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Murcko scaffold

2-(1,3-Dioxo-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindol-2(3H)-yl)-N-phenylacetamide scaffold

17 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
17
With full pages
6
Scaffold SMILES

O=C(CN1C(=O)C2C3C=CC(C3)C2C1=O)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-(1,3-Dioxo-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindol-2(3H)-yl)-N-phenylacetamide page
Murcko scaffold O=C(CN1C(=O)C2C3C=CC(C3)C2C1=O)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 17 of 17 chemicals

N-(4-Bromo-3-chloro-2-methylphenyl)-2-(1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)acetamide chemical structure, C18H16BrClN2O3, CAS 1005053-27-9
N-(4-Bromo-3-chloro-2-methylphenyl)-2-(1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)acetamide
CAS 1005053-27-9C18H16BrClN2O3
2-(1,3-Dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)-N-(4-iodophenyl)acetamide chemical structure, C17H15IN2O3, CAS 489401-73-2
2-(1,3-Dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)-N-(4-iodophenyl)acetamide
CAS 489401-73-2C17H15IN2O3
N-(3,4-Dimethylphenyl)-2-(1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)acetamide chemical structure, C19H20N2O3, CAS 1005117-25-8
N-(3,4-Dimethylphenyl)-2-(1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)acetamide
CAS 1005117-25-8C19H20N2O3
N-(3-Chlorophenyl)-2-(1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)acetamide chemical structure, C17H15ClN2O3, CAS 444337-31-9
N-(3-Chlorophenyl)-2-(1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)acetamide
CAS 444337-31-9C17H15ClN2O3
Methyl 2-{[(1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)acetyl]amino}benzoate chemical structure, C19H18N2O5, CAS 444338-54-9
Methyl 2-{[(1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)acetyl]amino}benzoate
CAS 444338-54-9C19H18N2O5
N-(4-Bromophenyl)-2-(1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)acetamide chemical structure, C17H15BrN2O3, CAS 444337-41-1
N-(4-Bromophenyl)-2-(1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)acetamide
CAS 444337-41-1C17H15BrN2O3
N-(5-Chloro-2-methylphenyl)-2-(1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)acetamide chemical structure, C18H17ClN2O3, CAS 1005262-70-3
N-(5-Chloro-2-methylphenyl)-2-(1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)acetamide
CAS 1005262-70-3C18H17ClN2O3
2-(1,3-Dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)-N-(4-nitrophenyl)acetamide chemical structure, C17H15N3O5, CAS 1005262-85-0
2-(1,3-Dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)-N-(4-nitrophenyl)acetamide
CAS 1005262-85-0C17H15N3O5
2-(1,3-Dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)-N-(4-fluorophenyl)acetamide chemical structure, C17H15FN2O3, CAS 444338-46-9
2-(1,3-Dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)-N-(4-fluorophenyl)acetamide
CAS 444338-46-9C17H15FN2O3
N-(2,5-Dimethylphenyl)-2-(1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)propanamide chemical structure, C20H22N2O3, CAS 1094539-57-7
N-(2,5-Dimethylphenyl)-2-(1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)propanamide
CAS 1094539-57-7C20H22N2O3
Ethyl 4-{[2-(1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)propanoyl]amino}benzoate chemical structure, C21H22N2O5, CAS 1094539-51-1
Ethyl 4-{[2-(1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)propanoyl]amino}benzoate
CAS 1094539-51-1C21H22N2O5
2-(1,3-Dioxo-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindol-2(3H)-yl)-4-methyl-N-phenylpentanamide chemical structure, C21H24N2O3, CAS 1094605-30-7
2-(1,3-Dioxo-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindol-2(3H)-yl)-4-methyl-N-phenylpentanamide
CAS 1094605-30-7C21H24N2O3
Ethyl 4-(2-(1,3-dioxo-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindol-2(3H)-yl)-4-methylpentanamido)benzoate chemical structure, C24H28N2O5, CAS 1094605-32-9
Ethyl 4-(2-(1,3-dioxo-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindol-2(3H)-yl)-4-methylpentanamido)benzoate
CAS 1094605-32-9C24H28N2O5
N-(4-Bromo-2-chlorophenyl)-2-(1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)propanamide chemical structure, C18H16BrClN2O3, CAS 1093638-68-6
N-(4-Bromo-2-chlorophenyl)-2-(1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)propanamide
CAS 1093638-68-6C18H16BrClN2O3
2-(1,3-Dioxo-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindol-2(3H)-yl)-N-phenylacetamide chemical structure, C17H16N2O3, CAS 1005045-02-2
2-(1,3-Dioxo-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindol-2(3H)-yl)-N-phenylacetamide
CAS 1005045-02-2C17H16N2O3
2-((3aR,7aS)-1,3-Dioxo-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindol-2(3H)-yl)-N-(4-sulfamoylphenyl)propanamide chemical structure, C18H19N3O5S, CAS 1042743-61-2
2-((3aR,7aS)-1,3-Dioxo-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindol-2(3H)-yl)-N-(4-sulfamoylphenyl)propanamide
CAS 1042743-61-2C18H19N3O5S
2-((3aR,7aS)-1,3-Dioxo-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindol-2(3H)-yl)-3-methyl-N-(4-sulfamoylphenyl)butanamide chemical structure, C20H23N3O5S, CAS 1093390-59-0
2-((3aR,7aS)-1,3-Dioxo-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindol-2(3H)-yl)-3-methyl-N-(4-sulfamoylphenyl)butanamide
CAS 1093390-59-0C20H23N3O5S