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Murcko scaffold

Ring system with 3 rings and 22 atoms

14 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
14
With full pages
2
Scaffold SMILES

O=C(CC(c1ccccc1)c1ccccc1)Nc1nncs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CC(c1ccccc1)c1ccccc1)Nc1nncs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 14 of 14 chemicals

N-(5-Methyl-1,3,4-thiadiazol-2-yl)-3,3-diphenylpropanamide chemical structure, C18H17N3OS, CAS 349439-35-6
N-(5-Methyl-1,3,4-thiadiazol-2-yl)-3,3-diphenylpropanamide
CAS 349439-35-6C18H17N3OS
N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-3,3-diphenylpropanamide chemical structure, C19H19N3OS, CAS 353471-95-1
N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-3,3-diphenylpropanamide
CAS 353471-95-1C19H19N3OS
N-[5-(Ethylsulfanyl)-1,3,4-thiadiazol-2-yl]-3,3-diphenylpropanamide chemical structure, C19H19N3OS2, CAS 445254-70-6
N-[5-(Ethylsulfanyl)-1,3,4-thiadiazol-2-yl]-3,3-diphenylpropanamide
CAS 445254-70-6C19H19N3OS2
N-(5-tert-Butyl-1,3,4-thiadiazol-2-yl)-3,3-diphenylpropanamide chemical structure, C21H23N3OS, CAS 448912-66-1
N-(5-tert-Butyl-1,3,4-thiadiazol-2-yl)-3,3-diphenylpropanamide
CAS 448912-66-1C21H23N3OS
N-[5-(2-Methylpropyl)-1,3,4-thiadiazol-2-yl]-3,3-diphenylpropanamide chemical structure, C21H23N3OS, CAS 519170-56-0
N-[5-(2-Methylpropyl)-1,3,4-thiadiazol-2-yl]-3,3-diphenylpropanamide
CAS 519170-56-0C21H23N3OS
N-[5-(2,2-Dimethylpropyl)-1,3,4-thiadiazol-2-yl]-3,3-diphenylpropanamide chemical structure, C22H25N3OS, CAS 590377-32-5
N-[5-(2,2-Dimethylpropyl)-1,3,4-thiadiazol-2-yl]-3,3-diphenylpropanamide
CAS 590377-32-5C22H25N3OS
3,3-Diphenyl-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]propanamide chemical structure, C18H14F3N3OS, CAS 590398-94-0
3,3-Diphenyl-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]propanamide
CAS 590398-94-0C18H14F3N3OS
N-(5-Pentyl-1,3,4-thiadiazol-2-yl)-3,3-diphenylpropanamide chemical structure, C22H25N3OS, CAS 708237-55-2
N-(5-Pentyl-1,3,4-thiadiazol-2-yl)-3,3-diphenylpropanamide
CAS 708237-55-2C22H25N3OS
N-[5-(2-Methoxyethylsulfanyl)-1,3,4-thiadiazol-2-yl]-3,3-diphenylpropanamide chemical structure, C20H21N3O2S2, CAS 710977-09-6
N-[5-(2-Methoxyethylsulfanyl)-1,3,4-thiadiazol-2-yl]-3,3-diphenylpropanamide
CAS 710977-09-6C20H21N3O2S2
N-(5-Butyl-1,3,4-thiadiazol-2-yl)-3,3-diphenylpropanamide chemical structure, C21H23N3OS, CAS 768292-72-4
N-(5-Butyl-1,3,4-thiadiazol-2-yl)-3,3-diphenylpropanamide
CAS 768292-72-4C21H23N3OS
N-[5-(Methoxymethyl)-1,3,4-thiadiazol-2-yl]-3,3-diphenylpropanamide chemical structure, C19H19N3O2S, CAS 590377-31-4
N-[5-(Methoxymethyl)-1,3,4-thiadiazol-2-yl]-3,3-diphenylpropanamide
CAS 590377-31-4C19H19N3O2S
3,3-Diphenyl-N-(5-propan-2-yl-1,3,4-thiadiazol-2-yl)propanamide chemical structure, C20H21N3OS, CAS 690969-87-0
3,3-Diphenyl-N-(5-propan-2-yl-1,3,4-thiadiazol-2-yl)propanamide
CAS 690969-87-0C20H21N3OS
N-[5-(Pentan-2-yl)-1,3,4-thiadiazol-2-yl]-3,3-diphenylpropanamide chemical structure, C22H25N3OS, CAS 710976-98-0
N-[5-(Pentan-2-yl)-1,3,4-thiadiazol-2-yl]-3,3-diphenylpropanamide
CAS 710976-98-0C22H25N3OS
N-[5-(2-Ethoxyethyl)-1,3,4-thiadiazol-2-yl]-3,3-diphenylpropanamide chemical structure, C21H23N3O2S, CAS 717833-17-5
N-[5-(2-Ethoxyethyl)-1,3,4-thiadiazol-2-yl]-3,3-diphenylpropanamide
CAS 717833-17-5C21H23N3O2S