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Murcko scaffold

Ring system with 4 rings and 18 atoms

34 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 18
Chemicals: 34
With full pages: 6

Scaffold SMILES

O=C1Nc2ccccc2C12C=COc1n[nH]cc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1Nc2ccccc2C12C=COc1n[nH]cc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 34 of 34 chemicals

6-Amino-3-isopropyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile-4-spiro-3'-(1'-ethyl-1',3'-dihydro-2'H-indol-2'-one) chemical structure, C19H19N5O2, CAS 674801-48-0

6-Amino-3-isopropyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile-4-spiro-3'-(1'-ethyl-1',3'-dihydro-2'H-indol-2'-one)

CAS 674801-48-0C₁₉H₁₉N₅O₂

6-Amino-3-(methoxymethyl)-1'-methyl-2'-oxospiro[2H-pyrano[2,3-c]pyrazole-4,3'-indole]-5-carbonitrile chemical structure, C17H15N5O3, CAS 674807-47-7

6-Amino-3-(methoxymethyl)-1'-methyl-2'-oxospiro[2H-pyrano[2,3-c]pyrazole-4,3'-indole]-5-carbonitrile

CAS 674807-47-7C₁₇H₁₅N₅O₃

6'-Amino-3'-butyl-1-ethyl-1,1',3,4'-tetrahydro-2-oxospiro(2H-indole-3,4'-pyrano[2,3-c]pyrazole)-5'-carbonitrile chemical structure, C20H21N5O2, CAS 674807-55-7

6'-Amino-3'-butyl-1-ethyl-1,1',3,4'-tetrahydro-2-oxospiro(2H-indole-3,4'-pyrano[2,3-c]pyrazole)-5'-carbonitrile

CAS 674807-55-7C₂₀H₂₁N₅O₂

6'-Amino-3'-methyl-2-oxo-1,2-dihydro-1'H-spiro[indole-3,4'-pyrano[2,3-c]pyrazole]-5'-carbonitrile chemical structure, C15H11N5O2, CAS 106536-38-3

6'-Amino-3'-methyl-2-oxo-1,2-dihydro-1'H-spiro[indole-3,4'-pyrano[2,3-c]pyrazole]-5'-carbonitrile

CAS 106536-38-3C₁₅H₁₁N₅O₂

6-Amino-5-cyano-5'-fluoro-3-methyl-1,1',3',4-tetrahydro-2'-oxospiro(pyrano[2,3-c]pyrazole-4,3'-[2'H]-indole) chemical structure, C15H10FN5O2, CAS 296769-48-7

6-Amino-5-cyano-5'-fluoro-3-methyl-1,1',3',4-tetrahydro-2'-oxospiro(pyrano[2,3-c]pyrazole-4,3'-[2'H]-indole)

CAS 296769-48-7C₁₅H₁₀FN₅O₂

6-Amino-1'-ethyl-3-(methoxymethyl)-2'-oxospiro[2H-pyrano[2,3-c]pyrazole-4,3'-indole]-5-carbonitrile chemical structure, C18H17N5O3, CAS 845984-34-1

6-Amino-1'-ethyl-3-(methoxymethyl)-2'-oxospiro[2H-pyrano[2,3-c]pyrazole-4,3'-indole]-5-carbonitrile

CAS 845984-34-1C₁₈H₁₇N₅O₃

6'-Amino-5-chloro-3'-ethyl-2-oxospiro[1H-indole-3,4'-2H-pyrano[2,3-c]pyrazole]-5'-carbonitrile chemical structure, C16H12ClN5O2, CAS 665000-55-5

6'-Amino-5-chloro-3'-ethyl-2-oxospiro[1H-indole-3,4'-2H-pyrano[2,3-c]pyrazole]-5'-carbonitrile

CAS 665000-55-5C₁₆H₁₂ClN₅O₂

6-Amino-5'-bromo-1',3-dimethyl-2'-oxospiro[2H-pyrano[2,3-c]pyrazole-4,3'-indole]-5-carbonitrile chemical structure, C16H12BrN5O2, CAS 848998-56-1

6-Amino-5'-bromo-1',3-dimethyl-2'-oxospiro[2H-pyrano[2,3-c]pyrazole-4,3'-indole]-5-carbonitrile

CAS 848998-56-1C₁₆H₁₂BrN₅O₂

6'-Amino-5-chloro-3'-methyl-2-oxospiro[1H-indole-3,4'-2H-pyrano[2,3-c]pyrazole]-5'-carbonitrile chemical structure, C15H10ClN5O2, CAS 296800-64-1

6'-Amino-5-chloro-3'-methyl-2-oxospiro[1H-indole-3,4'-2H-pyrano[2,3-c]pyrazole]-5'-carbonitrile

CAS 296800-64-1C₁₅H₁₀ClN₅O₂

6-Amino-1',3-diethyl-2'-oxospiro[2H-pyrano[2,3-c]pyrazole-4,3'-indole]-5-carbonitrile chemical structure, C18H17N5O2, CAS 674807-53-5

6-Amino-1',3-diethyl-2'-oxospiro[2H-pyrano[2,3-c]pyrazole-4,3'-indole]-5-carbonitrile

CAS 674807-53-5C₁₈H₁₇N₅O₂

6-Amino-3-ethyl-1'-methyl-2'-oxospiro[2H-pyrano[2,3-c]pyrazole-4,3'-indole]-5-carbonitrile chemical structure, C17H15N5O2, CAS 674807-45-5

6-Amino-3-ethyl-1'-methyl-2'-oxospiro[2H-pyrano[2,3-c]pyrazole-4,3'-indole]-5-carbonitrile

CAS 674807-45-5C₁₇H₁₅N₅O₂

6-Amino-5-cyano-3-ethyl-2'-oxo-1,1',3',4-tetrahydrospiro[pyrano[2,3-c]pyrazole-4,3'-(2'H)-indole] chemical structure, C16H13N5O2, CAS 309922-12-1

6-Amino-5-cyano-3-ethyl-2'-oxo-1,1',3',4-tetrahydrospiro[pyrano[2,3-c]pyrazole-4,3'-(2'H)-indole]

CAS 309922-12-1C₁₆H₁₃N₅O₂

6'-Amino-3'-(methoxymethyl)-1,1',3,4'-dihydro-2-oxospiro(2H-indole-3,4'-pyrano[2,3-c]pyrazole)-5'-carbonitrile chemical structure, C16H13N5O3, CAS 674807-29-5

6'-Amino-3'-(methoxymethyl)-1,1',3,4'-dihydro-2-oxospiro(2H-indole-3,4'-pyrano[2,3-c]pyrazole)-5'-carbonitrile

CAS 674807-29-5C₁₆H₁₃N₅O₃

6-Amino-3-(methoxymethyl)-2'-oxo-1'-prop-2-enylspiro[2H-pyrano[2,3-c]pyrazole-4,3'-indole]-5-carbonitrile chemical structure, C19H17N5O3, CAS 674807-61-5

6-Amino-3-(methoxymethyl)-2'-oxo-1'-prop-2-enylspiro[2H-pyrano[2,3-c]pyrazole-4,3'-indole]-5-carbonitrile

CAS 674807-61-5C₁₉H₁₇N₅O₃

6-Amino-3-ethyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile-4-spiro-3'-(1'-allyl-1',3'-dihydro-2'H-indol-2'-one) chemical structure, C19H17N5O2, CAS 847035-00-1

6-Amino-3-ethyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile-4-spiro-3'-(1'-allyl-1',3'-dihydro-2'H-indol-2'-one)

CAS 847035-00-1C₁₉H₁₇N₅O₂

6'-Amino-3'-butyl-5-fluoro-2-oxospiro[1H-indole-3,4'-2H-pyrano[2,3-c]pyrazole]-5'-carbonitrile chemical structure, C18H16FN5O2, CAS 674807-59-1

6'-Amino-3'-butyl-5-fluoro-2-oxospiro[1H-indole-3,4'-2H-pyrano[2,3-c]pyrazole]-5'-carbonitrile

CAS 674807-59-1C₁₈H₁₆FN₅O₂

6-Amino-5'-chloro-5-cyano-2'-oxo-3-propyl-1,1',3',4-tetrahydrospiro[pyrano[2,3-c]pyrazole-4,3'-(2'H)-indol] chemical structure, C17H14ClN5O2, CAS 361367-96-6

6-Amino-5'-chloro-5-cyano-2'-oxo-3-propyl-1,1',3',4-tetrahydrospiro[pyrano[2,3-c]pyrazole-4,3'-(2'H)-indol]

CAS 361367-96-6C₁₇H₁₄ClN₅O₂

6-Amino-5'-chloro-5-cyano-3-isopropyl--2'-oxo-1,1',3',4-tetrahydrospiro[pyrano[2,3-c]pyrazole-4,3'-(2'H)-indole] chemical structure, C17H14ClN5O2, CAS 352329-94-3

6-Amino-5'-chloro-5-cyano-3-isopropyl--2'-oxo-1,1',3',4-tetrahydrospiro[pyrano[2,3-c]pyrazole-4,3'-(2'H)-indole]

CAS 352329-94-3C₁₇H₁₄ClN₅O₂

6-Amino-3-(tert-butyl)-11-oxospiro[4H-pyrano[2,3-c]pyrazole-4,3'-indoline]-5-c arbonitrile chemical structure, C18H17N5O2, CAS 300837-93-8

6-Amino-3-(tert-butyl)-11-oxospiro[4H-pyrano[2,3-c]pyrazole-4,3'-indoline]-5-c arbonitrile

CAS 300837-93-8C₁₈H₁₇N₅O₂

6'-Amino-3'-butyl-5-chloro-2-oxospiro[1H-indole-3,4'-2H-pyrano[2,3-c]pyrazole]-5'-carbonitrile chemical structure, C18H16ClN5O2, CAS 674807-36-4

6'-Amino-3'-butyl-5-chloro-2-oxospiro[1H-indole-3,4'-2H-pyrano[2,3-c]pyrazole]-5'-carbonitrile

CAS 674807-36-4C₁₈H₁₆ClN₅O₂

6-Amino-5-cyano-3-isopropyl-1,4-dihydro-2'-oxospiro(pyrano[2,3-c]pyrazole-4,3'-indoline) chemical structure, C17H15N5O2, CAS 352025-19-5

6-Amino-5-cyano-3-isopropyl-1,4-dihydro-2'-oxospiro(pyrano[2,3-c]pyrazole-4,3'-indoline)

CAS 352025-19-5C₁₇H₁₅N₅O₂

Ethyl 6-amino-3-methyl-2'-oxo-1'-prop-2-enylspiro[2H-pyrano[2,3-c]pyrazole-4,3'-indole]-5-carboxylate chemical structure, C20H20N4O4, CAS 445223-07-4

Ethyl 6-amino-3-methyl-2'-oxo-1'-prop-2-enylspiro[2H-pyrano[2,3-c]pyrazole-4,3'-indole]-5-carboxylate

CAS 445223-07-4C₂₀H₂₀N₄O₄

6'-Amino-3'-butyl-1,1',3,4'-tetrahydro-2-oxospiro(2H-indole-3,4'-pyrano[2,3-c]pyrazole)-5'-carbonitrile chemical structure, C18H17N5O2, CAS 674807-32-0

6'-Amino-3'-butyl-1,1',3,4'-tetrahydro-2-oxospiro(2H-indole-3,4'-pyrano[2,3-c]pyrazole)-5'-carbonitrile

CAS 674807-32-0C₁₈H₁₇N₅O₂

1'-Allyl-6-amino-5-cyano-3-methyl-2'-oxo-1,1',3',4-tetrahydrospiro(pyrano[2,3-c]pyrazole-4,3'-[2'H]-indole) chemical structure, C18H15N5O2, CAS 445222-49-1

1'-Allyl-6-amino-5-cyano-3-methyl-2'-oxo-1,1',3',4-tetrahydrospiro(pyrano[2,3-c]pyrazole-4,3'-[2'H]-indole)

CAS 445222-49-1C₁₈H₁₅N₅O₂