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Murcko scaffold

1-[4-(Benzyloxy)phenyl]pyrrolidin-2-one scaffold

18 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
18
With full pages
8
Scaffold SMILES

O=C1CCCN1c1ccc(OCc2ccccc2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-[4-(Benzyloxy)phenyl]pyrrolidin-2-one page
Murcko scaffold O=C1CCCN1c1ccc(OCc2ccccc2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 18 of 18 chemicals

Methyl 1-[4-[(2-chlorophenyl)methoxy]phenyl]-5-oxopyrrolidine-3-carboxylate chemical structure, C19H18ClNO4, CAS 296893-28-2
Methyl 1-[4-[(2-chlorophenyl)methoxy]phenyl]-5-oxopyrrolidine-3-carboxylate
CAS 296893-28-2C19H18ClNO4
1-{4-[(2-Chlorophenyl)methoxy]phenyl}-5-oxopyrrolidine-3-carboxylic acid chemical structure, C18H16ClNO4, CAS 340320-17-4
1-{4-[(2-Chlorophenyl)methoxy]phenyl}-5-oxopyrrolidine-3-carboxylic acid
CAS 340320-17-4C18H16ClNO4
1-{4-[(4-Chlorobenzyl)oxy]phenyl}-5-oxo-N-propylpyrrolidine-3-carboxamide chemical structure, C21H23ClN2O3, CAS 364595-29-9
1-{4-[(4-Chlorobenzyl)oxy]phenyl}-5-oxo-N-propylpyrrolidine-3-carboxamide
CAS 364595-29-9C21H23ClN2O3
1-{4-[(4-Nitrobenzyl)oxy]phenyl}-5-oxopyrrolidine-3-carboxamide chemical structure, C18H17N3O5, CAS 462082-15-1
1-{4-[(4-Nitrobenzyl)oxy]phenyl}-5-oxopyrrolidine-3-carboxamide
CAS 462082-15-1C18H17N3O5
RefChem:382100 chemical structure, C18H17NO4, CAS 73422-90-9
RefChem:382100
CAS 73422-90-9C18H17NO4
1-{4-[(2,4-Dichlorophenyl)methoxy]phenyl}-5-oxopyrrolidine-3-carboxylic acid chemical structure, C18H15Cl2NO4, CAS 448188-95-2
1-{4-[(2,4-Dichlorophenyl)methoxy]phenyl}-5-oxopyrrolidine-3-carboxylic acid
CAS 448188-95-2C18H15Cl2NO4
1-{4-[(4-Chlorobenzyl)oxy]phenyl}-5-oxopyrrolidine-3-carboxylic acid chemical structure, C18H16ClNO4, CAS 364600-67-9
1-{4-[(4-Chlorobenzyl)oxy]phenyl}-5-oxopyrrolidine-3-carboxylic acid
CAS 364600-67-9C18H16ClNO4
1-{4-[(4-Bromobenzyl)oxy]phenyl}-5-oxopyrrolidine-3-carboxylic acid chemical structure, C18H16BrNO4, CAS 351066-93-8
1-{4-[(4-Bromobenzyl)oxy]phenyl}-5-oxopyrrolidine-3-carboxylic acid
CAS 351066-93-8C18H16BrNO4
Sembragiline chemical structure, C19H19FN2O3, CAS 676479-06-4
Sembragiline
CAS 676479-06-4C19H19FN2O3
(RS)-1-(4-Benzyloxy-phenyl)-4-hydroxymethyl-pyrrolidin-2-one chemical structure, C18H19NO3, CAS 73422-75-0
(RS)-1-(4-Benzyloxy-phenyl)-4-hydroxymethyl-pyrrolidin-2-one
CAS 73422-75-0C18H19NO3
1-[4-(Benzyloxy)phenyl]pyrrolidin-2-one chemical structure, C17H17NO2, CAS 439148-58-0
1-[4-(Benzyloxy)phenyl]pyrrolidin-2-one
CAS 439148-58-0C17H17NO2
1-{4-[(2,6-Dichlorobenzyl)oxy]phenyl}-5-oxopyrrolidine-3-carboxylic acid chemical structure, C18H15Cl2NO4, CAS 870541-43-8
1-{4-[(2,6-Dichlorobenzyl)oxy]phenyl}-5-oxopyrrolidine-3-carboxylic acid
CAS 870541-43-8C18H15Cl2NO4
N,N-Dimethyl-3-[[4-(2-oxo-1-pyrrolidinyl)phenoxy]methyl]benzenesulfonamide chemical structure, C19H22N2O4S, CAS 950000-16-5
N,N-Dimethyl-3-[[4-(2-oxo-1-pyrrolidinyl)phenoxy]methyl]benzenesulfonamide
CAS 950000-16-5C19H22N2O4S
(RS)-1-[4-(4-Fluoro-benzyloxy)-phenyl]-5-oxo-pyrrolidine-3-carboxylic acid chemical structure, C18H16FNO4, CAS 676479-42-8
(RS)-1-[4-(4-Fluoro-benzyloxy)-phenyl]-5-oxo-pyrrolidine-3-carboxylic acid
CAS 676479-42-8C18H16FNO4
1-[4-[(3,4-Dichlorophenyl)methoxy]phenyl]-5-oxopyrrolidine-3-carboxylic acid chemical structure, C18H15Cl2NO4, CAS 928712-66-7
1-[4-[(3,4-Dichlorophenyl)methoxy]phenyl]-5-oxopyrrolidine-3-carboxylic acid
CAS 928712-66-7C18H15Cl2NO4
1-[4-[(2-Fluorophenyl)methoxy]phenyl]-5-oxopyrrolidine-3-carboxylic acid chemical structure, C18H16FNO4, CAS 676479-47-3
1-[4-[(2-Fluorophenyl)methoxy]phenyl]-5-oxopyrrolidine-3-carboxylic acid
CAS 676479-47-3C18H16FNO4
1-[4-[(4-Nitrophenyl)methoxy]phenyl]-5-oxopyrrolidine-3-carboxylic acid chemical structure, C18H16N2O6, CAS 928712-72-5
1-[4-[(4-Nitrophenyl)methoxy]phenyl]-5-oxopyrrolidine-3-carboxylic acid
CAS 928712-72-5C18H16N2O6
(R)-1-(4-((3-Fluorobenzyl)oxy)phenyl)-5-oxopyrrolidine-3-carboxylic acid chemical structure, C18H16FNO4, CAS 676472-88-1
(R)-1-(4-((3-Fluorobenzyl)oxy)phenyl)-5-oxopyrrolidine-3-carboxylic acid
CAS 676472-88-1C18H16FNO4