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Murcko scaffold

Ring system with 3 rings and 20 atoms

8 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
8
With full pages
1
Scaffold SMILES

O=C(Nc1ccncc1)C1OCCC1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccncc1)C1OCCC1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 8 of 8 chemicals

4-[[[(2R,3S,4S,5R)-3-(3,4-Difluoro-2-hydroxyphenyl)tetrahydro-4,5-dimethyl-5-(trifluoromethyl)-2-furanyl]carbonyl]amino]-2-pyridinecarboxamide chemical structure, C20H18F5N3O4, CAS 2649467-91-2
4-[[[(2R,3S,4S,5R)-3-(3,4-Difluoro-2-hydroxyphenyl)tetrahydro-4,5-dimethyl-5-(trifluoromethyl)-2-furanyl]carbonyl]amino]-2-pyridinecarboxamide
CAS 2649467-91-2C20H18F5N3O4
Suzetrigine chemical structure, C21H20F5N3O4, CAS 2649467-58-1
Suzetrigine
CAS 2649467-58-1C21H20F5N3O4
4-[[[(2S,3R,4R,5S)-3-(3,4-Difluoro-2-methoxyphenyl)tetrahydro-4,5-dimethyl-5-(trifluoromethyl)-2-furanyl]carbonyl]amino]-2-pyridinecarboxamide chemical structure, C21H20F5N3O4, CAS 2649467-57-0
4-[[[(2S,3R,4R,5S)-3-(3,4-Difluoro-2-methoxyphenyl)tetrahydro-4,5-dimethyl-5-(trifluoromethyl)-2-furanyl]carbonyl]amino]-2-pyridinecarboxamide
CAS 2649467-57-0C21H20F5N3O4
4-[[Rel-(2R,3S,4R,5R)-3-(3,4-difluoro-2-methoxy-phenyl)-4,5-dimethyl-5-(trifluoromethyl)tetrahydrofuran-2-carbonyl]amino]pyridine-2-carboxamide chemical structure, C21H20F5N3O4, CAS 2649467-30-9
4-[[Rel-(2R,3S,4R,5R)-3-(3,4-difluoro-2-methoxy-phenyl)-4,5-dimethyl-5-(trifluoromethyl)tetrahydrofuran-2-carbonyl]amino]pyridine-2-carboxamide
CAS 2649467-30-9C21H20F5N3O4
Suzetrigine impurity 15 chemical structure, C21H20F5N3O4, CAS 2649467-63-8
Suzetrigine impurity 15
CAS 2649467-63-8C21H20F5N3O4
Suzetrigine impurity 13 chemical structure, C22H21F5N2O5, CAS 2879218-02-5
Suzetrigine impurity 13
CAS 2879218-02-5C22H21F5N2O5
4-((2R,3S,4S,5R)-3-(3,4-Difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)tetrahydrofuran-2-carboxamido)picolinic acid chemical structure, C21H19F5N2O5, CAS 2879216-22-3
4-((2R,3S,4S,5R)-3-(3,4-Difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)tetrahydrofuran-2-carboxamido)picolinic acid
CAS 2879216-22-3C21H19F5N2O5
Suzetrigine 4-desfluoro impurity chemical structure, C21H21F4N3O4, CAS 2879214-09-0
Suzetrigine 4-desfluoro impurity
CAS 2879214-09-0C21H21F4N3O4