Murcko scaffold
Ring system with 3 rings and 19 atoms
72 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 19
- Chemicals
- 72
- With full pages
- 13
Scaffold SMILES
O=C(COc1ccccc1)Nc1cc2c(s1)CCC2
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 72 chemicals
![Ethyl 2-[(phenoxyacetyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C18H19NO4S, CAS 300828-70-0](/s/IVOFTJITCQUPMI-UHFFFAOYSA-N.svg)
Ethyl 2-[(phenoxyacetyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 300828-70-0C18H19NO4S
![N-(3-Cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-2-(3,4-dimethylphenoxy)acetamide chemical structure, C18H18N2O2S, CAS 326920-74-5](/s/OWOAJQSVWWBCHY-UHFFFAOYSA-N.svg)
N-(3-Cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-2-(3,4-dimethylphenoxy)acetamide
CAS 326920-74-5C18H18N2O2S
![Methyl 2-[[2-(4-chloro-2-methylphenoxy)acetyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C18H18ClNO4S, CAS 6145-30-8](/s/COYDBMVJQTZGKL-UHFFFAOYSA-N.svg)
Methyl 2-[[2-(4-chloro-2-methylphenoxy)acetyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 6145-30-8C18H18ClNO4S
![Methyl 2-{[(2-isopropyl-5-methylphenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C21H25NO4S, CAS 302803-21-0](/s/WTUJCYZZHCEQPL-UHFFFAOYSA-N.svg)
Methyl 2-{[(2-isopropyl-5-methylphenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 302803-21-0C21H25NO4S
![Methyl 2-{[(2-methoxyphenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C18H19NO5S, CAS 302803-33-4](/s/LHXACYJZGUSYOT-UHFFFAOYSA-N.svg)
Methyl 2-{[(2-methoxyphenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 302803-33-4C18H19NO5S
![Methyl 2-{[(2-bromo-4-methylphenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C18H18BrNO4S, CAS 302803-34-5](/s/WFWCAQTYMMBUTI-UHFFFAOYSA-N.svg)
Methyl 2-{[(2-bromo-4-methylphenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 302803-34-5C18H18BrNO4S
![Methyl 2-{[(4-chloro-3-methylphenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C18H18ClNO4S, CAS 302803-24-3](/s/QITXDVUNXUWCMJ-UHFFFAOYSA-N.svg)
Methyl 2-{[(4-chloro-3-methylphenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 302803-24-3C18H18ClNO4S
![Methyl 2-{[(3,4-dimethylphenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C19H21NO4S, CAS 302803-27-6](/s/GVFLVMIQYBHIPM-UHFFFAOYSA-N.svg)
Methyl 2-{[(3,4-dimethylphenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 302803-27-6C19H21NO4S
![Methyl 2-{[(3-chlorophenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C17H16ClNO4S, CAS 302803-29-8](/s/AJXQICSLHHOTNK-UHFFFAOYSA-N.svg)
Methyl 2-{[(3-chlorophenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 302803-29-8C17H16ClNO4S
![Methyl 2-[2-(2-tert-butylphenoxy)acetamido]-4H,5H,6H-cyclopenta[B]thiophene-3-carboxylate chemical structure, C21H25NO4S, CAS 302803-31-2](/s/PFGXNLZTFOGNBM-UHFFFAOYSA-N.svg)
Methyl 2-[2-(2-tert-butylphenoxy)acetamido]-4H,5H,6H-cyclopenta[B]thiophene-3-carboxylate
CAS 302803-31-2C21H25NO4S
![Methyl 2-{[(4-methoxyphenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C18H19NO5S, CAS 302803-20-9](/s/DPCYOAPCAYFOMN-UHFFFAOYSA-N.svg)
Methyl 2-{[(4-methoxyphenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 302803-20-9C18H19NO5S
![Methyl 2-{[(4-chlorophenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C17H16ClNO4S, CAS 324072-78-8](/s/DDAYQIFHJQCORK-UHFFFAOYSA-N.svg)
Methyl 2-{[(4-chlorophenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 324072-78-8C17H16ClNO4S
![Ethyl 2-[2-(4-chlorophenoxy)acetamido]-4H,5H,6H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C18H18ClNO4S, CAS 300828-76-6](/s/FFWGGWISEVNJFT-UHFFFAOYSA-N.svg)
Ethyl 2-[2-(4-chlorophenoxy)acetamido]-4H,5H,6H-cyclopenta[b]thiophene-3-carboxylate
CAS 300828-76-6C18H18ClNO4S
![2-(2-o-Tolyloxy-acetylamino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic chemical structure, C19H21NO4S, CAS 300826-09-9](/s/VJBIDAXFIFLMJR-UHFFFAOYSA-N.svg)
2-(2-o-Tolyloxy-acetylamino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic
CAS 300826-09-9C19H21NO4S
![Ethyl 2-{[(2-methoxyphenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C19H21NO5S, CAS 302550-11-4](/s/KREQWRFAAGOYRQ-UHFFFAOYSA-N.svg)
Ethyl 2-{[(2-methoxyphenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 302550-11-4C19H21NO5S
![Ethyl 2-[[2-(2,4-dichlorophenoxy)acetyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C18H17Cl2NO4S, CAS 300828-77-7](/s/ZHFGEVORUXINFH-UHFFFAOYSA-N.svg)
Ethyl 2-[[2-(2,4-dichlorophenoxy)acetyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 300828-77-7C18H17Cl2NO4S
![Ethyl 2-{[(2-isopropylphenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C21H25NO4S, CAS 301681-95-8](/s/BTTKPDXPEYNEIO-UHFFFAOYSA-N.svg)
Ethyl 2-{[(2-isopropylphenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 301681-95-8C21H25NO4S
![Ethyl 2-{[(4-bromo-3-methylphenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C19H20BrNO4S, CAS 302553-24-8](/s/QBFFFKNVBXVXDA-UHFFFAOYSA-N.svg)
Ethyl 2-{[(4-bromo-3-methylphenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 302553-24-8C19H20BrNO4S
![Ethyl 2-{[(2-bromo-4-methylphenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C19H20BrNO4S, CAS 301693-47-0](/s/GKNWYRMNPKAHPE-UHFFFAOYSA-N.svg)
Ethyl 2-{[(2-bromo-4-methylphenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 301693-47-0C19H20BrNO4S
![Ethyl 2-{[(3-bromophenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C18H18BrNO4S, CAS 302805-49-8](/s/FPONUOCMGUYHAK-UHFFFAOYSA-N.svg)
Ethyl 2-{[(3-bromophenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 302805-49-8C18H18BrNO4S
![Ethyl 2-{[(2,5-dichlorophenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C18H17Cl2NO4S, CAS 301305-01-1](/s/UBRUNWBEOLVOBM-UHFFFAOYSA-N.svg)
Ethyl 2-{[(2,5-dichlorophenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 301305-01-1C18H17Cl2NO4S
![2-[2-(2-tert-Butyl-4-methylphenoxy)acetamido]-4H,5H,6H-cyclopenta[B]thiophene-3-carboxamide chemical structure, C21H26N2O3S, CAS 301307-51-7](/s/XVKBFHUBWNWAHY-UHFFFAOYSA-N.svg)
2-[2-(2-tert-Butyl-4-methylphenoxy)acetamido]-4H,5H,6H-cyclopenta[B]thiophene-3-carboxamide
CAS 301307-51-7C21H26N2O3S
![Methyl 2-{[(4-isopropyl-3-methylphenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C21H25NO4S, CAS 431883-23-7](/s/HSTXACMCYVXXBK-UHFFFAOYSA-N.svg)
Methyl 2-{[(4-isopropyl-3-methylphenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 431883-23-7C21H25NO4S
![2-{[(2-Chlorophenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide chemical structure, C16H15ClN2O3S, CAS 301678-83-1](/s/LMHPVMKQEAONLK-UHFFFAOYSA-N.svg)
2-{[(2-Chlorophenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide
CAS 301678-83-1C16H15ClN2O3S
- Propyl 2-{[(3-methylphenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate515828-79-2C20H23NO4S
- Methyl 2-{[(2-bromo-4-ethylphenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate590400-41-2C19H20BrNO4S
- 2-[[2-(2-Methoxyphenoxy)acetyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide447427-48-7C17H18N2O4S
- 2-[[2-(4-Chlorophenoxy)-2-methylpropanoyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide746645-01-2C18H19ClN2O3S
- Ethyl 2-[2-(4-fluorophenoxy)acetamido]-4H,5H,6H-cyclopenta[b]thiophene-3-carboxylate618077-09-1C18H18FNO4S
- Ethyl 2-{[(4-isopropylphenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate651018-62-1C21H25NO4S
- N-(3-Cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-2-(4-methoxyphenoxy)acetamide461412-82-8C17H16N2O3S
- N-(3-Cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-2-phenoxyacetamide313469-66-8C16H14N2O2S
- Dimethyl 2-{[(4-chlorophenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate302802-71-7C19H18ClNO6S
- Dimethyl 2-{[(4-bromophenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate302802-72-8C19H18BrNO6S
- Dimethyl 2-{[(4-methoxyphenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate302802-73-9C20H21NO7S
- Dimethyl 2-[[2-(5-methyl-2-propan-2-ylphenoxy)acetyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate370845-44-6C23H27NO6S
- Dimethyl 2-{[(2,4-dibromophenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate302802-75-1C19H17Br2NO6S
- Dimethyl 2-{[(2,5-dimethylphenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate369393-44-2C21H23NO6S
- Dimethyl 2-{[(2-bromophenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate307537-50-4C19H18BrNO6S
- Dimethyl 2-{[(4-chloro-3,5-dimethylphenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate383892-01-1C21H22ClNO6S
- Dimethyl 2-[[2-(3,4-dimethylphenoxy)acetyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate370848-01-4C21H23NO6S
- Dimethyl 2-[(phenoxyacetyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate302802-69-3C19H19NO6S
- Dimethyl 2-{[(3-methylphenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate302802-70-6C20H21NO6S
- Dimethyl 2-[[2-(2,4-dichlorophenoxy)acetyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate302802-74-0C19H17Cl2NO6S
- Dimethyl 2-{[(4-chloro-3-methylphenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate302802-77-3C20H20ClNO6S
- Dimethyl 2-[[2-(4-propan-2-ylphenoxy)acetyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate329223-86-1C22H25NO6S
- Dimethyl 2-{[(3,5-dimethylphenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate302802-79-5C21H23NO6S
- Dimethyl 2-{[(2-chlorophenoxy)acetyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3,4-dicarboxylate302802-80-8C19H18ClNO6S
Related scaffolds
Same ring framework with different atoms or bond orders
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O=C(NCCc1ccccc1)C1=CN2CCN=C2S11 chemical![Scaffold O=C(NCCc1ccccc1)c1cc2sccc2[nH]1](/scaffold/XLJBULPHOPRTAW-UHFFFAOYSA-N/structure.svg)
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