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Murcko scaffold

Ring system with 3 rings and 19 atoms

18 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
18
With full pages
5
Scaffold SMILES

c1ccc(CSc2nccn2-c2ccccc2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(CSc2nccn2-c2ccccc2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 18 of 18 chemicals

2-Methylbenzyl 1-phenyl-1H-imidazol-2-yl sulfide chemical structure, C17H16N2S, CAS 478046-00-3
2-Methylbenzyl 1-phenyl-1H-imidazol-2-yl sulfide
CAS 478046-00-3C17H16N2S
3-Chlorobenzyl 1-phenyl-1H-imidazol-2-yl sulfide chemical structure, C16H13ClN2S, CAS 478046-10-5
3-Chlorobenzyl 1-phenyl-1H-imidazol-2-yl sulfide
CAS 478046-10-5C16H13ClN2S
2-[(2-Chloro-6-fluorobenzyl)sulfanyl]-1-phenyl-1H-imidazole chemical structure, C16H12ClFN2S, CAS 478046-19-4
2-[(2-Chloro-6-fluorobenzyl)sulfanyl]-1-phenyl-1H-imidazole
CAS 478046-19-4C16H12ClFN2S
2-[(2,4-Dichlorobenzyl)sulfanyl]-1-phenyl-1H-imidazole chemical structure, C16H12Cl2N2S, CAS 478046-21-8
2-[(2,4-Dichlorobenzyl)sulfanyl]-1-phenyl-1H-imidazole
CAS 478046-21-8C16H12Cl2N2S
2-Fluorobenzyl 1-phenyl-1H-imidazol-2-yl sulfide chemical structure, C16H13FN2S, CAS 478046-26-3
2-Fluorobenzyl 1-phenyl-1H-imidazol-2-yl sulfide
CAS 478046-26-3C16H13FN2S
4-Bromobenzyl 1-phenyl-1H-imidazol-2-yl sulfide chemical structure, C16H13BrN2S, CAS 478046-27-4
4-Bromobenzyl 1-phenyl-1H-imidazol-2-yl sulfide
CAS 478046-27-4C16H13BrN2S
4-Ethylbenzyl 1-phenyl-1H-imidazol-2-yl sulfide chemical structure, C18H18N2S, CAS 478046-30-9
4-Ethylbenzyl 1-phenyl-1H-imidazol-2-yl sulfide
CAS 478046-30-9C18H18N2S
1-(2-Chlorophenyl)-2-[[(2,6-dichlorophenyl)methyl]thio]-1H-imidazole chemical structure, C16H11Cl3N2S, CAS 667865-25-0
1-(2-Chlorophenyl)-2-[[(2,6-dichlorophenyl)methyl]thio]-1H-imidazole
CAS 667865-25-0C16H11Cl3N2S
Benzenamine, N,N-dimethyl-2'-(((1-(3-fluorophenyl)-1H-imidazol-2-yl)thio)methyl)-, dihydrochloride chemical structure, C18H20Cl2FN3S, CAS 123824-06-6
Benzenamine, N,N-dimethyl-2'-(((1-(3-fluorophenyl)-1H-imidazol-2-yl)thio)methyl)-, dihydrochloride
CAS 123824-06-6C18H20Cl2FN3S
Benzenamine, N,N-dimethyl-2-(((1-(4-methoxyphenyl)-1H-imidazol-2-yl)thio)methyl)-, dihydrochloride chemical structure, C19H23Cl2N3OS, CAS 123842-24-0
Benzenamine, N,N-dimethyl-2-(((1-(4-methoxyphenyl)-1H-imidazol-2-yl)thio)methyl)-, dihydrochloride
CAS 123842-24-0C19H23Cl2N3OS
1-Phenyl-2-[[4-(trifluoromethyl)phenyl]methylthio]imidazole chemical structure, C17H13F3N2S, CAS 478040-08-3
1-Phenyl-2-[[4-(trifluoromethyl)phenyl]methylthio]imidazole
CAS 478040-08-3C17H13F3N2S
2-(Benzylsulfanyl)-1-[2,4-dichloro-5-(2-methoxyethoxy)phenyl]-1H-imidazole chemical structure, C19H18Cl2N2O2S, CAS 338967-20-7
2-(Benzylsulfanyl)-1-[2,4-dichloro-5-(2-methoxyethoxy)phenyl]-1H-imidazole
CAS 338967-20-7C19H18Cl2N2O2S
2-(Benzylsulfanyl)-1-(2,4-dichloro-5-methoxyphenyl)-1H-imidazole chemical structure, C17H14Cl2N2OS, CAS 338967-09-2
2-(Benzylsulfanyl)-1-(2,4-dichloro-5-methoxyphenyl)-1H-imidazole
CAS 338967-09-2C17H14Cl2N2OS
2-(Benzylsulfanyl)-1-(2,4-dichloro-5-isopropoxyphenyl)-1H-imidazole chemical structure, C19H18Cl2N2OS, CAS 338967-21-8
2-(Benzylsulfanyl)-1-(2,4-dichloro-5-isopropoxyphenyl)-1H-imidazole
CAS 338967-21-8C19H18Cl2N2OS
1-(4-Methoxyphenyl)-2-[(phenylmethyl)thio]-1H-imidazole-4-carboxaldehyde chemical structure, C18H16N2O2S, CAS 3681-84-3
1-(4-Methoxyphenyl)-2-[(phenylmethyl)thio]-1H-imidazole-4-carboxaldehyde
CAS 3681-84-3C18H16N2O2S
3-({[1-(3-Methoxyphenyl)-1H-imidazol-2-yl]sulfanyl}methyl)benzamide chemical structure, C18H17N3O2S, CAS 1259160-00-3
3-({[1-(3-Methoxyphenyl)-1H-imidazol-2-yl]sulfanyl}methyl)benzamide
CAS 1259160-00-3C18H17N3O2S
2-(Benzylsulfanyl)-1-phenyl-1H-imidazole-4-carbaldehyde chemical structure, C17H14N2OS, CAS 50541-33-8
2-(Benzylsulfanyl)-1-phenyl-1H-imidazole-4-carbaldehyde
CAS 50541-33-8C17H14N2OS
Methyl 3-(2-{[(4-fluorophenyl)methyl]sulfanyl}-1H-imidazol-1-yl)benzoate chemical structure, C18H15FN2O2S, CAS 2741955-27-9
Methyl 3-(2-{[(4-fluorophenyl)methyl]sulfanyl}-1H-imidazol-1-yl)benzoate
CAS 2741955-27-9C18H15FN2O2S