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Murcko scaffold

Ring system with 3 rings and 20 atoms

14 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
14
With full pages
3
Scaffold SMILES

O=C(NC(=S)Nc1cc2c(s1)CCC2)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NC(=S)Nc1cc2c(s1)CCC2)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 14 of 14 chemicals

N-[(3-Cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)carbamothioyl]benzamide chemical structure, C16H13N3OS2, CAS 328072-42-0
N-[(3-Cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)carbamothioyl]benzamide
CAS 328072-42-0C16H13N3OS2
2-{[(Benzoylamino)carbothioyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid chemical structure, C16H14N2O3S2, CAS 351161-35-8
2-{[(Benzoylamino)carbothioyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid
CAS 351161-35-8C16H14N2O3S2
Ethyl 2-{[(benzoylamino)carbothioyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C18H18N2O3S2, CAS 55056-27-4
Ethyl 2-{[(benzoylamino)carbothioyl]amino}-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 55056-27-4C18H18N2O3S2
Ethyl 2-({[(4-methylphenyl)carbonyl]carbamothioyl}amino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C19H20N2O3S2, CAS 290835-60-8
Ethyl 2-({[(4-methylphenyl)carbonyl]carbamothioyl}amino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 290835-60-8C19H20N2O3S2
2-[(3,5-Dimethylbenzoyl)carbamothioylamino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide chemical structure, C18H19N3O2S2, CAS 677295-09-9
2-[(3,5-Dimethylbenzoyl)carbamothioylamino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide
CAS 677295-09-9C18H19N3O2S2
Ethyl 2-(3-(2-bromobenzoyl)thioureido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C18H17BrN2O3S2, CAS 312946-28-4
Ethyl 2-(3-(2-bromobenzoyl)thioureido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 312946-28-4C18H17BrN2O3S2
Ethyl 2-({[(3-methylphenyl)carbonyl]carbamothioyl}amino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C19H20N2O3S2, CAS 5539-95-7
Ethyl 2-({[(3-methylphenyl)carbonyl]carbamothioyl}amino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 5539-95-7C19H20N2O3S2
2-[(5-Bromo-2-methoxybenzoyl)carbamothioylamino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide chemical structure, C17H16BrN3O3S2, CAS 591241-37-1
2-[(5-Bromo-2-methoxybenzoyl)carbamothioylamino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide
CAS 591241-37-1C17H16BrN3O3S2
2-[[[[(4-Methoxy-3-nitrophenyl)-oxomethyl]amino]-sulfanylidenemethyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid ethyl ester chemical structure, C19H19N3O6S2, CAS 433329-89-6
2-[[[[(4-Methoxy-3-nitrophenyl)-oxomethyl]amino]-sulfanylidenemethyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid ethyl ester
CAS 433329-89-6C19H19N3O6S2
2-[(2-Methoxy-3-methylbenzoyl)carbamothioylamino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide chemical structure, C18H19N3O3S2, CAS 591735-25-0
2-[(2-Methoxy-3-methylbenzoyl)carbamothioylamino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide
CAS 591735-25-0C18H19N3O3S2
Methyl 4-(((3-cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)carbamothioyl)carbamoyl)benzoate chemical structure, C18H15N3O3S2, CAS 477508-84-2
Methyl 4-(((3-cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)carbamothioyl)carbamoyl)benzoate
CAS 477508-84-2C18H15N3O3S2
Ano1-IN-2 chemical structure, C16H14ClN3O2S2, CAS 637314-12-6
Ano1-IN-2
CAS 637314-12-6C16H14ClN3O2S2
Ethyl 2-[(4-methoxycarbonylbenzoyl)carbamothioylamino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate chemical structure, C20H20N2O5S2, CAS 477508-79-5
Ethyl 2-[(4-methoxycarbonylbenzoyl)carbamothioylamino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
CAS 477508-79-5C20H20N2O5S2
4-(tert-Butyl)-N-((3-cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)carbamothioyl)benzamide chemical structure, C20H21N3OS2, CAS 477508-82-0
4-(tert-Butyl)-N-((3-cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)carbamothioyl)benzamide
CAS 477508-82-0C20H21N3OS2