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Murcko scaffold

Ring system with 4 rings and 23 atoms

27 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
27
With full pages
11
Scaffold SMILES

O=C(Nc1ccccc1)c1cc2cnn(-c3ccccc3)c2s1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccccc1)c1cc2cnn(-c3ccccc3)c2s1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 27 of 27 chemicals

3-Methyl-N-(4-methylphenyl)-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide chemical structure, C20H17N3OS, CAS 296262-40-3
3-Methyl-N-(4-methylphenyl)-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide
CAS 296262-40-3C20H17N3OS
N,3-dimethyl-N,1-diphenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide chemical structure, C20H17N3OS, CAS 306958-52-1
N,3-dimethyl-N,1-diphenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide
CAS 306958-52-1C20H17N3OS
3-Methyl-1-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-thieno[2,3-c]pyrazole-5-carboxamide chemical structure, C20H14F3N3OS, CAS 296262-12-9
3-Methyl-1-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-thieno[2,3-c]pyrazole-5-carboxamide
CAS 296262-12-9C20H14F3N3OS
Ethyl 4-(3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamido)benzoate chemical structure, C22H19N3O3S, CAS 296262-26-5
Ethyl 4-(3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamido)benzoate
CAS 296262-26-5C22H19N3O3S
N-(2,6-Dimethylphenyl)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide chemical structure, C21H19N3OS, CAS 309726-04-3
N-(2,6-Dimethylphenyl)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide
CAS 309726-04-3C21H19N3OS
N-(2,5-Dichlorophenyl)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide chemical structure, C19H13Cl2N3OS, CAS 302560-92-5
N-(2,5-Dichlorophenyl)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide
CAS 302560-92-5C19H13Cl2N3OS
Methyl 2-{[(3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazol-5-yl)carbonyl]amino}benzoate chemical structure, C21H17N3O3S, CAS 378208-24-3
Methyl 2-{[(3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazol-5-yl)carbonyl]amino}benzoate
CAS 378208-24-3C21H17N3O3S
N-(2,4-Dimethylphenyl)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide chemical structure, C21H19N3OS, CAS 324526-45-6
N-(2,4-Dimethylphenyl)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide
CAS 324526-45-6C21H19N3OS
N-(2,4-Dimethoxyphenyl)-3-methyl-1-phenylthieno[2,3-c]pyrazole-5-carboxamide chemical structure, C21H19N3O3S, CAS 442653-29-4
N-(2,4-Dimethoxyphenyl)-3-methyl-1-phenylthieno[2,3-c]pyrazole-5-carboxamide
CAS 442653-29-4C21H19N3O3S
N-(2-Methoxy-5-methylphenyl)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide chemical structure, C21H19N3O2S, CAS 313968-25-1
N-(2-Methoxy-5-methylphenyl)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide
CAS 313968-25-1C21H19N3O2S
N-(2-Chlorophenyl)-3-methyl-1-phenylthieno[2,3-c]pyrazole-5-carboxamide chemical structure, C19H14ClN3OS, CAS 314047-22-8
N-(2-Chlorophenyl)-3-methyl-1-phenylthieno[2,3-c]pyrazole-5-carboxamide
CAS 314047-22-8C19H14ClN3OS
N-(4-Bromophenyl)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide chemical structure, C19H14BrN3OS, CAS 313968-26-2
N-(4-Bromophenyl)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide
CAS 313968-26-2C19H14BrN3OS
3-Methyl-N-(3-nitrophenyl)-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide chemical structure, C19H14N4O3S, CAS 296262-05-0
3-Methyl-N-(3-nitrophenyl)-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide
CAS 296262-05-0C19H14N4O3S
N-(5-Chloro-2-methoxyphenyl)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide chemical structure, C20H16ClN3O2S, CAS 332351-97-0
N-(5-Chloro-2-methoxyphenyl)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide
CAS 332351-97-0C20H16ClN3O2S
N-(3,4-Dimethylphenyl)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide chemical structure, C21H19N3OS, CAS 444152-63-0
N-(3,4-Dimethylphenyl)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide
CAS 444152-63-0C21H19N3OS
N-(4-Chlorophenyl)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide chemical structure, C19H14ClN3OS, CAS 296262-27-6
N-(4-Chlorophenyl)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide
CAS 296262-27-6C19H14ClN3OS
3-Methyl-N-(4-methyl-3-nitrophenyl)-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide chemical structure, C20H16N4O3S, CAS 328548-58-9
3-Methyl-N-(4-methyl-3-nitrophenyl)-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide
CAS 328548-58-9C20H16N4O3S
N-(2-Fluorophenyl)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide chemical structure, C19H14FN3OS, CAS 458527-38-3
N-(2-Fluorophenyl)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide
CAS 458527-38-3C19H14FN3OS
N-(3-Chloro-2-methylphenyl)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide chemical structure, C20H16ClN3OS, CAS 328548-57-8
N-(3-Chloro-2-methylphenyl)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide
CAS 328548-57-8C20H16ClN3OS
N-(3-Chloro-4-fluorophenyl)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide chemical structure, C19H13ClFN3OS, CAS 380309-56-8
N-(3-Chloro-4-fluorophenyl)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide
CAS 380309-56-8C19H13ClFN3OS
N-(3-Fluorophenyl)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide chemical structure, C19H14FN3OS, CAS 431937-60-9
N-(3-Fluorophenyl)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide
CAS 431937-60-9C19H14FN3OS
N-(4-Ethoxyphenyl)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide chemical structure, C21H19N3O2S, CAS 296262-08-3
N-(4-Ethoxyphenyl)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide
CAS 296262-08-3C21H19N3O2S
N-(2,4-Dibromophenyl)-1-(4-fluorophenyl)-3-methylthieno[2,3-c]pyrazole-5-carboxamide chemical structure, C19H12Br2FN3OS, CAS 5498-53-3
N-(2,4-Dibromophenyl)-1-(4-fluorophenyl)-3-methylthieno[2,3-c]pyrazole-5-carboxamide
CAS 5498-53-3C19H12Br2FN3OS
N-(2-Carbamoylphenyl)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide chemical structure, C20H16N4O2S, CAS 380216-64-8
N-(2-Carbamoylphenyl)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide
CAS 380216-64-8C20H16N4O2S