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Murcko scaffold

Ring system with 3 rings and 20 atoms

90 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
90
With full pages
20
Scaffold SMILES

O=C(Nc1ccc(N2CCCC2)cc1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccc(N2CCCC2)cc1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 90 chemicals

3,4,5-Trimethoxy-N-[4-(pyrrolidin-1-yl)phenyl]benzamide chemical structure, C20H24N2O4, CAS 102457-74-9
3,4,5-Trimethoxy-N-[4-(pyrrolidin-1-yl)phenyl]benzamide
CAS 102457-74-9C20H24N2O4
3,5-Dibromo-2-hydroxy-N-[3-nitro-4-(pyrrolidin-1-yl)phenyl]benzamide chemical structure, C17H15Br2N3O4, CAS 72670-67-8
3,5-Dibromo-2-hydroxy-N-[3-nitro-4-(pyrrolidin-1-yl)phenyl]benzamide
CAS 72670-67-8C17H15Br2N3O4
4-Bromo-N-(4-pyrrolidin-1-ylphenyl)benzamide chemical structure, C17H17BrN2O, CAS 431921-38-9
4-Bromo-N-(4-pyrrolidin-1-ylphenyl)benzamide
CAS 431921-38-9C17H17BrN2O
N-[3-Chloro-4-(pyrrolidin-1-yl)phenyl]-3-methoxybenzamide chemical structure, C18H19ClN2O2, CAS 364745-24-4
N-[3-Chloro-4-(pyrrolidin-1-yl)phenyl]-3-methoxybenzamide
CAS 364745-24-4C18H19ClN2O2
N-(3-Chloro-4-pyrrolidin-1-ylphenyl)-4-nitrobenzamide chemical structure, C17H16ClN3O3, CAS 431909-42-1
N-(3-Chloro-4-pyrrolidin-1-ylphenyl)-4-nitrobenzamide
CAS 431909-42-1C17H16ClN3O3
3,4-Dimethoxy-N-(4-pyrrolidin-1-ylphenyl)benzamide chemical structure, C19H22N2O3, CAS 369402-59-5
3,4-Dimethoxy-N-(4-pyrrolidin-1-ylphenyl)benzamide
CAS 369402-59-5C19H22N2O3
N-(3-Chloro-4-pyrrolidin-1-ylphenyl)-4-methylbenzamide chemical structure, C18H19ClN2O, CAS 431917-87-2
N-(3-Chloro-4-pyrrolidin-1-ylphenyl)-4-methylbenzamide
CAS 431917-87-2C18H19ClN2O
2-Chloro-N-(4-pyrrolidin-1-ylphenyl)benzamide chemical structure, C17H17ClN2O, CAS 586993-56-8
2-Chloro-N-(4-pyrrolidin-1-ylphenyl)benzamide
CAS 586993-56-8C17H17ClN2O
N-(3-Chloro-4-pyrrolidin-1-ylphenyl)-4-methoxybenzamide chemical structure, C18H19ClN2O2, CAS 380308-10-1
N-(3-Chloro-4-pyrrolidin-1-ylphenyl)-4-methoxybenzamide
CAS 380308-10-1C18H19ClN2O2
3,4-Dimethyl-N-(4-pyrrolidin-1-ylphenyl)benzamide chemical structure, C19H22N2O, CAS 431927-98-9
3,4-Dimethyl-N-(4-pyrrolidin-1-ylphenyl)benzamide
CAS 431927-98-9C19H22N2O
4-Propan-2-yloxy-N-(4-pyrrolidin-1-ylphenyl)benzamide chemical structure, C20H24N2O2, CAS 432008-91-8
4-Propan-2-yloxy-N-(4-pyrrolidin-1-ylphenyl)benzamide
CAS 432008-91-8C20H24N2O2
3,5-Dimethoxy-N-(4-pyrrolidin-1-ylphenyl)benzamide chemical structure, C19H22N2O3, CAS 431941-11-6
3,5-Dimethoxy-N-(4-pyrrolidin-1-ylphenyl)benzamide
CAS 431941-11-6C19H22N2O3
2-Fluoro-N-(4-pyrrolidin-1-ylphenyl)benzamide chemical structure, C17H17FN2O, CAS 432011-21-7
2-Fluoro-N-(4-pyrrolidin-1-ylphenyl)benzamide
CAS 432011-21-7C17H17FN2O
N-(3-Chloro-4-pyrrolidin-1-ylphenyl)-3,4-dimethylbenzamide chemical structure, C19H21ClN2O, CAS 432013-10-0
N-(3-Chloro-4-pyrrolidin-1-ylphenyl)-3,4-dimethylbenzamide
CAS 432013-10-0C19H21ClN2O
3,5-Dimethyl-N-(4-pyrrolidin-1-ylphenyl)benzamide chemical structure, C19H22N2O, CAS 769146-18-1
3,5-Dimethyl-N-(4-pyrrolidin-1-ylphenyl)benzamide
CAS 769146-18-1C19H22N2O
N-[3-Chloro-4-(pyrrolidin-1-yl)phenyl]-2,4-dimethylbenzamide chemical structure, C19H21ClN2O, CAS 676156-62-0
N-[3-Chloro-4-(pyrrolidin-1-yl)phenyl]-2,4-dimethylbenzamide
CAS 676156-62-0C19H21ClN2O
N-(3-Chloro-4-pyrrolidin-1-ylphenyl)-3,5-dimethylbenzamide chemical structure, C19H21ClN2O, CAS 706771-57-5
N-(3-Chloro-4-pyrrolidin-1-ylphenyl)-3,5-dimethylbenzamide
CAS 706771-57-5C19H21ClN2O
N-(3-Chloro-4-pyrrolidin-1-ylphenyl)-4-fluorobenzamide chemical structure, C17H16ClFN2O, CAS 432013-35-9
N-(3-Chloro-4-pyrrolidin-1-ylphenyl)-4-fluorobenzamide
CAS 432013-35-9C17H16ClFN2O
N-[3-Chloro-4-(1-pyrrolidinyl)phenyl]-2-nitrobenzamide chemical structure, C17H16ClN3O3, CAS 432019-21-1
N-[3-Chloro-4-(1-pyrrolidinyl)phenyl]-2-nitrobenzamide
CAS 432019-21-1C17H16ClN3O3
4-(Propan-2-yl)-N-[4-(pyrrolidin-1-yl)phenyl]benzamide chemical structure, C20H24N2O, CAS 431938-22-6
4-(Propan-2-yl)-N-[4-(pyrrolidin-1-yl)phenyl]benzamide
CAS 431938-22-6C20H24N2O
4-Chloro-3-nitro-N-[4-(pyrrolidin-1-yl)phenyl]benzamide chemical structure, C17H16ClN3O3, CAS 431980-50-6
4-Chloro-3-nitro-N-[4-(pyrrolidin-1-yl)phenyl]benzamide
CAS 431980-50-6C17H16ClN3O3
3-Chloro-4-methyl-N-(4-pyrrolidin-1-ylphenyl)benzamide chemical structure, C18H19ClN2O, CAS 432010-85-0
3-Chloro-4-methyl-N-(4-pyrrolidin-1-ylphenyl)benzamide
CAS 432010-85-0C18H19ClN2O
2-Methyl-3-nitro-N-[4-(pyrrolidin-1-yl)phenyl]benzamide chemical structure, C18H19N3O3, CAS 432017-80-6
2-Methyl-3-nitro-N-[4-(pyrrolidin-1-yl)phenyl]benzamide
CAS 432017-80-6C18H19N3O3
3-(Propan-2-yloxy)-N-[4-(pyrrolidin-1-yl)phenyl]benzamide chemical structure, C20H24N2O2, CAS 431908-52-0
3-(Propan-2-yloxy)-N-[4-(pyrrolidin-1-yl)phenyl]benzamide
CAS 431908-52-0C20H24N2O2