2-methyl-2-propenyl)-5,6-dihydrospiro(benzo[h]quinazoline-5,1'-cyclopentane)-4(3H)-one chemical structure, C22H26N2OS, CAS 353762-12-6
2-(Ethylsulfanyl)-3-(2-methyl-2-propenyl)-5,6-dihydrospiro(benzo[h]quinazoline-5,1'-cyclopentane)-4(3H)-one
CAS 353762-12-6C22H26N2OS
Ethyl 2-(4-oxo-3-prop-2-enylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-2-yl)sulfanylacetate chemical structure, C23H26N2O3S, CAS 332024-55-2
Ethyl 2-(4-oxo-3-prop-2-enylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-2-yl)sulfanylacetate
CAS 332024-55-2C23H26N2O3S
Ethyl 2-(3-methyl-4-oxospiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-2-yl)sulfanylacetate chemical structure, C21H24N2O3S, CAS 312596-38-6
Ethyl 2-(3-methyl-4-oxospiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-2-yl)sulfanylacetate
CAS 312596-38-6C21H24N2O3S
2-Ethylsulfanyl-3-prop-2-enylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one chemical structure, C21H24N2OS, CAS 332024-53-0
2-Ethylsulfanyl-3-prop-2-enylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one
CAS 332024-53-0C21H24N2OS
Ethyl 2-(3-ethyl-4-oxospiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-2-yl)sulfanylacetate chemical structure, C22H26N2O3S, CAS 330179-63-0
Ethyl 2-(3-ethyl-4-oxospiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-2-yl)sulfanylacetate
CAS 330179-63-0C22H26N2O3S
2-Butylsulfanyl-3-prop-2-enylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one chemical structure, C23H28N2OS, CAS 327169-63-1
2-Butylsulfanyl-3-prop-2-enylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one
CAS 327169-63-1C23H28N2OS
3-Methyl-2-prop-2-enylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one chemical structure, C20H22N2OS, CAS 312594-19-7
3-Methyl-2-prop-2-enylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one
CAS 312594-19-7C20H22N2OS
2-(4-Oxo-3-prop-2-enylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-2-yl)sulfanylacetonitrile chemical structure, C21H21N3OS, CAS 316360-54-0
2-(4-Oxo-3-prop-2-enylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-2-yl)sulfanylacetonitrile
CAS 316360-54-0C21H21N3OS
3-Prop-2-enyl-2-prop-2-ynylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one chemical structure, C22H22N2OS, CAS 328070-06-0
3-Prop-2-enyl-2-prop-2-ynylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one
CAS 328070-06-0C22H22N2OS
3-Prop-2-enyl-2-prop-2-enylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one chemical structure, C22H24N2OS, CAS 332024-56-3
3-Prop-2-enyl-2-prop-2-enylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one
CAS 332024-56-3C22H24N2OS
3-(2-Methylprop-2-enyl)-2-prop-2-ynylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one chemical structure, C23H24N2OS, CAS 354546-93-3
3-(2-Methylprop-2-enyl)-2-prop-2-ynylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one
CAS 354546-93-3C23H24N2OS
2-(Butylsulfanyl)-3-(2-methyl-2-propenyl)-5,6-dihydrospiro(benzo[h]quinazoline-5,1'-cyclopentane)-4(3H)-one chemical structure, C24H30N2OS, CAS 354547-08-3
2-(Butylsulfanyl)-3-(2-methyl-2-propenyl)-5,6-dihydrospiro(benzo[h]quinazoline-5,1'-cyclopentane)-4(3H)-one
CAS 354547-08-3C24H30N2OS
3-Ethyl-2-propylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one chemical structure, C21H26N2OS, CAS 327170-16-1
3-Ethyl-2-propylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one
CAS 327170-16-1C21H26N2OS
3-(Prop-2-en-1-yl)-2-(propylsulfanyl)-3H-spiro[benzo[h]quinazoline-5,1'-cyclopentan]-4(6H)-one chemical structure, C22H26N2OS, CAS 337496-43-2
3-(Prop-2-en-1-yl)-2-(propylsulfanyl)-3H-spiro[benzo[h]quinazoline-5,1'-cyclopentan]-4(6H)-one
CAS 337496-43-2C22H26N2OS
2-Ethylsulfanyl-3-methylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one chemical structure, C19H22N2OS, CAS 313519-88-9
2-Ethylsulfanyl-3-methylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one
CAS 313519-88-9C19H22N2OS
N-Allyl-2-(4-oxo-4,6-dihydro-3H-spiro[benzo[h]quinazoline-5,1'-cyclopentan]-2-yl)hydrazinecarbothioamide chemical structure, C20H23N5OS, CAS 375357-58-7
N-Allyl-2-(4-oxo-4,6-dihydro-3H-spiro[benzo[h]quinazoline-5,1'-cyclopentan]-2-yl)hydrazinecarbothioamide
CAS 375357-58-7C20H23N5OS
2-Butylsulfanylspiro[1,6-dihydrobenzo[h]quinazoline-5,1'-cyclopentane]-4-one chemical structure, C20H24N2OS, CAS 316362-42-2
2-Butylsulfanylspiro[1,6-dihydrobenzo[h]quinazoline-5,1'-cyclopentane]-4-one
CAS 316362-42-2C20H24N2OS
2-Prop-2-ynylsulfanylspiro[1,6-dihydrobenzo[h]quinazoline-5,1'-cyclopentane]-4-one chemical structure, C19H18N2OS, CAS 5728-09-6
2-Prop-2-ynylsulfanylspiro[1,6-dihydrobenzo[h]quinazoline-5,1'-cyclopentane]-4-one
CAS 5728-09-6C19H18N2OS
2-(Ethoxymethyl)spiro[1,6-dihydrobenzo[h]quinazoline-5,1'-cyclopentane]-4-one chemical structure, C19H22N2O2, CAS 304869-43-0
2-(Ethoxymethyl)spiro[1,6-dihydrobenzo[h]quinazoline-5,1'-cyclopentane]-4-one
CAS 304869-43-0C19H22N2O2
2-[(Dibutylamino)methyl]-5,6-dihydrospiro(benzo[h]quinazoline-5,1'-cyclopentane)-4(3H)-one chemical structure, C25H35N3O, CAS 304877-71-2
2-[(Dibutylamino)methyl]-5,6-dihydrospiro(benzo[h]quinazoline-5,1'-cyclopentane)-4(3H)-one
CAS 304877-71-2C25H35N3O