Murcko scaffold
Thieno(3,2-d)pyrimidine-2,4(1H,3H)-dione scaffold
49 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 11
- Chemicals
- 49
- With full pages
- 5
Scaffold SMILES
O=c1[nH]c(=O)c2sccc2[nH]1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
![Murcko scaffold O=c1[nH]c(=O)c2sccc2[nH]1](/scaffold/QAFVXBQPQCSSLI-UHFFFAOYSA-N/structure.svg)
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 49 chemicals
![3-Hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione chemical structure, C6H4N2O3S, CAS 53229-51-9](/s/PPUWOFYPBMFNQL-UHFFFAOYSA-N.svg)
3-Hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione
CAS 53229-51-9C6H4N2O3S
![3-(2-Hydroxyethyl)thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione chemical structure, C8H8N2O3S, CAS 123495-12-5](/s/OYYCHJJSVIVXSZ-UHFFFAOYSA-N.svg)
3-(2-Hydroxyethyl)thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione
CAS 123495-12-5C8H8N2O3S
![N-[(2,4-Dioxo-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl)acetyl]glycine chemical structure, C10H9N3O5S, CAS 852454-09-2](/s/FCUYADRZXDQXJD-UHFFFAOYSA-N.svg)
N-[(2,4-Dioxo-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl)acetyl]glycine
CAS 852454-09-2C10H9N3O5S
![6-(2,4-Dioxo-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl)hexanoic acid chemical structure, C12H14N2O4S, CAS 702664-44-6](/s/XGJNVIJEZVZTFV-UHFFFAOYSA-N.svg)
6-(2,4-Dioxo-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl)hexanoic acid
CAS 702664-44-6C12H14N2O4S
![3-(2,4-Dioxo-1H-thieno[3,2-d]pyrimidin-3-yl)-N-(2-ethylhexyl)propanamide chemical structure, C17H25N3O3S, CAS 686735-29-5](/s/GTHHDQWYIBOBAK-UHFFFAOYSA-N.svg)
3-(2,4-Dioxo-1H-thieno[3,2-d]pyrimidin-3-yl)-N-(2-ethylhexyl)propanamide
CAS 686735-29-5C17H25N3O3S
![4-(2,4-Dioxo-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl)butanoic acid chemical structure, C10H10N2O4S, CAS 702664-43-5](/s/WKIQTWKLNMZWBQ-UHFFFAOYSA-N.svg)
4-(2,4-Dioxo-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl)butanoic acid
CAS 702664-43-5C10H10N2O4S
Thieno(3,2-d)pyrimidine-2,4(1H,3H)-dione
CAS 16233-51-5C6H4N2O2S
![7-Methylthieno[3,2-d]pyrimidine-2,4(1H,3H)-dione chemical structure, C7H6N2O2S, CAS 35265-81-7](/s/XFXGDEBYBPGDLF-UHFFFAOYSA-N.svg)
7-Methylthieno[3,2-d]pyrimidine-2,4(1H,3H)-dione
CAS 35265-81-7C7H6N2O2S
![1-(2,4-Dioxo-1,2,3,4-tetrahydrothieno[3,2-d]pyrimidin-7-yl)guanidine chemical structure, C7H7N5O2S, CAS 538360-42-8](/s/DKIJGXHVUUUHOS-UHFFFAOYSA-N.svg)
1-(2,4-Dioxo-1,2,3,4-tetrahydrothieno[3,2-d]pyrimidin-7-yl)guanidine
CAS 538360-42-8C7H7N5O2S
![3-Methylthieno[3,2-d]pyrimidine-2,4(1H,3H)-dione chemical structure, C7H6N2O2S, CAS 123260-26-4](/s/LKBXFZMPEOSZQK-UHFFFAOYSA-N.svg)
3-Methylthieno[3,2-d]pyrimidine-2,4(1H,3H)-dione
CAS 123260-26-4C7H6N2O2S
![5-(2,4-Dioxo-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl)-N-(3-methylbutyl)pentanamide chemical structure, C16H23N3O3S, CAS 892267-04-8](/s/GKWKJYJKOUPECR-UHFFFAOYSA-N.svg)
5-(2,4-Dioxo-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl)-N-(3-methylbutyl)pentanamide
CAS 892267-04-8C16H23N3O3S
![7-Bromothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione chemical structure, C6H3BrN2O2S, CAS 41102-02-7](/s/XTTGKZVCJRAADD-UHFFFAOYSA-N.svg)
7-Bromothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione
CAS 41102-02-7C6H3BrN2O2S
![4-(2,4-Dioxo-1,2-dihydrothieno[3,2-d]pyrimidin-3(4H)-yl)-N-(3-ethoxypropyl)butanamide chemical structure, C15H21N3O4S, CAS 892266-88-5](/s/KJLSVSSAYYCSBO-UHFFFAOYSA-N.svg)
4-(2,4-Dioxo-1,2-dihydrothieno[3,2-d]pyrimidin-3(4H)-yl)-N-(3-ethoxypropyl)butanamide
CAS 892266-88-5C15H21N3O4S
![N-(3-Methylbutyl)-2-[3-(3-methylbutyl)-2,4-dioxo-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl]acetamide chemical structure, C18H27N3O3S, CAS 1252821-97-8](/s/SEEMYCYXJPMJFP-UHFFFAOYSA-N.svg)
N-(3-Methylbutyl)-2-[3-(3-methylbutyl)-2,4-dioxo-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl]acetamide
CAS 1252821-97-8C18H27N3O3S
![2-(3-Butyl-2,4-dioxo-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl)-N,N-diethylacetamide chemical structure, C16H23N3O3S, CAS 1252862-26-2](/s/YABMSPQCNNJUEK-UHFFFAOYSA-N.svg)
2-(3-Butyl-2,4-dioxo-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl)-N,N-diethylacetamide
CAS 1252862-26-2C16H23N3O3S
![2-(3-Butyl-2,4-dioxo-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl)-N-(2-methoxyethyl)acetamide chemical structure, C15H21N3O4S, CAS 1252843-68-7](/s/GZGHLNOBBZGJMB-UHFFFAOYSA-N.svg)
2-(3-Butyl-2,4-dioxo-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl)-N-(2-methoxyethyl)acetamide
CAS 1252843-68-7C15H21N3O4S
![2-(3-Butyl-2,4-dioxo-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl)-N-(3-methoxypropyl)acetamide chemical structure, C16H23N3O4S, CAS 1252928-89-4](/s/MXWGPTFWTNKXLT-UHFFFAOYSA-N.svg)
2-(3-Butyl-2,4-dioxo-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl)-N-(3-methoxypropyl)acetamide
CAS 1252928-89-4C16H23N3O4S
![2-(3-Butyl-2,4-dioxo-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl)-N,N-dipropylacetamide chemical structure, C18H27N3O3S, CAS 1252922-86-3](/s/SDEKJEGBXXESRM-UHFFFAOYSA-N.svg)
2-(3-Butyl-2,4-dioxo-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl)-N,N-dipropylacetamide
CAS 1252922-86-3C18H27N3O3S
![N,N-Diethyl-2-[3-(2-methylpropyl)-2,4-dioxo-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl]acetamide chemical structure, C16H23N3O3S, CAS 1260938-39-3](/s/CEZZOLKLGLOZKW-UHFFFAOYSA-N.svg)
N,N-Diethyl-2-[3-(2-methylpropyl)-2,4-dioxo-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl]acetamide
CAS 1260938-39-3C16H23N3O3S
![N-Butyl-2-[3-(2-methylpropyl)-2,4-dioxo-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl]acetamide chemical structure, C16H23N3O3S, CAS 1260929-57-4](/s/QKEIYPAGYJVECH-UHFFFAOYSA-N.svg)
N-Butyl-2-[3-(2-methylpropyl)-2,4-dioxo-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl]acetamide
CAS 1260929-57-4C16H23N3O3S
![N-(Butan-2-yl)-2-[3-(2-methylpropyl)-2,4-dioxo-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl]acetamide chemical structure, C16H23N3O3S, CAS 1260939-26-1](/s/AXZQHZBYJLKICG-UHFFFAOYSA-N.svg)
N-(Butan-2-yl)-2-[3-(2-methylpropyl)-2,4-dioxo-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl]acetamide
CAS 1260939-26-1C16H23N3O3S
![N-(3-Methylbutyl)-2-[3-(2-methylpropyl)-2,4-dioxo-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl]acetamide chemical structure, C17H25N3O3S, CAS 1260938-78-0](/s/ZUOAVUNYQIVURU-UHFFFAOYSA-N.svg)
N-(3-Methylbutyl)-2-[3-(2-methylpropyl)-2,4-dioxo-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl]acetamide
CAS 1260938-78-0C17H25N3O3S
![N-Butyl-N-ethyl-2-[3-(2-methylpropyl)-2,4-dioxo-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl]acetamide chemical structure, C18H27N3O3S, CAS 1261007-40-2](/s/QPROSFPMOJBJFZ-UHFFFAOYSA-N.svg)
N-Butyl-N-ethyl-2-[3-(2-methylpropyl)-2,4-dioxo-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl]acetamide
CAS 1261007-40-2C18H27N3O3S
![3-Ethylthieno[3,2-d]pyrimidine-2,4(1H,3H)-dione chemical structure, C8H8N2O2S, CAS 1239758-47-4](/s/HUEBFGBGMMUSMO-UHFFFAOYSA-N.svg)
3-Ethylthieno[3,2-d]pyrimidine-2,4(1H,3H)-dione
CAS 1239758-47-4C8H8N2O2S
- 3-Propylthieno[3,2-d]pyrimidine-2,4(1H,3H)-dione1239840-11-9C9H10N2O2S
- 3-Isopropylthieno[3,2-d]pyrimidine-2,4(1H,3H)-dione1239743-72-6C9H10N2O2S
- 6-Methylthieno[3,2-d]pyrimidine-2,4(1H,3H)-dione35265-80-6C7H6N2O2S
- 3-Isopentylthieno[3,2-d]pyrimidine-2,4(1H,3H)-dione1239779-71-5C11H14N2O2S
- 3-(3-Isopropoxypropyl)thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione1239757-13-1C12H16N2O3S
- 6-Nitro-1H-thieno[3,2-d]pyrimidine-2,4-dione41102-05-0C6H3N3O4S
- 7-Nitrothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione41102-06-1C6H3N3O4S
- 3-Allyloxy-1H-thieno[3,2-d]pyrimidine-2,4-dione875570-35-7C9H8N2O3S
- 3-Aminothieno[3,2-D]pyrimidine-2,4(1H,3H)-dione1132690-58-4C6H5N3O2S
- 7-Iodothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione1033744-29-4C6H3IN2O2S
- 3-(2-Aminoethyl)thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione1934800-66-4C8H9N3O2S
- Ethyl 3-(3-(2-(2,4-dioxo-1,2-dihydrothieno[3,2-d]pyrimidin-3(4H)-yl)ethyl)ureido)propanoate2034285-77-1C14H18N4O5S
- tert-Butyl (1-((2-(2,4-dioxo-1,2-dihydrothieno[3,2-d]pyrimidin-3(4H)-yl)ethyl)amino)-1-oxopropan-2-yl)carbamate1902922-44-4C16H22N4O5S
- 2-(3-Allyl-2,4-dioxo-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl)acetic acid1239736-20-9C11H10N2O4S
- 3-(1-Methyl-2,4-dioxo-1,2-dihydrothieno[3,2-d]pyrimidin-3(4H)-yl)propanoic acid1708079-98-4C10H10N2O4S
- 6-Fluorothieno[3,2-d]pyrimidine-2,4-diol1442082-86-1C6H3FN2O2S
- 6,7-Dibromothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione1442083-50-2C6H2Br2N2O2S
- tert-Butyl (2-(2,4-dioxo-1,2-dihydrothieno[3,2-d]pyrimidin-3(4H)-yl)ethyl)carbamate2034469-47-9C13H17N3O4S
- 6-Bromothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione1388027-23-3C6H3BrN2O2S
- 1-Ethyl-3-propylthieno[3,2-d]pyrimidine-2,4(1H,3H)-dione2309311-03-1C11H14N2O2S
- 6-(Trifluoromethyl)thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione2292197-92-1C7H3F3N2O2S
- 1-But-2-ynyl-3-prop-2-enylthieno[3,2-d]pyrimidine-2,4-dione2309557-96-6C13H12N2O2S
- 6-Chloro-1H,2H,3H,4H-thieno(3,2-d)pyrimidine-2,4-dione41102-03-8C6H3ClN2O2S
- 3-Butyl-1-ethyl-1H,2H,3H,4H-thieno[3,2-d]pyrimidine-2,4-dione2742051-82-5C12H16N2O2S
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