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Murcko scaffold

Ring system with 3 rings and 21 atoms

11 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
11
With full pages
6
Scaffold SMILES

O=C(Nc1c[nH]c(=O)[nH]c1=O)c1ccnc2ccccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1c[nH]c(=O)[nH]c1=O)c1ccnc2ccccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 11 of 11 chemicals

N-(6-Amino-1-butyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-chloro-N-methylquinoline-4-carboxamide chemical structure, C19H20ClN5O3, CAS 877973-39-2
N-(6-Amino-1-butyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-chloro-N-methylquinoline-4-carboxamide
CAS 877973-39-2C19H20ClN5O3
N-(6-Amino-1-butyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N-butyl-2-chloroquinoline-4-carboxamide chemical structure, C22H26ClN5O3, CAS 1016483-31-0
N-(6-Amino-1-butyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N-butyl-2-chloroquinoline-4-carboxamide
CAS 1016483-31-0C22H26ClN5O3
N-(6-Amino-1-butyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-chloro-N-(2-methoxyethyl)quinoline-4-carboxamide chemical structure, C21H24ClN5O4, CAS 1031533-79-5
N-(6-Amino-1-butyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-chloro-N-(2-methoxyethyl)quinoline-4-carboxamide
CAS 1031533-79-5C21H24ClN5O4
N-(6-Amino-2,4-dioxo-1-propyl-1,2,3,4-tetrahydropyrimidin-5-yl)-2-chloro-N-(2-methoxyethyl)quinoline-4-carboxamide chemical structure, C20H22ClN5O4, CAS 1031517-76-6
N-(6-Amino-2,4-dioxo-1-propyl-1,2,3,4-tetrahydropyrimidin-5-yl)-2-chloro-N-(2-methoxyethyl)quinoline-4-carboxamide
CAS 1031517-76-6C20H22ClN5O4
N-(6-Amino-1-butyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-chloro-N-(2-methylpropyl)quinoline-4-carboxamide chemical structure, C22H26ClN5O3, CAS 1031085-75-2
N-(6-Amino-1-butyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-chloro-N-(2-methylpropyl)quinoline-4-carboxamide
CAS 1031085-75-2C22H26ClN5O3
N-(6-Amino-1-butyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-chloro-N-ethylquinoline-4-carboxamide chemical structure, C20H22ClN5O3, CAS 1031074-96-0
N-(6-Amino-1-butyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-chloro-N-ethylquinoline-4-carboxamide
CAS 1031074-96-0C20H22ClN5O3
N-(6-Amino-1-butyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-chloro-N-(3-methylbutyl)quinoline-4-carboxamide chemical structure, C23H28ClN5O3, CAS 1031148-83-0
N-(6-Amino-1-butyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-chloro-N-(3-methylbutyl)quinoline-4-carboxamide
CAS 1031148-83-0C23H28ClN5O3
N-[6-Amino-1-(2-methylpropyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl]-2-chloro-N-(2-methylpropyl)quinoline-4-carboxamide chemical structure, C22H26ClN5O3, CAS 1031042-75-7
N-[6-Amino-1-(2-methylpropyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl]-2-chloro-N-(2-methylpropyl)quinoline-4-carboxamide
CAS 1031042-75-7C22H26ClN5O3
N-(6-Amino-2,4-dioxo-1-propyl-1,2,3,4-tetrahydropyrimidin-5-yl)-N-butyl-2-chloroquinoline-4-carboxamide chemical structure, C21H24ClN5O3, CAS 1090993-95-5
N-(6-Amino-2,4-dioxo-1-propyl-1,2,3,4-tetrahydropyrimidin-5-yl)-N-butyl-2-chloroquinoline-4-carboxamide
CAS 1090993-95-5C21H24ClN5O3
N-[6-Amino-1-(2-methylpropyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl]-N-butyl-2-chloroquinoline-4-carboxamide chemical structure, C22H26ClN5O3, CAS 1090985-22-0
N-[6-Amino-1-(2-methylpropyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl]-N-butyl-2-chloroquinoline-4-carboxamide
CAS 1090985-22-0C22H26ClN5O3
N-[6-Amino-1-(2-methylpropyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl]-2-chloro-N-(2-methoxyethyl)quinoline-4-carboxamide chemical structure, C21H24ClN5O4, CAS 1090891-63-6
N-[6-Amino-1-(2-methylpropyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl]-2-chloro-N-(2-methoxyethyl)quinoline-4-carboxamide
CAS 1090891-63-6C21H24ClN5O4