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Murcko scaffold

Ring system with 4 rings and 20 atoms

23 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
20
Chemicals
23
With full pages
8
Scaffold SMILES

O=c1[nH]cnc2c1C1(CCCCC1)Cc1ccccc1-2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1[nH]cnc2c1C1(CCCCC1)Cc1ccccc1-2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 23 of 23 chemicals

N-(4-Oxospiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-3-yl)butanamide chemical structure, C21H25N3O2, CAS 179946-10-2
N-(4-Oxospiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-3-yl)butanamide
CAS 179946-10-2C21H25N3O2
Spiro(benzo(h)quinazoline-5(3H),1'-cyclohexan)-4(6H)-one, 2-(ethylthio)-3-methyl- chemical structure, C20H24N2OS, CAS 172984-36-0
Spiro(benzo(h)quinazoline-5(3H),1'-cyclohexan)-4(6H)-one, 2-(ethylthio)-3-methyl-
CAS 172984-36-0C20H24N2OS
3-Ethyl-2-methylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-4-one chemical structure, C20H24N2OS, CAS 337495-07-5
3-Ethyl-2-methylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-4-one
CAS 337495-07-5C20H24N2OS
3-Methyl-2-methylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-4-one chemical structure, C19H22N2OS, CAS 331837-22-0
3-Methyl-2-methylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-4-one
CAS 331837-22-0C19H22N2OS
3-(2-Methylprop-2-enyl)-2-methylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-4-one chemical structure, C22H26N2OS, CAS 353762-13-7
3-(2-Methylprop-2-enyl)-2-methylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-4-one
CAS 353762-13-7C22H26N2OS
2-(3-Ethyl-4-oxospiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-2-yl)sulfanylacetamide chemical structure, C21H25N3O2S, CAS 328072-56-6
2-(3-Ethyl-4-oxospiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-2-yl)sulfanylacetamide
CAS 328072-56-6C21H25N3O2S
2-Methylsulfanyl-3-prop-2-enylspiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-4-one chemical structure, C21H24N2OS, CAS 332024-46-1
2-Methylsulfanyl-3-prop-2-enylspiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-4-one
CAS 332024-46-1C21H24N2OS
2-(3-Methyl-4-oxospiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-2-yl)sulfanylacetamide chemical structure, C20H23N3O2S, CAS 380667-21-0
2-(3-Methyl-4-oxospiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-2-yl)sulfanylacetamide
CAS 380667-21-0C20H23N3O2S
2-(3-Methyl-4-oxospiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-2-yl)sulfanylacetonitrile chemical structure, C20H21N3OS, CAS 328068-36-6
2-(3-Methyl-4-oxospiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-2-yl)sulfanylacetonitrile
CAS 328068-36-6C20H21N3OS
RefChem:124089 chemical structure, C24H30N2OS, CAS 328070-87-7
RefChem:124089
CAS 328070-87-7C24H30N2OS
Spiro(benzo(h)quinazoline-5(3H),1'-cyclohexan)-4(6H)-one, 3-methyl-2-(2-propenylthio)- chemical structure, C21H24N2OS, CAS 172984-37-1
Spiro(benzo(h)quinazoline-5(3H),1'-cyclohexan)-4(6H)-one, 3-methyl-2-(2-propenylthio)-
CAS 172984-37-1C21H24N2OS
2-(4-Oxo-3-prop-2-enylspiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-2-yl)sulfanylacetonitrile chemical structure, C22H23N3OS, CAS 332024-49-4
2-(4-Oxo-3-prop-2-enylspiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-2-yl)sulfanylacetonitrile
CAS 332024-49-4C22H23N3OS
Ethyl 2-(4-oxo-3-prop-2-enylspiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-2-yl)sulfanylacetate chemical structure, C24H28N2O3S, CAS 332024-47-2
Ethyl 2-(4-oxo-3-prop-2-enylspiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-2-yl)sulfanylacetate
CAS 332024-47-2C24H28N2O3S
Ethyl 2-[3-(2-methylprop-2-enyl)-4-oxospiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-2-yl]sulfanylacetate chemical structure, C25H30N2O3S, CAS 354547-04-9
Ethyl 2-[3-(2-methylprop-2-enyl)-4-oxospiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-2-yl]sulfanylacetate
CAS 354547-04-9C25H30N2O3S
3-Methyl-2-prop-2-ynylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-4-one chemical structure, C21H22N2OS, CAS 5684-07-1
3-Methyl-2-prop-2-ynylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-4-one
CAS 5684-07-1C21H22N2OS
3-Ethyl-2-prop-2-ynylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-4-one chemical structure, C22H24N2OS, CAS 337495-16-6
3-Ethyl-2-prop-2-ynylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-4-one
CAS 337495-16-6C22H24N2OS
2-(3-Butyl-4-oxospiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-2-yl)sulfanylacetamide chemical structure, C23H29N3O2S, CAS 488716-81-0
2-(3-Butyl-4-oxospiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-2-yl)sulfanylacetamide
CAS 488716-81-0C23H29N3O2S
N,N-Diethyl-2-((3-(2-methylallyl)-4-oxo-4,6-dihydro-3H-spiro[benzo[h]quinazoline-5,1'-cyclohexan]-2-yl)thio)acetamide chemical structure, C27H35N3O2S, CAS 488732-59-8
N,N-Diethyl-2-((3-(2-methylallyl)-4-oxo-4,6-dihydro-3H-spiro[benzo[h]quinazoline-5,1'-cyclohexan]-2-yl)thio)acetamide
CAS 488732-59-8C27H35N3O2S
2-(2-Hydroxyethylsulfanyl)-3-methylspiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-4-one chemical structure, C20H24N2O2S, CAS 827010-93-5
2-(2-Hydroxyethylsulfanyl)-3-methylspiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-4-one
CAS 827010-93-5C20H24N2O2S
3-Prop-2-enyl-2-prop-2-enylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-4-one chemical structure, C23H26N2OS, CAS 5705-09-9
3-Prop-2-enyl-2-prop-2-enylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-4-one
CAS 5705-09-9C23H26N2OS
Acetic acid, ((4,6-dihydro-3-methyl-4-oxospiro(benzo(h)quinazoline-5(3H),1'-cyclohexan)-2-yl)thio)-, ethyl ester chemical structure, C22H26N2O3S, CAS 172984-39-3
Acetic acid, ((4,6-dihydro-3-methyl-4-oxospiro(benzo(h)quinazoline-5(3H),1'-cyclohexan)-2-yl)thio)-, ethyl ester
CAS 172984-39-3C22H26N2O3S
N-(4-Oxo-5,6-dihydrospiro[benzo[h]quinazoline-5,1'-cyclohexane]-3(4H)-yl)propanamide chemical structure, C20H23N3O2, CAS 179946-09-9
N-(4-Oxo-5,6-dihydrospiro[benzo[h]quinazoline-5,1'-cyclohexane]-3(4H)-yl)propanamide
CAS 179946-09-9C20H23N3O2
2-Prop-2-ynylsulfanylspiro[1,6-dihydrobenzo[h]quinazoline-5,1'-cyclohexane]-4-one chemical structure, C20H20N2OS, CAS 328070-56-0
2-Prop-2-ynylsulfanylspiro[1,6-dihydrobenzo[h]quinazoline-5,1'-cyclohexane]-4-one
CAS 328070-56-0C20H20N2OS