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Murcko scaffold

Ring system with 4 rings and 28 atoms

18 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 28
Chemicals: 18
With full pages: 4

Scaffold SMILES

O=C(CSc1nnc(SCc2cccc3ccccc23)s1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(CSc1nnc(SCc2cccc3ccccc23)s1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 18 of 18 chemicals

N-(4-Methoxyphenyl)-2-({5-[(naphthalen-1-ylmethyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide chemical structure, C22H19N3O2S3, CAS 613228-23-2

N-(4-Methoxyphenyl)-2-({5-[(naphthalen-1-ylmethyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide

CAS 613228-23-2C₂₂H₁₉N₃O₂S₃

N-(2-Methoxy-5-methylphenyl)-2-({5-[(naphthalen-1-ylmethyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide chemical structure, C23H21N3O2S3, CAS 613226-16-7

N-(2-Methoxy-5-methylphenyl)-2-({5-[(naphthalen-1-ylmethyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide

CAS 613226-16-7C₂₃H₂₁N₃O₂S₃

N-(4-Ethoxyphenyl)-2-({5-[(naphthalen-1-ylmethyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide chemical structure, C23H21N3O2S3, CAS 613228-25-4

N-(4-Ethoxyphenyl)-2-({5-[(naphthalen-1-ylmethyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide

CAS 613228-25-4C₂₃H₂₁N₃O₂S₃

N-(3-Chloro-4-methoxyphenyl)-2-({5-[(naphthalen-1-ylmethyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide chemical structure, C22H18ClN3O2S3, CAS 613228-26-5

N-(3-Chloro-4-methoxyphenyl)-2-({5-[(naphthalen-1-ylmethyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide

CAS 613228-26-5C₂₂H₁₈ClN₃O₂S₃

N-(2-Fluorophenyl)-2-({5-[(naphthalen-1-ylmethyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide chemical structure, C21H16FN3OS3, CAS 498546-37-5

N-(2-Fluorophenyl)-2-({5-[(naphthalen-1-ylmethyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide

CAS 498546-37-5C₂₁H₁₆FN₃OS₃

N-(4-Fluorophenyl)-2-({5-[(naphthalen-1-ylmethyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide chemical structure, C21H16FN3OS3, CAS 498546-39-7

N-(4-Fluorophenyl)-2-({5-[(naphthalen-1-ylmethyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide

CAS 498546-39-7C₂₁H₁₆FN₃OS₃

2-[[5-(Naphthalen-1-ylmethylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(4-sulfamoylphenyl)acetamide chemical structure, C21H18N4O3S4, CAS 613251-69-7

2-[[5-(Naphthalen-1-ylmethylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(4-sulfamoylphenyl)acetamide

CAS 613251-69-7C₂₁H₁₈N₄O₃S₄

N-(3,4-Dimethoxyphenyl)-2-({5-[(naphthalen-1-ylmethyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide chemical structure, C23H21N3O3S3, CAS 613228-27-6

N-(3,4-Dimethoxyphenyl)-2-({5-[(naphthalen-1-ylmethyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide

CAS 613228-27-6C₂₃H₂₁N₃O₃S₃

N-(3,4-Difluorophenyl)-2-({5-[(naphthalen-1-ylmethyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide chemical structure, C21H15F2N3OS3, CAS 613226-21-4

N-(3,4-Difluorophenyl)-2-({5-[(naphthalen-1-ylmethyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide

CAS 613226-21-4C₂₁H₁₅F₂N₃OS₃

N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-({5-[(naphthalen-1-ylmethyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide chemical structure, C22H15ClF3N3OS3, CAS 613228-24-3

N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-({5-[(naphthalen-1-ylmethyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide

CAS 613228-24-3C₂₂H₁₅ClF₃N₃OS₃

N-(3-Chloro-4-methylphenyl)-2-[[5-(naphthalen-1-ylmethylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide chemical structure, C22H18ClN3OS3, CAS 613226-30-5

N-(3-Chloro-4-methylphenyl)-2-[[5-(naphthalen-1-ylmethylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide

CAS 613226-30-5C₂₂H₁₈ClN₃OS₃

N-Mesityl-2-((5-((1-naphthylmethyl)thio)-1,3,4-thiadiazol-2-yl)thio)acetamide chemical structure, C24H23N3OS3, CAS 618880-46-9

N-Mesityl-2-((5-((1-naphthylmethyl)thio)-1,3,4-thiadiazol-2-yl)thio)acetamide

CAS 618880-46-9C₂₄H₂₃N₃OS₃

N-(4-Methylphenyl)-2-({5-[(naphthalen-1-ylmethyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide chemical structure, C22H19N3OS3, CAS 613228-28-7

N-(4-Methylphenyl)-2-({5-[(naphthalen-1-ylmethyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide

CAS 613228-28-7C₂₂H₁₉N₃OS₃

N-(2-Bromo-4,6-difluorophenyl)-2-((5-((1-naphthylmethyl)sulfanyl)-1,3,4-thiadiazol-2-yl)sulfanyl)acetamide chemical structure, C21H14BrF2N3OS3, CAS 476484-12-5

N-(2-Bromo-4,6-difluorophenyl)-2-((5-((1-naphthylmethyl)sulfanyl)-1,3,4-thiadiazol-2-yl)sulfanyl)acetamide

CAS 476484-12-5C₂₁H₁₄BrF₂N₃OS₃

N-(3,5-Dimethylphenyl)-2-({5-[(1-naphthylmethyl)sulfanyl]-1,3,4-thiadiazol-2-YL}sulfanyl)acetamide chemical structure, C23H21N3OS3, CAS 476484-09-0

N-(3,5-Dimethylphenyl)-2-({5-[(1-naphthylmethyl)sulfanyl]-1,3,4-thiadiazol-2-YL}sulfanyl)acetamide

CAS 476484-09-0C₂₃H₂₁N₃OS₃

N-(3-Fluorophenyl)-2-({5-[(naphthalen-1-ylmethyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide chemical structure, C21H16FN3OS3, CAS 613226-20-3

N-(3-Fluorophenyl)-2-({5-[(naphthalen-1-ylmethyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide

CAS 613226-20-3C₂₁H₁₆FN₃OS₃

Methyl 4-{[({5-[(1-naphthylmethyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetyl]amino}benzoate chemical structure, C23H19N3O3S3, CAS 613226-22-5

Methyl 4-{[({5-[(1-naphthylmethyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetyl]amino}benzoate

CAS 613226-22-5C₂₃H₁₉N₃O₃S₃

N-(2-Isopropylphenyl)-2-((5-((1-naphthylmethyl)sulfanyl)-1,3,4-thiadiazol-2-yl)sulfanyl)acetamide chemical structure, C24H23N3OS3, CAS 618880-45-8

N-(2-Isopropylphenyl)-2-((5-((1-naphthylmethyl)sulfanyl)-1,3,4-thiadiazol-2-yl)sulfanyl)acetamide

CAS 618880-45-8C₂₄H₂₃N₃OS₃