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Murcko scaffold

2-((2,5-Diphenyl-1H-imidazol-4-yl)thio)-N-(thiazol-2-yl)acetamide scaffold

41 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
27
Chemicals
41
With full pages
5
Scaffold SMILES

O=C(CSc1nc(-c2ccccc2)[nH]c1-c1ccccc1)Nc1nccs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-((2,5-Diphenyl-1H-imidazol-4-yl)thio)-N-(thiazol-2-yl)acetamide page
Murcko scaffold O=C(CSc1nc(-c2ccccc2)[nH]c1-c1ccccc1)Nc1nccs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 41 of 41 chemicals

2-{[2-(4-Ethoxyphenyl)-5-(4-fluorophenyl)-1H-imidazol-4-yl]sulfanyl}-N-(1,3-thiazol-2-yl)acetamide chemical structure, C22H19FN4O2S2, CAS 866346-76-1
2-{[2-(4-Ethoxyphenyl)-5-(4-fluorophenyl)-1H-imidazol-4-yl]sulfanyl}-N-(1,3-thiazol-2-yl)acetamide
CAS 866346-76-1C22H19FN4O2S2
2-{[5-(4-Methoxyphenyl)-2-(4-methylphenyl)-1H-imidazol-4-yl]sulfanyl}-N-(1,3-thiazol-2-yl)acetamide chemical structure, C22H20N4O2S2, CAS 866346-77-2
2-{[5-(4-Methoxyphenyl)-2-(4-methylphenyl)-1H-imidazol-4-yl]sulfanyl}-N-(1,3-thiazol-2-yl)acetamide
CAS 866346-77-2C22H20N4O2S2
2-[[5-(4-Methoxyphenyl)-2-(4-methylsulfanylphenyl)-1H-imidazol-4-yl]sulfanyl]-N-(1,3-thiazol-2-yl)acetamide chemical structure, C22H20N4O2S3, CAS 866346-78-3
2-[[5-(4-Methoxyphenyl)-2-(4-methylsulfanylphenyl)-1H-imidazol-4-yl]sulfanyl]-N-(1,3-thiazol-2-yl)acetamide
CAS 866346-78-3C22H20N4O2S3
2-{[2-(4-Fluorophenyl)-5-(4-methoxyphenyl)-1H-imidazol-4-yl]sulfanyl}-N-(1,3-thiazol-2-yl)acetamide chemical structure, C21H17FN4O2S2, CAS 866346-79-4
2-{[2-(4-Fluorophenyl)-5-(4-methoxyphenyl)-1H-imidazol-4-yl]sulfanyl}-N-(1,3-thiazol-2-yl)acetamide
CAS 866346-79-4C21H17FN4O2S2
2-{[5-(4-Chlorophenyl)-2-(4-methoxyphenyl)-1H-imidazol-4-yl]sulfanyl}-N-(1,3-thiazol-2-yl)acetamide chemical structure, C21H17ClN4O2S2, CAS 901258-98-8
2-{[5-(4-Chlorophenyl)-2-(4-methoxyphenyl)-1H-imidazol-4-yl]sulfanyl}-N-(1,3-thiazol-2-yl)acetamide
CAS 901258-98-8C21H17ClN4O2S2
2-{[2-(4-Chlorophenyl)-5-(4-methoxyphenyl)-1H-imidazol-4-yl]sulfanyl}-N-(1,3-thiazol-2-yl)acetamide chemical structure, C21H17ClN4O2S2, CAS 901259-19-6
2-{[2-(4-Chlorophenyl)-5-(4-methoxyphenyl)-1H-imidazol-4-yl]sulfanyl}-N-(1,3-thiazol-2-yl)acetamide
CAS 901259-19-6C21H17ClN4O2S2
2-{[5-(4-Methoxyphenyl)-2-phenyl-1H-imidazol-4-yl]thio}-N-1,3-thiazol-2-ylacetamide chemical structure, C21H18N4O2S2, CAS 901259-16-3
2-{[5-(4-Methoxyphenyl)-2-phenyl-1H-imidazol-4-yl]thio}-N-1,3-thiazol-2-ylacetamide
CAS 901259-16-3C21H18N4O2S2
2-((5-Phenyl-2-(m-tolyl)-1H-imidazol-4-yl)thio)-N-(thiazol-2-yl)acetamide chemical structure, C21H18N4OS2, CAS 901258-38-6
2-((5-Phenyl-2-(m-tolyl)-1H-imidazol-4-yl)thio)-N-(thiazol-2-yl)acetamide
CAS 901258-38-6C21H18N4OS2
2-((2-(4-Ethylphenyl)-5-phenyl-1H-imidazol-4-yl)thio)-N-(thiazol-2-yl)acetamide chemical structure, C22H20N4OS2, CAS 901258-40-0
2-((2-(4-Ethylphenyl)-5-phenyl-1H-imidazol-4-yl)thio)-N-(thiazol-2-yl)acetamide
CAS 901258-40-0C22H20N4OS2
2-((2-(4-Methoxyphenyl)-5-phenyl-1H-imidazol-4-yl)thio)-N-(thiazol-2-yl)acetamide chemical structure, C21H18N4O2S2, CAS 901258-42-2
2-((2-(4-Methoxyphenyl)-5-phenyl-1H-imidazol-4-yl)thio)-N-(thiazol-2-yl)acetamide
CAS 901258-42-2C21H18N4O2S2
2-((2-(3-Methoxyphenyl)-5-phenyl-1H-imidazol-4-yl)thio)-N-(thiazol-2-yl)acetamide chemical structure, C21H18N4O2S2, CAS 901258-44-4
2-((2-(3-Methoxyphenyl)-5-phenyl-1H-imidazol-4-yl)thio)-N-(thiazol-2-yl)acetamide
CAS 901258-44-4C21H18N4O2S2
2-((2-(4-Ethoxy-3-methoxyphenyl)-5-phenyl-1H-imidazol-4-yl)thio)-N-(thiazol-2-yl)acetamide chemical structure, C23H22N4O3S2, CAS 901258-48-8
2-((2-(4-Ethoxy-3-methoxyphenyl)-5-phenyl-1H-imidazol-4-yl)thio)-N-(thiazol-2-yl)acetamide
CAS 901258-48-8C23H22N4O3S2
2-{[2-(4-Ethoxyphenyl)-5-phenyl-1H-imidazol-4-yl]sulfanyl}-N-(1,3-thiazol-2-yl)acetamide chemical structure, C22H20N4O2S2, CAS 901258-50-2
2-{[2-(4-Ethoxyphenyl)-5-phenyl-1H-imidazol-4-yl]sulfanyl}-N-(1,3-thiazol-2-yl)acetamide
CAS 901258-50-2C22H20N4O2S2
2-((2-(4-(Methylthio)phenyl)-5-phenyl-1H-imidazol-4-yl)thio)-N-(thiazol-2-yl)acetamide chemical structure, C21H18N4OS3, CAS 901258-52-4
2-((2-(4-(Methylthio)phenyl)-5-phenyl-1H-imidazol-4-yl)thio)-N-(thiazol-2-yl)acetamide
CAS 901258-52-4C21H18N4OS3
2-((2-(4-Fluorophenyl)-5-phenyl-1H-imidazol-4-yl)thio)-N-(thiazol-2-yl)acetamide chemical structure, C20H15FN4OS2, CAS 901258-56-8
2-((2-(4-Fluorophenyl)-5-phenyl-1H-imidazol-4-yl)thio)-N-(thiazol-2-yl)acetamide
CAS 901258-56-8C20H15FN4OS2
2-((2-(3-Fluorophenyl)-5-phenyl-1H-imidazol-4-yl)thio)-N-(thiazol-2-yl)acetamide chemical structure, C20H15FN4OS2, CAS 950266-36-1
2-((2-(3-Fluorophenyl)-5-phenyl-1H-imidazol-4-yl)thio)-N-(thiazol-2-yl)acetamide
CAS 950266-36-1C20H15FN4OS2
2-((2-(4-Chlorophenyl)-5-phenyl-1H-imidazol-4-yl)thio)-N-(thiazol-2-yl)acetamide chemical structure, C20H15ClN4OS2, CAS 901258-58-0
2-((2-(4-Chlorophenyl)-5-phenyl-1H-imidazol-4-yl)thio)-N-(thiazol-2-yl)acetamide
CAS 901258-58-0C20H15ClN4OS2
2-((2-(3-Chlorophenyl)-5-phenyl-1H-imidazol-4-yl)thio)-N-(thiazol-2-yl)acetamide chemical structure, C20H15ClN4OS2, CAS 901258-60-4
2-((2-(3-Chlorophenyl)-5-phenyl-1H-imidazol-4-yl)thio)-N-(thiazol-2-yl)acetamide
CAS 901258-60-4C20H15ClN4OS2
2-((2-(4-Bromophenyl)-5-phenyl-1H-imidazol-4-yl)thio)-N-(thiazol-2-yl)acetamide chemical structure, C20H15BrN4OS2, CAS 901258-62-6
2-((2-(4-Bromophenyl)-5-phenyl-1H-imidazol-4-yl)thio)-N-(thiazol-2-yl)acetamide
CAS 901258-62-6C20H15BrN4OS2
2-((2-Phenyl-5-(p-tolyl)-1H-imidazol-4-yl)thio)-N-(thiazol-2-yl)acetamide chemical structure, C21H18N4OS2, CAS 950273-06-0
2-((2-Phenyl-5-(p-tolyl)-1H-imidazol-4-yl)thio)-N-(thiazol-2-yl)acetamide
CAS 950273-06-0C21H18N4OS2
2-((2,5-di-p-Tolyl-1H-imidazol-4-yl)thio)-N-(thiazol-2-yl)acetamide chemical structure, C22H20N4OS2, CAS 901258-64-8
2-((2,5-di-p-Tolyl-1H-imidazol-4-yl)thio)-N-(thiazol-2-yl)acetamide
CAS 901258-64-8C22H20N4OS2
2-((2-(4-Ethylphenyl)-5-(p-tolyl)-1H-imidazol-4-yl)thio)-N-(thiazol-2-yl)acetamide chemical structure, C23H22N4OS2, CAS 901258-66-0
2-((2-(4-Ethylphenyl)-5-(p-tolyl)-1H-imidazol-4-yl)thio)-N-(thiazol-2-yl)acetamide
CAS 901258-66-0C23H22N4OS2
2-((2-(4-Methoxyphenyl)-5-(p-tolyl)-1H-imidazol-4-yl)thio)-N-(thiazol-2-yl)acetamide chemical structure, C22H20N4O2S2, CAS 901258-68-2
2-((2-(4-Methoxyphenyl)-5-(p-tolyl)-1H-imidazol-4-yl)thio)-N-(thiazol-2-yl)acetamide
CAS 901258-68-2C22H20N4O2S2
2-((2-(3-Methoxyphenyl)-5-(p-tolyl)-1H-imidazol-4-yl)thio)-N-(thiazol-2-yl)acetamide chemical structure, C22H20N4O2S2, CAS 901258-71-7
2-((2-(3-Methoxyphenyl)-5-(p-tolyl)-1H-imidazol-4-yl)thio)-N-(thiazol-2-yl)acetamide
CAS 901258-71-7C22H20N4O2S2