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Murcko scaffold

Ring system with 3 rings and 19 atoms

22 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 19
Chemicals: 22
With full pages: 4

Scaffold SMILES

O=C(C=Cc1ccccc1)Nc1cc2c(s1)CCC2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(C=Cc1ccccc1)Nc1cc2c(s1)CCC2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 22 of 22 chemicals

Ethyl 2-(cinnamoylamino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C19H19NO3S, CAS 300828-83-5

Ethyl 2-(cinnamoylamino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate

CAS 300828-83-5C₁₉H₁₉NO₃S

2-{[3-(4-Methoxyphenyl)acryloyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid chemical structure, C18H17NO4S, CAS 312584-61-5

2-{[3-(4-Methoxyphenyl)acryloyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid

CAS 312584-61-5C₁₈H₁₇NO₄S

N-(3-Cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)cinnamamide chemical structure, C17H14N2OS, CAS 325987-59-5

N-(3-Cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)cinnamamide

CAS 325987-59-5C₁₇H₁₄N₂OS

Isopropyl 2-[(3-{4-nitrophenyl}acryloyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C20H20N2O5S, CAS 444928-28-3

Isopropyl 2-[(3-{4-nitrophenyl}acryloyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate

CAS 444928-28-3C₂₀H₂₀N₂O₅S

Isopropyl 2-{[3-(4-fluorophenyl)acryloyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C20H20FNO3S, CAS 444935-98-2

Isopropyl 2-{[3-(4-fluorophenyl)acryloyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate

CAS 444935-98-2C₂₀H₂₀FNO₃S

(E)-Ethyl 2-(3-(4-methoxyphenyl)acrylamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C20H21NO4S, CAS 301305-75-9

(E)-Ethyl 2-(3-(4-methoxyphenyl)acrylamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate

CAS 301305-75-9C₂₀H₂₁NO₄S

Ethyl 2-[[3-(3,4-dimethoxyphenyl)-1-oxo-2-propen-1-yl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C21H23NO5S, CAS 301305-74-8

Ethyl 2-[[3-(3,4-dimethoxyphenyl)-1-oxo-2-propen-1-yl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate

CAS 301305-74-8C₂₁H₂₃NO₅S

Methyl 2-{[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C20H21NO5S, CAS 292058-30-1

Methyl 2-{[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate

CAS 292058-30-1C₂₀H₂₁NO₅S

Methyl 2-{[(2E)-3-(4-propoxyphenyl)prop-2-enoyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C21H23NO4S, CAS 433966-80-4

Methyl 2-{[(2E)-3-(4-propoxyphenyl)prop-2-enoyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate

CAS 433966-80-4C₂₁H₂₃NO₄S

(E)-Methyl 2-(3-(2-methoxyphenyl)acrylamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C19H19NO4S, CAS 651009-28-8

(E)-Methyl 2-(3-(2-methoxyphenyl)acrylamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate

CAS 651009-28-8C₁₉H₁₉NO₄S

Propyl 2-[[(E)-3-(4-nitrophenyl)prop-2-enoyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C20H20N2O5S, CAS 444924-83-8

Propyl 2-[[(E)-3-(4-nitrophenyl)prop-2-enoyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate

CAS 444924-83-8C₂₀H₂₀N₂O₅S

Methyl 2-{[(2E)-3-(4-methoxyphenyl)prop-2-enoyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C19H19NO4S, CAS 302803-13-0

Methyl 2-{[(2E)-3-(4-methoxyphenyl)prop-2-enoyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate

CAS 302803-13-0C₁₉H₁₉NO₄S

Ethyl 2-[3-(2,4-dimethoxyphenyl)prop-2-enoylamino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C21H23NO5S, CAS 6873-58-1

Ethyl 2-[3-(2,4-dimethoxyphenyl)prop-2-enoylamino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate

CAS 6873-58-1C₂₁H₂₃NO₅S

Ethyl 2-{[(2E)-3-(2,5-dimethoxyphenyl)-2-propenoyl]amino}-5,6-dihydro-4H-cyclopenta[B]thiophene-3-carboxylate chemical structure, C21H23NO5S, CAS 301229-65-2

Ethyl 2-{[(2E)-3-(2,5-dimethoxyphenyl)-2-propenoyl]amino}-5,6-dihydro-4H-cyclopenta[B]thiophene-3-carboxylate

CAS 301229-65-2C₂₁H₂₃NO₅S

Dimethyl 2-{[(2E)-3-phenylprop-2-enoyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate chemical structure, C20H19NO5S, CAS 302802-64-8

Dimethyl 2-{[(2E)-3-phenylprop-2-enoyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate

CAS 302802-64-8C₂₀H₁₉NO₅S

Dimethyl 2-{[(2E)-3-(3,4-dimethoxyphenyl)-2-propenoyl]amino}-5,6-dihydro-4H-cyclopenta[B]thiophene-3,4-dicarboxylate chemical structure, C22H23NO7S, CAS 302802-63-7

Dimethyl 2-{[(2E)-3-(3,4-dimethoxyphenyl)-2-propenoyl]amino}-5,6-dihydro-4H-cyclopenta[B]thiophene-3,4-dicarboxylate

CAS 302802-63-7C₂₂H₂₃NO₇S

Ethyl 2-({(2E)-3-[3-methoxy-4-(pentyloxy)phenyl]prop-2-enoyl}amino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C25H31NO5S, CAS 292056-79-2

Ethyl 2-({(2E)-3-[3-methoxy-4-(pentyloxy)phenyl]prop-2-enoyl}amino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate

CAS 292056-79-2C₂₅H₃₁NO₅S

(E)-Dimethyl 2-(3-(2,4-dichlorophenyl)acrylamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate chemical structure, C20H17Cl2NO5S, CAS 329223-85-0

(E)-Dimethyl 2-(3-(2,4-dichlorophenyl)acrylamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate

CAS 329223-85-0C₂₀H₁₇Cl₂NO₅S

Dimethyl 2-({(2E)-3-[4-(hexyloxy)-3-methoxyphenyl]prop-2-enoyl}amino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate chemical structure, C27H33NO7S, CAS 307507-63-7

Dimethyl 2-({(2E)-3-[4-(hexyloxy)-3-methoxyphenyl]prop-2-enoyl}amino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate

CAS 307507-63-7C₂₇H₃₃NO₇S

Dimethyl 2-{[(2E)-3-(4-ethoxyphenyl)prop-2-enoyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate chemical structure, C22H23NO6S, CAS 385387-03-1

Dimethyl 2-{[(2E)-3-(4-ethoxyphenyl)prop-2-enoyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate

CAS 385387-03-1C₂₂H₂₃NO₆S

2-Cinnamamido-N-methyl-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide chemical structure, C18H18N2O2S, CAS 1322239-13-3

2-Cinnamamido-N-methyl-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide

CAS 1322239-13-3C₁₈H₁₈N₂O₂S

(E)-2-(3-(2-Chlorophenyl)acrylamido)-N-methyl-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide chemical structure, C18H17ClN2O2S, CAS 1322240-56-1

(E)-2-(3-(2-Chlorophenyl)acrylamido)-N-methyl-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide

CAS 1322240-56-1C₁₈H₁₇ClN₂O₂S